全文获取类型
收费全文 | 671篇 |
免费 | 36篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 42篇 |
妇产科学 | 45篇 |
基础医学 | 51篇 |
口腔科学 | 8篇 |
临床医学 | 50篇 |
内科学 | 157篇 |
皮肤病学 | 9篇 |
神经病学 | 26篇 |
特种医学 | 22篇 |
外科学 | 61篇 |
综合类 | 15篇 |
预防医学 | 38篇 |
眼科学 | 9篇 |
药学 | 94篇 |
中国医学 | 2篇 |
肿瘤学 | 77篇 |
出版年
2023年 | 8篇 |
2022年 | 9篇 |
2021年 | 26篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 22篇 |
2017年 | 17篇 |
2016年 | 14篇 |
2015年 | 9篇 |
2014年 | 19篇 |
2013年 | 39篇 |
2012年 | 38篇 |
2011年 | 30篇 |
2010年 | 26篇 |
2009年 | 18篇 |
2008年 | 32篇 |
2007年 | 41篇 |
2006年 | 23篇 |
2005年 | 16篇 |
2004年 | 32篇 |
2003年 | 28篇 |
2002年 | 22篇 |
2001年 | 6篇 |
2000年 | 13篇 |
1999年 | 14篇 |
1998年 | 14篇 |
1997年 | 9篇 |
1995年 | 4篇 |
1993年 | 10篇 |
1992年 | 4篇 |
1991年 | 8篇 |
1990年 | 8篇 |
1989年 | 13篇 |
1988年 | 10篇 |
1987年 | 12篇 |
1986年 | 14篇 |
1985年 | 12篇 |
1984年 | 10篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 9篇 |
1972年 | 4篇 |
1971年 | 5篇 |
1970年 | 5篇 |
排序方式: 共有708条查询结果,搜索用时 0 毫秒
1.
2.
3.
The modulation of drug metabolising enzymes by Masheri extract (ME) and Benzo(a)Pyrene [B(a)P] was studied in male Sprague Dawley rats fed different dietary protein levels. Two groups of 21 days old male Sprague Dawley rats were put on a high protein diet (SHP) with 20% Casein, and a low protein diet (SLP) with 3% Casein semisynthetic based diets for 12 weeks. The SLP fed animals showed lower basal levels of the Phase I activating enzymes viz. Cytochrome P450, Benzo(a)Pyrene hydroxylase, Benzphetamine demethylase and Phase II glutathione detoxification system viz. Glutathione (GSH) and Glutathione-S-transferase. ME and B(a)P treatment significantly depleted the glutathione detoxification system in the SLP group whereas an opposite effect was observed in the SHP group. Interstingly, ME and B(a)P treated rats in the SLP group showed a higher percent increase in the hepatic and pulmonary Phase I enzyme activities than those observed in the treated ME/B(a)P treated SHP rats. Furthermore, both ME and B(a)P significantly decreased the hepatic pool of vitamin A while a concomittant increase in that of vitamin C was observed. 相似文献
4.
5.
Kevin E. Fisher Lizmery S. Ferguson Amy M. Coffey Brian Y. Merritt Jonathan L. Curry Andrea N. Marcogliese Angela M. Major Kala Y. Kamdar Dolores H. Lopez-Terrada Choladda V. Curry 《Haematologica》2022,107(8):1880
Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are immunomodulatory molecules over-expressed in lymphomas and are promising immunotherapy targets for hematologic malignancies. However, studies of PD-1/PD-L1 overexpression and their clinical significance in aggressive pediatric non-Hodgkin lymphomas (NHL) are limited. We assessed PD-1/PD-L1 overexpression using immunohistochemistry in 68 aggressive pediatric NHL: ALK-positive anaplastic large cell lymphoma (ALK+ ALCL, n=8), Burkitt lymphoma (BL, n=27), and large B-cell lymphoma (LBCL) de novo LBCL, n=22 and diffuse LBCL arising as monomorphic post-transplant lymphoproliferative disorder [PTLD-DLBCL], n=11. In LBCL, correlations between PD-L1 overexpression and Epstein-Barr virus (EBV) status, cell of origin, stage, nodal status, overall survival (OS), and event-free survival (EFS) were examined. The genetic mechanisms of PD-L1 overexpression were investigated using targeted next-generation sequencing (NGS) and cytogenetic data. All ALK+ ALCL samples, 50.0% of de novo LBCL (11/22), 72.7% of PTLD-DLBCL (8/11), and no BL overexpressed PD-L1. Overexpressed PD-L1 correlated with EBV positivity (P=0.033) in LBCL and lower EFS in de novo LBCL (P=0.017). NGS of select LBCL revealed distinct somatic mutations and an ultra-hypermutated PTLD-DLBCL. Most cases with 9p24.1 copy gains overexpressed PD-L1 although some cases had no discernible genetic drivers of PD-L1 overexpression. Overexpressed PD-L1 is common in pediatric LBCL, associated with EBV positivity and 9p24.1 gains, and may have prognostic significance in de novo LBCL. Furthermore, diverse molecular mechanisms for PD-L1 overexpression in aggressive pediatric NHL can occur. Thus, additional studies exploring the therapeutic and prognostic significance and molecular mechanisms of PD-L1 overexpression in aggressive pediatric NHL are warranted. 相似文献
6.
Brazdil Vojtech Kala Petr Hudec Martin Poloczek Martin Kanovsky Jan Stipal Roman Jerabek Petr Bocek Otakar Pail Martin Brazdil Milan 《Clinical autonomic research》2022,32(1):9-17
Clinical Autonomic Research - Takotsubo syndrome (TTS), also known as stress cardiomyopathy or “broken heart” syndrome, is a mysterious condition that often mimics an acute myocardial... 相似文献
7.
Nowadays, optical coherent tomography (OCT) as the most precise morphologic technique is used in the increasing number of cases, both in routine clinical situations and research projects. Huang and co-workers reported the first clinical use of the 2-dimensional OCT in 1991, suggesting the principle of its use both in ophthalmology and interventional cardiology. The method has developed rapidly since that time. Interventional cardiologists benefit from its detailed intravascular imaging ability, providing real-time information of the intracoronary pathology. Researchers acknowledge the resolution, allowing detailed analysis of vessel structure. Its axial resolution level is approximately 10–15 μm, which is far from any other method used in interventional cardiology. The review will address the principle of the method and the main fields of the relatively short history of the OCT use as a routine clinical imaging method. We will summarize the main OCT milestones in the research field and its possible future as well. The review will describe OCT as the method under rapid development that should be considered as a new “gold” or even “platinum” standard for the coronary vessels imaging. 相似文献
8.
9.
Petr Widimský Richard Rokyta Josef Št׳ásek Jan Bělohlávek Pavel Červinka Petr Kala 《Cor et vasa》2013,55(3):e225-e227
The Czech Society of Cardiology is proposing here the new classification of acute coronary syndromes at the time of the first medical contact. The proposal suggests to remove the terms “ST elevation myocardial infarction” and “non-ST elevation acute coronary syndrome” and to replace these terms by “acute coronary syndrome with ongoing myocardial ischemia” and “acute coronary syndrome without ongoing myocardial ischemia”. The proposed new classification better reflects current treatment approaches and will facilitate the decision making at the first medical contact. 相似文献
10.
Baqar Husaini Aashrai SV. Gudlavalleti Van Cain Robert Levine Majaz Moonis 《Indian Journal of Community Medicine》2015,40(4):258-263