全文获取类型
收费全文 | 32027篇 |
免费 | 1534篇 |
国内免费 | 206篇 |
专业分类
耳鼻咽喉 | 205篇 |
儿科学 | 499篇 |
妇产科学 | 429篇 |
基础医学 | 3887篇 |
口腔科学 | 991篇 |
临床医学 | 2224篇 |
内科学 | 7971篇 |
皮肤病学 | 551篇 |
神经病学 | 2714篇 |
特种医学 | 1404篇 |
外科学 | 5452篇 |
综合类 | 127篇 |
预防医学 | 852篇 |
眼科学 | 512篇 |
药学 | 2326篇 |
中国医学 | 70篇 |
肿瘤学 | 3553篇 |
出版年
2023年 | 186篇 |
2022年 | 345篇 |
2021年 | 623篇 |
2020年 | 363篇 |
2019年 | 472篇 |
2018年 | 571篇 |
2017年 | 453篇 |
2016年 | 580篇 |
2015年 | 603篇 |
2014年 | 862篇 |
2013年 | 1018篇 |
2012年 | 1559篇 |
2011年 | 1764篇 |
2010年 | 919篇 |
2009年 | 842篇 |
2008年 | 1524篇 |
2007年 | 1561篇 |
2006年 | 1543篇 |
2005年 | 1608篇 |
2004年 | 1566篇 |
2003年 | 1500篇 |
2002年 | 1519篇 |
2001年 | 1014篇 |
2000年 | 1006篇 |
1999年 | 1026篇 |
1998年 | 452篇 |
1997年 | 348篇 |
1996年 | 334篇 |
1995年 | 258篇 |
1994年 | 234篇 |
1993年 | 223篇 |
1992年 | 695篇 |
1991年 | 607篇 |
1990年 | 630篇 |
1989年 | 615篇 |
1988年 | 520篇 |
1987年 | 473篇 |
1986年 | 470篇 |
1985年 | 418篇 |
1984年 | 294篇 |
1983年 | 250篇 |
1981年 | 99篇 |
1980年 | 98篇 |
1979年 | 247篇 |
1978年 | 150篇 |
1977年 | 132篇 |
1975年 | 106篇 |
1972年 | 106篇 |
1971年 | 105篇 |
1969年 | 102篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
Shoji Kubo Hiroaki Kinoshita Kazuhiro Hirohashi Takatsugu Yamamoto 《Journal of Hepato-Biliary-Pancreatic Surgery》1995,2(1):85-89
A case of cystadenocarcinoma of the liver is reported. The patient was a 73-year-old woman in whom a tumor was detected in
the lateral segment of the liver during a health examination. Ultrasonograms and computed tomograms showed a multilocular
cystic mass. Magnetic resonance imaging (MRI) showed a multilocular lowintensity mass, including a high-intensity portion
and a portal branch compressed by the tumor. MRI with gadolinium showed an enhanced cyst wall. The cystic part of the tumor
became smaller and the solid part became larger over a 1-month period, indicating that the tumor was malignant. Subsegmentectomy
(S3) was performed and cystadenocarcinoma with cystadenoma was diagnosed by histopathological examination. Identification of
changes in the appearance of a tumor should be helpful for the differential diagnosis of cystadenoma and cystadenocarcinoma. 相似文献
4.
Experiments were performed on spinalized rats, transected at the Cl level. The intravenous administration of TRH and its analog YM-14673 (N alpha-[(S)-4-oxo-2-azetidinyl) carbonyl]-L-histidyl-L-prolinamide dehydrate) produced marked increases in the amplitude of mono- and polysynaptic reflex potentials and those of the withdrawal flexor reflexes. The effects of YM-14673 were stronger and longer-lasting than those of TRH. The stimulant action of TRH and YM-14673 on the flexor reflexes was not antagonized by prazosin, chlorpromazine, haloperidol or cyproheptadine, suggesting no involvement of the release of catecholamines or serotonin in the stimulant effects of TRH and its analog. Therefore, YM-14673 may be beneficial for the treatment of several spinal motor neuron diseases. 相似文献
5.
S Yamada 《Journal of UOEH》1988,10(2):211-218
Physical activity and nutrition are the most important factors in preserving and/or improving health conditions. The relationship between exercise and nutrition is focused on two different directions: one is the direction toward health promoting, the other is for performance of a long heavy muscular work. For preserving and/or promoting health conditions, energy balance between intake and expenditure must be taken into account. The amount of glycogen stored in muscles is the essential factor to promote a long distance performance of working muscles. Topics that influence the energy balance and glycogen loading used by endurance athletes to improve performance are reviewed. 相似文献
6.
Basic fibroblast growth factor prevents thalamic degeneration after cortical infarction 总被引:10,自引:0,他引:10
K Yamada A Kinoshita E Kohmura T Sakaguchi J Taguchi K Kataoka T Hayakawa 《Journal of cerebral blood flow and metabolism》1991,11(3):472-478
In the focal infarction model of the rat middle cerebral artery (MCA), the thalamus of the occluded side becomes gradually atrophic, mainly because of retrograde degeneration. We determined whether basic fibroblast growth factor (bFGF) administered intracisternally could prevent this thalamic atrophy. We occluded the left MCA through a small cranial opening, and animals were then divided into two groups. One group received intracisternal injections of recombinant bFGF (1 microgram dissolved in 0.1 ml of saline with 2% rat serum) starting 1 day after occlusion and repeated once a week to a total dose of 4 micrograms by four injections. The other group received vehicle solution by the same schedule. The animals were perfused and fixed at 28 days after occlusion, and histological examination was made at the level of the caudoputamen and thalamus. In the bFGF-treated rats, the area of the posterior ventral thalamus of the occluded side was 93% of that of the contralateral side, i.e., significantly larger than in the normal saline-treated rats (75%, p less than 0.01). The infarction size was not statistically different in the two groups. Microscopic observation indicated that normal-saline-treated animals showed shrinkage and disappearance of thalamic neurons, whereas bFGF-treated groups showed preservation of thalamic neurons. Computerized analysis of the cell size substantiated this observation. To assess the effect of bFGF on astrocytes, bFGF or vehicle solution was injected into normal rats, and their histology was evaluated at 1, 2, and 4 weeks after injection. The bFGF-injected group showed a significant increase in glial fibrillary acidic protein-positive astrocytes in the brain tissue facing the ventriculocisternal system.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
7.
Severe myoclonic epilepsy (SMEI) or Dravet syndrome is caused by mutations of the SCN1A gene that encodes voltage-gated sodium channel alpha-1 subunit. Recently, we generated and characterized a knock-in (KI) mice with an SCN1A nonsense mutation that appeared in three independent SMEI patients. The SCN1A-KI mice well reproduced the SMEI disease phenotypes. Both homozygous and heterozygous knock-in mice developed epileptic seizures within the first postnatal month. In heterozygous knock-in mice, trains of evoked action potentials in inhibitory neurons exhibited pronounced spike amplitude decrement late in the burst but not in pyramidal neurons. We further showed that in wild-type mice the Nav1.1 protein is expressed dominantly in axons and moderately in somata of parbalbumin (PV) – positive inhibitory interneurons. Our immunohistochemical observations of the Nav1.1 are clearly distinct to the previous studies, and our findings has corrected the view of the Nav1.1 protein distribution. The data indicate that Nav1.1 plays critical roles in the spike output from PV interneurons and further, that the specifically altered function of these inhibitory circuits may contribute to epileptic seizures in the mice. These information should contribute to the understanding of molecular pathomechanism of SMEI and to develop its effective therapies. 相似文献
8.
9.
10.