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1.
Farooq Anwar Ali Abbas Tahir Mehmood Anwarul‐Hassan Gilani Najeeb‐ur Rehman 《Phytotherapy research : PTR》2019,33(10):2548-2570
The genus Mentha comprises several aromatic species, which are cultivated world‐over due to their distinct aroma and commercial value. In addition to traditional food flavoring uses, Mentha are well recognized for their folk medicinal uses, especially to treat cold, fever, and digestive and cardiovascular disorders. A number of biological activities such as antioxidant, antimicrobial, biopesticidal, antitumor, anticancer, antiviral, antiallergic, antiinflammatory, antihypertensive, and urease inhibitory activity have been ascribed to Mentha. The traditional pharmacological attributes of Mentha herbs can be linked to the occurrence of bioactive phytochemicals such as terpenoids, alcohols, rosmarinic acid, and antioxidant phenolics among others. A rich source of bioactives, different species of Mentha, can be explored as a promising candidate for the development of nutra‐pharmaceuticals. This review covers the nutritional, phytochemical, and traditional medicinal aspects and multiple biological activities of some commonly available species of Mentha so as to explore their potential applications for nutra‐pharmaceutical and cosmo‐nutraceutical industry. Detailed chemical profile and pharmaceutical attributes of various Mentha essential oils are also covered. Moreover, based on computational analysis, quantitative chemical component–antioxidant activity relationship model is reviewed to predict and correlate structure–activity relationship of potential bioactives in selected Mentha essential oils leading to discovery and developmenmt of novel natural drugs. 相似文献
2.
Boska MD Mosley RL Nawab M Nelson JA Zelivyanskaya M Poluektova L Uberti M Dou H Lewis TB Gendelman HE 《Current HIV research》2004,2(1):61-78
Persons with advanced human immunodeficiency virus type one (HIV-1) infection seek medical advice for a wide range of neurological disorders including, but not limited to, peripheral neuropathy, toxoplasmosis, cryptococcal meningitis, cytomegalovirus retinitis progressive multifocal leukoencephalopathy, lymphoma and dementia. The diagnosis of HIV-1-associated dementia (HAD) induced as a direct consequence of HIV infection of the brain comes commonly by exclusion. Diagnostic decisions can often be clouded by concomitant depression, motor impairments, and lethargy that follow debilitating immune suppression and weight loss. Indeed, cognitive, motor and behavior abnormalities underlie a variety of neurological dysfunctions associated with advanced HIV-1 infection. Thus, even combinations of clinical, laboratory and neuroimaging tests [for example, magnetic resonance imaging (MRI), computed tomography (CT), single photon emission computed tomography (SPECT) and positron emission tomography (PET)] often fail to provide conclusive diagnostic information. Nonetheless, the recent development of quantitative MR spectroscopic imaging has improved diagnostic possibilities for HAD. We are pleased to discuss these developments as well as taking a forward look into what will soon be made available to improve neuroimaging diagnostic precision. New MR and SPECT testing are being developed in our laboratories and elsewhere both for animal model systems and in humans with HIV-1 disease. Such tests can facilitate dynamic measures of HIV-1 neuropathogenesis providing information for disease events that even 2 years ago were unattainable. 相似文献
3.
Arshad Mehmood Muhammad Ishaq Lei Zhao Bushra Safdar Ashfaq‐ur Rehman Masooma Munir Ali Raza Muhammad Nadeem Waheed Iqbal Chengtao Wang 《Chemical biology & drug design》2019,93(4):387-418
Hyperuricemia (HUA), a disease due to an elevation of body uric acid level and responsible for various diseases such as gout, cardiovascular disorders, and renal failure, is a major ground debate for the medical science these days. Considering the risk factors linked with allopathic drugs for the treatment of this disease, the debate has now become a special issue. Previously, we critically discussed the role of dietary polyphenols in the treatment of HUA. Besides dietary food plants, many researchers figure out the tremendous effects of medicinal plants‐derived phytochemicals against HUA. Keeping in mind all these aspects, we reviewed all possible managerial studies related to HUA through medicinal plants (isolated compounds). In the current review article, we comprehensively discussed various bioactive compounds, chemical structures, and structure–activity relationship with responsible key enzyme xanthine oxidase. 相似文献
4.
Muddassir Mehmood Stephanie A. Ambach Michael D. Taylor John L. Jefferies Subha V. Raman Robin J. Taylor Hemant Sawani Jacob Mathew Wojciech Mazur Kan N. Hor Hussein R. Al-Khalidi 《Pediatric cardiology》2016,37(5):878-883
The relationship between pulmonary function and right ventricle (RV) in Duchenne muscular dystrophy (DMD) has not been evaluated. Using cardiac magnetic resonance (CMR), we describe the relationship of RV size and function with spirometry in a DMD cohort. Fifty-seven boys undergoing CMR and pulmonary function testing within 1 month at a single center (2013–2015) were enrolled. Comparisons of RV ejection fraction (RVEF) and end-diastolic volume index (RVEDVI) were made across categories of percent forced vital capacity (FVC%), and relationships were assessed. Mean age was 15.5 ± 3.5 years. Spirometry and CMR were performed within 3.9 ± 4.1 days. Median FVC% was 92.0 % (67.5–116.5 %). Twenty-three (40 %) patients had abnormal FVC% (<80 %) of which 13 (57 %) had mild (FVC% 60–79 %), 6 (26 %) had moderate (FVC% 40–59 %), and 4 (17 %) had severe (FVC <40 %) reductions. Mean RVEF was 58.3 ± 3.7 %. Patients with abnormal FVC% were older and had lower RVEF and RVEDVI. Both RVEF and RVEDVI were significantly associated with FVC% (r = 0.31, p = 0.02 and r = 0.39, p = 0.003, respectively). In a large DMD cohort, RVEF and RVEDVI were related to FVC%. Worsening respiratory status may guide monitoring of cardiac function in these patients. 相似文献
5.
Mansour Adam Mahmoud Yazeed Alswaida Thamir Alshammari Tahir Mehmood Khan Alian Alrasheedy Mohamad Azmi Hassali Hisham Aljadhey 《Saudi Pharmaceutical Journal》2014,22(5):411-418
Objective
To assess community pharmacists’ knowledge, behaviors and experiences relating to Adverse Drug Reaction (ADR) reporting in Saudi Arabia.Methods
A cross-sectional study was conducted using a validated self-administered questionnaire. A convenience sample of 147 community pharmacists working in community pharmacies in Riyadh, Saudi Arabia.Results
The questionnaire was distributed to 147 pharmacists, of whom 104 responded to the survey, a 70.7% response rate. The mean age of participants was 29 years. The majority (n = 101, 98.1%) had graduated with a bachelorette degree and worked in chain pharmacies (n = 68, 66.7%). Only 23 (22.1%) said they were familiar with the ADR reporting process, and only 21 (20.2%) knew that pharmacists can submit ADR reports online. The majority of the participants (n = 90, 86.5%) had never reported ADRs. Reasons for not reporting ADRs most importantly included lack of awareness about the method of reporting (n = 22, 45.9%), misconception that reporting ADRs is the duty of physician and hospital pharmacist (n = 8, 16.6%) and ADRs in community pharmacies are simple and should not be reported (n = 8, 16.6%). The most common approach perceived by community pharmacists for managing patients suffering from ADRs was to refer him/her to a physician (n = 80, 76.9%).Conclusion
The majority of community pharmacists in Riyadh have poor knowledge of the ADR reporting process. Pharmacovigilance authorities should take necessary steps to urgently design interventional programs in order to increase the knowledge and awareness of pharmacists regarding the ADR reporting process. 相似文献6.
Zhenyu Chang Hui Zhang Khalid Mehmood Min Luo Yali Zhao Fazul Nabi 《Toxin reviews》2019,38(2):115-120
We determine the effect of nano copper on visceral organs and contents of trace elements in organs and serum in weanling pigs. Our results showed that following supplementary concentration with 25, 50 and 200?mg/kg/day of nano copper, contents of copper shows trend of increasing in liver, kidney and intestinal; and ferrum shows gradually decreasing. The histopathological examination showed hemolysis, degeneration, nucleus pycnosis in liver, while renal tubular epithelial cell exfoliation and lymphocyte infiltration were found in kidney on supplementation of high concentration of nano-copper. Therefore, dietary supplementation of nano-copper 25?mg/kg b.wt could be a potential substitute for weaning piglets. 相似文献
7.
Afak Yusuf Sherwani Abdul Qayoom Shah Abdul Majeed Wani Ahmad Chalkoo Bashir Ahmad Khan Bashir Farooq Ahmad Sofi Ashfaq Amin Wani Wasim Lone Ab Hamid Sherwani Mehmood Rashid Sheikh Raj Reshi Sharma 《International journal of surgery case reports》2014,5(12):1285-1287
INTRODUCTION
Persistent Mullerian duct syndrome is a rare form of male pseudo-hermaphroditism characterized by the presence of Mullerian duct structures in an otherwise phenotypically, as well as genotypically, normal man; only a few cases have been reported in the worldwide literature. A great variety of organs have been found in indirect inguinal hernial sacs.PRESENTATION OF CASE
We report a case of 70 year old man, father of 4 children with unilateral cryptorchidism on the right side and left-sided obstructed inguinal hernia containing uterus and fallopian tube (that is, hernia uteri inguinalis; type I male form of persistent Mullerian duct syndrome) coincidentally detected during an operation for an obstructed left inguinal hernia.DISCUSSION
PMDS is usually coincidently detected during surgical operation, as was in our case. However pre-operative ultrasonography, computerized tomography and MRI allow possible pre-operative diagnosis.3CONCLUSION
In cases of unilateral or bilateral cryptorchidism associated with hernia, as in our patient''s case, the possibility of PMDS should be kept in mind. 相似文献8.
R. M. Arif Khalil Muhammad Iqbal Hussain Nadia Luqman Fayyaz Hussain Anwar Manzoor Rana Muhammad Saeed Akhtar Rana Farhat Mehmood 《RSC advances》2022,12(7):4395
The first-principles approach has been used while employing the Perdew–Burke–Ernzerhof exchange-correlation functional of generalized gradient approximation (PBE-GGA) along with the Hubbard parameter to study the structural, optoelectronic, mechanical and magnetic properties of titanium-based MAX materials Ti3AC2 (A = P, As, Cd) for the first time. As there is no band gap found between the valence and conduction bands in the considered materials, these compounds belong to the conductor family of materials. A mechanical analysis carried out at pressures of 0 GPa to 20 GPa and the calculated elastic constants Cij reveal the stability of these materials. Elastic parameters, i.e., Young''s, shear and bulk moduli, anisotropy factor and Poisson''s ratio, have been investigated in the framework of the Voigt–Reuss–Hill approximation. The calculated values of relative stiffness are found to be greater than ½ for Ti3PC2 and Ti3AsC2, which indicates that these compounds are closer to typical ceramics, which possess low damage tolerance and fracture toughness. Optical parameters, i.e., dielectric complex function, refractive index, extinction coefficient, absorption coefficient, loss function, conductivity and reflectivity, have also been investigated. These dynamically stable antiferromagnetic materials might have potential applications in advanced electronic and magnetic devices. Their high strength and significant hardness make these materials potential candidates as hard coatings.The first-principles approach has used the Perdew–Burke–Ernzerhof exchange-correlation functional of generalized gradient approximation along with the Hubbard parameter to study various properties of titanium-based MAX materials Ti3AC2 (A = P, As, Cd). 相似文献
9.
Sequence variants in nine different genes underlying rare skin disorders in 10 consanguineous families 下载免费PDF全文
Khadim Shah MPhil Sabba Mehmood MPhil Abid Jan PhD Izoduwa Abbe MS Raja Hussain Ali PhD Anwar Khan MPhil Muhammad S. Chishti PhD Kwanghyuk Lee MPhil Farooq Ahmad MPhil Muhammad Ansar PhD University of Washington Center for Mendelian Genomics Shaheen Shahzad PhD Deborah A. Nickerson PhD Michael J. Bamshad MD Paul J. Coucke PhD Regie L. P. Santos‐Cortez MD PhD Richard A. Spritz MD Suzanne M. Leal PhD Wasim Ahmad PhD 《International journal of dermatology》2017,56(12):1406-1413
10.