全文获取类型
收费全文 | 656篇 |
免费 | 24篇 |
国内免费 | 5篇 |
专业分类
儿科学 | 16篇 |
妇产科学 | 2篇 |
基础医学 | 73篇 |
口腔科学 | 6篇 |
临床医学 | 29篇 |
内科学 | 81篇 |
皮肤病学 | 12篇 |
神经病学 | 99篇 |
特种医学 | 58篇 |
外科学 | 53篇 |
综合类 | 25篇 |
一般理论 | 3篇 |
预防医学 | 151篇 |
眼科学 | 2篇 |
药学 | 46篇 |
肿瘤学 | 29篇 |
出版年
2023年 | 4篇 |
2022年 | 5篇 |
2021年 | 7篇 |
2020年 | 6篇 |
2019年 | 7篇 |
2018年 | 13篇 |
2017年 | 13篇 |
2016年 | 9篇 |
2015年 | 14篇 |
2014年 | 15篇 |
2013年 | 26篇 |
2012年 | 28篇 |
2011年 | 30篇 |
2010年 | 32篇 |
2009年 | 31篇 |
2008年 | 32篇 |
2007年 | 33篇 |
2006年 | 31篇 |
2005年 | 33篇 |
2004年 | 36篇 |
2003年 | 16篇 |
2002年 | 15篇 |
2001年 | 14篇 |
2000年 | 20篇 |
1999年 | 13篇 |
1998年 | 27篇 |
1997年 | 23篇 |
1996年 | 11篇 |
1995年 | 13篇 |
1994年 | 11篇 |
1993年 | 12篇 |
1992年 | 12篇 |
1991年 | 6篇 |
1990年 | 12篇 |
1989年 | 17篇 |
1988年 | 10篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1968年 | 1篇 |
1966年 | 2篇 |
排序方式: 共有685条查询结果,搜索用时 15 毫秒
1.
2.
3.
Hillary R Bogner Mark S Cary Martha L Bruce Charles F Reynolds Benoit Mulsant Thomas Ten Have George S Alexopoulos 《The American journal of geriatric psychiatry》2005,13(10):861-868
OBJECTIVE: The authors described the influence of specific medical conditions on clinical remission and response of major depression (MDD) in a clinical trial evaluating a care-management intervention among older primary-care patients. METHODS: Adults age 60 years and older were randomly selected and screened for depression. Participants were randomly assigned to Usual Care or to an Intervention with a depression care-manager offering algorithm-based care for MDD. In all, 324 adults meeting criteria for MDD were included in these analyses. Remission and response was defined by a score on the Hamilton Rating Scale for Depression <10 and by a decrease from baseline of > or =50%, respectively. Medical comorbidity was ascertained through self-report. Cognitive impairment was defined by a score <24 on the Mini-Mental State Exam (MMSE). RESULTS: In Usual Care, rates of remission were faster in persons who reported atrial fibrillation (AF) than in persons who did not report AF and slower in persons who reported chronic pulmonary disease than in persons who did not report chronic pulmonary disease; rates of response were less stable in persons with MMSE <24 than in those with MMSE > or =24. In the Intervention condition, none of the specific chronic medical conditions were significantly associated with outcomes for MDD. CONCLUSIONS: Because disease-specific findings were observed in persons who received Usual Care but not in persons who received more intensive treatment in the Intervention condition, our results suggest that the association of medical comorbidity and treatment outcomes for MDD may be determined by the intensity of treatment for depression. 相似文献
4.
5.
Infection studies with canine distemper virus in harbour seals 总被引:1,自引:0,他引:1
V. Svansson M. Blixenkrone-Møller K. Skirnisson P. Have N. -I. Heje J. Nielsen E. Lund 《Archives of virology》1993,131(3-4):349-359
Summary Infection studies in harbour seal (Phoca vitulina) were conducted with the Snyder-Hill strain of canine distemper virus (CDV) that is virulent for dog and mink. The inoculated seals showed clinical symptoms which were to some degree similar to those observed in CDV infections of sensitive species of carnivores. Viral replication in lymphoid cells was followed by an extended period of immunosuppression. The results did not provide conclusive evidence for viral replication in surface epithelia of seals, and accordingly no spread of the infection to contact seals and mink was demonstrated. The pathogenicity of the infection did not increase upon a second viral passage in seal. The serological data showed that CDV-infected seals mounted an early virus specific antibody response. Overall, the results indicated that the harbour seal was not especially sensitive to CDV infection. The differences in the in vivo biological properties of CDV and PDV add to the distinction between these viruses at the genomic and antigenic levels. 相似文献
6.
7.
Emet D. Schneiderman Stephen M. Willis Charles J. Kowalski Thomas R. Ten Have 《American journal of human biology》1992,4(3):399-401
A method for computing a measure of tracking based on Cohen's kappa statistic for one-sample longitudinal data sets was previously described and implemented. This paper shows how one may test the equality of several kappas, each computed from an independent longitudinal sample. Thus, it is possible to formally compare groups of individuals with regard to stability in growth (or adaptive) patterns. Relative assessments of predictability in growth outcomes in different populations can be made with this approach. Also, when a common value of kappa is not contradicted by the data, a method to estimate this value and obtain a confidence interval for it is shown. A menu-driven GAUSS program for carrying out the procedure is described and made available. The method and program are illustrated with three samples of Guatemalan children. © 1992 Wiley-Liss, Inc. 相似文献
8.
Emet D. Schneiderman Charles J. Kowalski Thomas R. Ten Have 《American journal of human biology》1990,2(5):475-490
Tracking can be defined as the tendency of individuals or collections of individuals to stay within a particular course of growth over time relative to other individuals. Thus, tracking describes stability in growth patterns. This paper outlines a statistical procedure for examining tracking in a single sample of measurements made on humans or other animals. This nonparametric procedure, based on Cohen's (1960) kappa statistic, is suitable for equally or unequally spaced serial data that is complete and is appropriate for questions concerning growth as well as other time-dependent phenomena. It is a conceptually simple longitudinal method that affords insight regarding the predictability of growth within a population. For example, by tracking, one can ask if young children who are in the lowest height for age category are likely to end up in that category at an older age. A user-friendly GAUSS program is provided that generates overall as well as individual and track-specific statistics. High-resolution graphic representations of the data are also generated by the program. Examples are presented, including a tracking analysis of Guatemalan Indian children using quartiles. 相似文献
9.
Terry?O?Herndon Salvador?Gonzalez TR?Gowrishankar R?Rox?Anderson James?C?WeaverEmail author 《BMC medicine》2004,2(1):12
Background
Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum and epidermis is achieved by stochastic scissioning events localized to typically 250 μm diameter areas of human skin in vivo. 相似文献10.
Kumanyika SK Adams-Campbell L Van Horn B Ten Have TR Treu JA Askov E Williams J Achterberg C Zaghloul S Monsegu D Bright M Stoy DB Malone-Jackson M Mooney D Deiling S Caulfield J 《Journal of the American Dietetic Association》1999,99(11):1380-1391
OBJECTIVE: To evaluate a cardiovascular nutrition education package designed for African-American adults with a wide range of literacy skills. DESIGN: Comparison of a self-help group and a full-instruction group; each group received nutrition counseling and clinical monitoring every 4 months. SUBJECTS: Three hundred thirty African-American adults, aged 40 to 70 years, with elevated cholesterol level or high blood pressure were randomly assigned to the self-help or full-instruction group; 255 completed the 12-month follow-up. INTERVENTIONS: Counseling to reduce intake of dietary fat, cholesterol, and sodium was based on Cardiovascular Dietary Education System (CARDES) materials, which included food-picture cards, a nutrition guide (self-help and full-instruction group), a video and audiotape series, and 4 classes (full-instruction group only). MAIN OUTCOME MEASURES: Changes in lipid levels and blood pressure after 12 months. STATISTICAL ANALYSES PERFORMED: Primary analyses consisted of repeated-measures analysis of variance to examine effects of time and randomization group on outcomes. RESULTS: Total cholesterol and low-density lipoprotein cholesterol level decreased by 7% to 8% in the self-help and full-instruction groups of men and women (P < .01). The ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C) decreased in both groups of women and in the men in the full-instruction group (P < .01). In full-instruction and self-help participants with elevated blood pressure at baseline, systolic blood pressure decreased by 7 to 11 mm Hg and diastolic blood pressure decreased by 4 to 7 mm Hg (P < .01). Outcomes did not differ by literacy scores but were positively related to the reported initial frequency of using CARDES materials. APPLICATIONS/CONCLUSIONS: These results suggest that periodic nutrition counseling based on CARDES materials used for home study can enhance management of lipid levels and blood pressure in African-American outpatients. 相似文献