全文获取类型
收费全文 | 554篇 |
免费 | 22篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 21篇 |
妇产科学 | 26篇 |
基础医学 | 38篇 |
口腔科学 | 21篇 |
临床医学 | 76篇 |
内科学 | 79篇 |
皮肤病学 | 8篇 |
神经病学 | 28篇 |
特种医学 | 172篇 |
外科学 | 23篇 |
综合类 | 18篇 |
预防医学 | 47篇 |
药学 | 48篇 |
中国医学 | 1篇 |
肿瘤学 | 13篇 |
出版年
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 31篇 |
2014年 | 35篇 |
2013年 | 63篇 |
2012年 | 16篇 |
2011年 | 9篇 |
2010年 | 16篇 |
2009年 | 19篇 |
2008年 | 10篇 |
2007年 | 35篇 |
2006年 | 3篇 |
2005年 | 12篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 12篇 |
2001年 | 6篇 |
2000年 | 10篇 |
1999年 | 7篇 |
1998年 | 22篇 |
1997年 | 24篇 |
1996年 | 15篇 |
1995年 | 23篇 |
1994年 | 17篇 |
1993年 | 13篇 |
1992年 | 7篇 |
1991年 | 10篇 |
1990年 | 8篇 |
1989年 | 17篇 |
1988年 | 14篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1976年 | 10篇 |
1975年 | 3篇 |
1971年 | 3篇 |
1968年 | 3篇 |
1949年 | 4篇 |
1948年 | 3篇 |
1947年 | 6篇 |
1936年 | 2篇 |
1935年 | 2篇 |
1925年 | 2篇 |
1922年 | 2篇 |
1908年 | 2篇 |
排序方式: 共有623条查询结果,搜索用时 9 毫秒
1.
Rechtsanwalt Dr. iur. Matthias Dann LL.M. 《MedR Medizinrecht》2007,25(11):638-643
Ohne Zusammenfassung 相似文献
2.
J. KRØLL 《Scandinavian journal of immunology》1983,17(S10):171-173
3.
J. KRØLL 《Scandinavian journal of immunology》1983,17(S10):165-169
4.
J. KRØLL 《Scandinavian journal of immunology》1983,17(S10):135-139
5.
6.
7.
Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH; Washburn LL; McCarrey JR; Cattanach BM; Lovell-Badge R; Burgoyne PS 《Human molecular genetics》1998,7(4):715-727
An RNA-binding motif (RBM) gene family has been identified on the human Y
chromosome that maps to the same deletion interval as the 'azoospermia
factor' (AZF). We have identified the homologous gene family (Rbm) on the
mouse Y with a view to investigating the proposal that this gene family
plays a role in spermatogenesis. At least 25 and probably >50 copies of
Rbm are present on the mouse Y chromosome short arm located between Sry and
the centromere. As in the human, a role in spermatogenesis is indicated by
a germ cell-specific pattern of expression in the testis, but there are
distinct differences in the pattern of expression between the two species.
Mice carrying the deletion Yd1, that maps to the proximal Y short arm, are
female due to a position effect resulting in non-expression of Sry ;
sex-reversing such mice with an Sry transgene produces males with a high
incidence of abnormal sperm, making this the third deletion interval on the
mouse Y that affects some aspect of spermatogenesis. Most of the copies of
Rbm map to this deletion interval, and the Yd1males have markedly reduced
Rbm expression, suggesting that RBM deficiency may be responsible for, or
contribute to, the abnormal sperm development. In man, deletion of the
functional copies of RBM is associated with meiotic arrest rather than
sperm anomalies; however, the different effects of deletion are consistent
with the differences in expression between the two species.
相似文献
8.
Interchromosomal duplications of the adrenoleukodystrophy locus: a phenomenon of pericentromeric plasticity 总被引:13,自引:5,他引:13
Eichler EE; Budarf ML; Rocchi M; Deaven LL; Doggett NA; Baldini A; Nelson DL; Mohrenweiser HW 《Human molecular genetics》1997,6(7):991-1002
A 9.7 kb segment encompassing exons 7-10 of the adrenoleukodystrophy (ALD)
locus of the X chromosome has duplicated to specific locations near the
pericentromeric regions of human chromosomes 2p11,10p11, 16p11 and 22q11.
Comparative sequence analysis reveals 92-96% nucleotide identity,
indicating that the autosomal ALD paralogs arose relatively recently during
the course of higher primate evolution (5-10 million years ago). Analysis
of sequences flanking the duplication region identifies the presence of an
unusual GCTTTTTGC repeat which may be a sequence-specific integration site
for the process of pericentromeric- directed transposition. The breakpoint
sequence and phylogenetic analysis predict a two-step transposition model,
in which a duplication from Xq28 to pericentromeric 2p11 occurred once,
followed by a rapid distribution of a larger duplicon cassette among the
pericentromeric regions. In addition to facilitating more effective
mutation detection among ALD patients, these findings provide further
insight into the molecular basis underlying a pericentromeric-directed
mechanism for non- homologous interchromosomal exchange.
相似文献
9.
癌基因c-erbB-2在膀胱移行细胞癌中的扩增 总被引:2,自引:1,他引:1
0 引言 为探讨癌基因 c- erb B- 2的扩增与膀胱移行细胞癌(TCC)的关系 ,我们以斑点杂交的方法对 40例膀胱 TCC标本中 c- erb B- 2的扩增情况进行了检测 ,以期明确 c- erb B- 2扩增与膀胱 TCC病理分级及患者预后的关系 .1 材料和方法 40例膀胱 TCC患者术后石蜡包埋标本 ,随访 5~ 10 a. 11例正常膀胱粘膜石蜡标本作为对照 . c- erb B-c DNA p CER2 0 4质粒由东京大学提供 ,Bothringer缺口平移 DNA标记试剂盒及 32 P标记 d CTP购于北京福瑞公司 .所有石蜡标本经脱蜡及蛋白酶消化 ,以酚 /氯仿抽提 DNA,乙醇沉淀 .每份样品取… 相似文献
10.
Juan J. Tarin Josep LL. Romero Fernando Bonilla-Musoles 《Journal of assisted reproduction and genetics》1994,11(9):463-469
Purpose
To characterize and predict cycles generating slowcleaving embryos in in vitro fertilization, 86 cycles were retrospectively divided into two groups (slow, n=41, and fast, n=45 according to whether the number of blastomeres per embryo on day 3 was or > than the mean of the distribution, respectively.Results
Cycles generating slowcleaving embryos were treated with luteinizing hormonereleasing hormone agonist before ovarian stimulation for a shorter period (12.1±0.5 versus 15.6±1.1 days; P0.01) and had higher immaturity grade of oocyte-corona-cumulus complexes which resulted in embryos (1.6±0.1 vs 1.3±0.1; P0.05) when compared to cycles producing fastcleaving embryos. Both variables entered in a logistic regression model applied in order to predict the probability of a cycle generating slowcleaving embryos (goodness-of-fit chisquare=180.0, degrees of freedom (df)=80, P=0.4786. This model predicted correctly 86.7% (13 of 15) of cycles generating slowcleaving embryos and 83.3% (10 of 12) of cycles producing fastcleaving embryos when the estimated probability of a cycle producing slowcleaving embryos was 0.7 or 0.3, respectively.Conclusion
Shorter treatment with hormone-releasing hormone agonist before ovarian stimulation and higher immaturity grade of oocyte-corona-cumulus complexes which result in embryos are predictive characteristics of in vitro fertilization cycles generating slow-cleaving embryos. 相似文献