全文获取类型
收费全文 | 27365篇 |
免费 | 1353篇 |
国内免费 | 254篇 |
专业分类
耳鼻咽喉 | 242篇 |
儿科学 | 547篇 |
妇产科学 | 639篇 |
基础医学 | 2922篇 |
口腔科学 | 531篇 |
临床医学 | 2345篇 |
内科学 | 7913篇 |
皮肤病学 | 573篇 |
神经病学 | 2438篇 |
特种医学 | 966篇 |
外科学 | 4435篇 |
综合类 | 63篇 |
一般理论 | 5篇 |
预防医学 | 1004篇 |
眼科学 | 347篇 |
药学 | 1453篇 |
中国医学 | 45篇 |
肿瘤学 | 2504篇 |
出版年
2024年 | 30篇 |
2023年 | 228篇 |
2022年 | 479篇 |
2021年 | 822篇 |
2020年 | 507篇 |
2019年 | 667篇 |
2018年 | 804篇 |
2017年 | 614篇 |
2016年 | 750篇 |
2015年 | 824篇 |
2014年 | 1050篇 |
2013年 | 1420篇 |
2012年 | 2201篇 |
2011年 | 2146篇 |
2010年 | 1264篇 |
2009年 | 1143篇 |
2008年 | 1975篇 |
2007年 | 1869篇 |
2006年 | 1700篇 |
2005年 | 1723篇 |
2004年 | 1573篇 |
2003年 | 1385篇 |
2002年 | 1275篇 |
2001年 | 172篇 |
2000年 | 126篇 |
1999年 | 171篇 |
1998年 | 223篇 |
1997年 | 208篇 |
1996年 | 162篇 |
1995年 | 189篇 |
1994年 | 153篇 |
1993年 | 143篇 |
1992年 | 96篇 |
1991年 | 81篇 |
1990年 | 93篇 |
1989年 | 54篇 |
1988年 | 46篇 |
1987年 | 38篇 |
1986年 | 50篇 |
1985年 | 52篇 |
1984年 | 58篇 |
1983年 | 42篇 |
1982年 | 53篇 |
1981年 | 32篇 |
1980年 | 44篇 |
1979年 | 29篇 |
1978年 | 15篇 |
1977年 | 17篇 |
1975年 | 19篇 |
1974年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Exhaled nitric oxide in children with allergic rhinitis: A potential biomarker of asthma development 下载免费PDF全文
2.
3.
4.
5.
6.
Khalil Fattouch Giuseppe Bianco Giuseppe Speziale Roberta Sampognaro Carlo Lavalle Francesco Guccione Pietro Dioguardi Giovanni Ruvolo 《European journal of cardio-thoracic surgery》2007,32(2):326-332
BACKGROUND: The inflammatory cascade has been hypothesized to be an important mechanism of post-ischaemic myocardial reperfusion injury and several studies demonstrated that C1 esterase inhibitor (C1-INH) is effective in post-ischaemia myocardial protection. Therefore, we aimed to investigate prospectively in a randomised double-blind study the cardioprotective effects of C1-INH in ST segment elevation myocardial infarction (STEMI) in patients who underwent emergent reperfusion with coronary artery bypass grafting (CABG). METHODS: In this study, we enrolled 80 patients affected with STEMI who underwent emergent CABG. Patients were assigned in two groups (C1-INH group: receive 1000 UI of C1-INH; and placebo group: receive a saline solution). The effects of C1-INH on complement inhibition, myocardial cell injury extension and clinical outcome were studied. Haemodynamic data and myocardial function were monitored. C1-INH, C3a, C4a complement activation fragments and cardiac troponin I (cTnI) serum levels were measured before, during and after surgery. RESULTS: Patient characteristics were not different between the two groups. The overall in-hospital mortality rate was 6.2%. No statistical significant difference was observed between the two groups with regard to early mortality (p=0.36). Statistical significant difference between the two groups was showed for cardiopulmonary bypass support (p=0.04), administration of high dose of inotropes drugs (p=0.001), time of intubation (p=0.03), intensive care unit (ICU) stay (p=0.04) and in-hospital stay (p=0.03). A significant improvement in mean arterial pressure (p=0.03), cardiac index (p=0.02) and stroke volume (p=0.03) was showed in C1-INH group versus placebo group. The serum cTnI levels were significantly low in the C1-INH group versus placebo group after reperfusion, during the observation period. Plasma levels of C3a and C4a complement fragments were reduced significantly in C1-INH group. No drugs-related adverse effects were observed. CONCLUSIONS: The inhibition of the classic complement pathway by C1-INH appears to be an effective mean of preserving ischaemic myocardium from reperfusion injury as demonstrated by low serum cTnI levels in C1-INH group. Therefore, the use of C1-INH during CABG as a rescue therapy in STEMI patients is probably an effective treatment to inhibit complement activity and to improve cardiac function and haemodynamic performance without impacting early mortality. Large randomised study should be performed to support our results. 相似文献
7.
Andrea Salonia MD Alberto Briganti MD Andrea Gallina MD Giuseppe Zanni MD Federico Dehò MD Patrizio Rigatti MD Francesco Montorsi MD 《Current Sexual Health Reports》2007,4(2):85-90
This article assesses the effects of lower urinary tract symptoms (LUTS), not including urinary incontinence, on the overall
sexual health of women, using literature that includes peer-reviewed articles. This article analyzes a number of studies that
provide data on the prevalence and the predictors of sexual function impairment in women with LUTS, such as urinary urgency
and frequency, overactive bladder syndrome, and interstitial cystitis. Because case studies provide substantial heterogeneity
of outcome measures, this article does not apply meta-analytic techniques to the data. Most of the studies showed that LUTS
can have a negative impact on the sexual health of women, sexual pain disorder being the more frequent complaint among patients
with bladder dysfunctions. 相似文献
8.
Sergi Sastre Francisco Maculé Sandra Lasurt Josep-María Segur Lluis Lozano Montse Nuñez Santiago Suso 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2007,17(4):393-397
Five patients with idiopathic transient osteoporosis were examined. Bone scanning and MRI was helpful in the diagnosis to differentiate of necrosis and all patients recovered completely with conservative and symptomatic treatment. There was no history of trauma in all patients. MRI was realized previously in all cases to confirm the diagnosis and after the resolution of symptomathology. 相似文献
9.
Rebecca Voltan Arianna Castaldello Egidio Brocca-Cofano Rita De Michele Chiara Triulzi Giuseppe Altavilla Luisa Tondelli Michele Laus Katia Sparnacci Eva Reali Riccardo Gavioli Barbara Ensoli Antonella Caputo 《Vaccine》2009
Cationic block copolymers spontaneously assemble via electrostatic interactions with DNA molecules in aqueous solution giving rise to micellar structures that protect the DNA from enzymatic degradation both in vitro and in vivo. In addition, we have previously shown that they are safe, not immunogenic and greatly increased antigen-specific CTL responses following six intramuscular inoculations of a very low dose (1 μg) of the vaccine DNA as compared to naked DNA. Nevertheless, they failed to elicit detectable humoral responses against the antigen. To gain further insight in the potential application of this technology, here we show that a shorter immunization protocol based on two DNA intramuscular inoculations of 1 μg of DNA delivered by these copolymers and a protein boost elicits in mice broad (both humoral and cellular) and long-lasting responses and increases the antigen-specific Th1-type T cell responses and CTLs as compared to priming with naked DNA. These results indicate that cationic block copolymers represent a promising adjuvant and delivery technology for DNA vaccination strategies aimed at combating intracellular pathogens. 相似文献
10.
Giuseppe Lippi Gian Luca Salvagno Martina Montagnana Franco Manzato Gian Cesare Guidi 《Blood coagulation & fibrinolysis》2007,18(5):525-528
Preparation of blood specimens is a major bottleneck in the laboratory throughput. Reliable strategies for reducing the time required for specimen processing without affecting quality should be acknowledged, especially for laboratories performing stat analyses. The present investigation was planned to establish a minimal suitable centrifuge time for primary samples collected for routine coagulation testing. Five sequential primary vacuum tubes containing 0.109 mol/l buffered trisodium citrate were collected from 10 volunteers and were immediately centrifuged on a conventional centrifuge at 1500 x g, at room temperature for 1, 2, 5, 10 and 15 min, respectively. Hematological and routine coagulation testing, including prothrombin time, activated partial thromboplastin time and fibrinogen, were performed. The centrifugation time was inversely associated with residual blood cell elements in plasma, especially platelets. Statistically significant variations from the reference 15-min centrifuge specimens were observed for fibrinogen in samples centrifuged for 5 min at most and for the activated partial thromboplastin time in samples centrifuged for 2 min at most. Meaningful biases related to the desirable bias were observed for fibrinogen in samples centrifuged for 2 min at most, and for the activated partial thromboplastin time in samples centrifuged for 1 min at most. According to our experimental conditions, a 5-10 min centrifuge time at 1500 x g may be suitable for primary tubes collected for routine coagulation testing. 相似文献