全文获取类型
收费全文 | 993篇 |
免费 | 49篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 43篇 |
妇产科学 | 5篇 |
基础医学 | 80篇 |
口腔科学 | 6篇 |
临床医学 | 77篇 |
内科学 | 242篇 |
皮肤病学 | 32篇 |
神经病学 | 56篇 |
特种医学 | 53篇 |
外国民族医学 | 10篇 |
外科学 | 194篇 |
综合类 | 6篇 |
预防医学 | 129篇 |
眼科学 | 2篇 |
药学 | 29篇 |
肿瘤学 | 73篇 |
出版年
2023年 | 7篇 |
2022年 | 14篇 |
2021年 | 33篇 |
2020年 | 16篇 |
2019年 | 33篇 |
2018年 | 46篇 |
2017年 | 21篇 |
2016年 | 31篇 |
2015年 | 23篇 |
2014年 | 31篇 |
2013年 | 60篇 |
2012年 | 74篇 |
2011年 | 85篇 |
2010年 | 44篇 |
2009年 | 47篇 |
2008年 | 64篇 |
2007年 | 56篇 |
2006年 | 66篇 |
2005年 | 49篇 |
2004年 | 36篇 |
2003年 | 32篇 |
2002年 | 41篇 |
2001年 | 13篇 |
2000年 | 5篇 |
1999年 | 13篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 8篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1983年 | 5篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 4篇 |
1969年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有1043条查询结果,搜索用时 78 毫秒
1.
The authors report the results of the Patterns of Care for Brachytherapy in Europe (PCBE) throughout France. Responses were obtained for 91% of the Radiation Oncology departments, which have declared using brachytherapy for 67, and gave detailed data for 49 ones. The equipments and treated tumours were recorded. LDR brachytherapy remained the most often used (53.5%), followed by HDR (28%). PDR represented 5.5% and permanent implants 11%. The authors discuss the development of new equipment, with an aggregation of the structures, and an increase of the PDR and prostate implants use. 相似文献
2.
Drug-resistance in Streptococcus pneumoniae isolates among Spanish middle aged and older adults with community-acquired pneumonia 总被引:1,自引:0,他引:1
Angel Vila-Corcoles Ferran Bejarano-Romero Elisabeth Salsench Olga Ochoa-Gondar Cinta de Diego Frederic Gomez-Bertomeu Xavier Raga-Luria Xavier Cliville-Guasch Victoria Arija 《BMC infectious diseases》2009,9(1):36
Background
Pneumococcal diseases remain a major cause of morbidity and mortality worldwide. Updated data on drug-resistance from different populations may be important to recognize changes in disease patterns. This study assessed current levels of penicilin resistance among Streptococcus Pneumoniae causing pneumonia in Spanish middle age and older adults. 相似文献3.
4.
Corticosteroid inhibition of the OKT3-induced cytokine-related syndrome--dosage and kinetics prerequisites 总被引:2,自引:0,他引:2
The data presented extend to a larger series of 27 consecutive renal allograft recipients treated prophylactically with OKT3 our previous observation that the acute OKT3-induced clinical syndrome is related to massive release in the circulation of some cytokines, among which are tumor necrosis factor and interferon gamma. In addition, a pilot randomized study was set up including 12 consecutive patients receiving high-dose corticosteroid treatment (0.5 g solumedrol) either before or at the same time as the first OKT3 injection. Results confirm that when corticosteroids are given in sufficient amount and, importantly, 1 hr before the first OKT3 injection, they significantly decrease the release of both tumor necrosis factor and interferon gamma. In addition, the pretreatment with corticosteroids may totally abolish the IL-2 release induced by OKT3. Given the key role the massive although transient cytokine release plays in determining the OKT3-induced acute syndrome, these results provide the biological basis supporting a precise kinetics of administration of high-dose corticosteroids to better decrease the severity of the clinical reaction. 相似文献
5.
6.
Plana M Garcia F Oxenius A Ortiz GM Lopez A Cruceta A Mestre G Fumero E Fagard C Sambeat MA Segura F Miró JM Arnedo M Lopalcos L Pumarola T Hirschel B Phillips RE Nixon DF Gallart T Gatell JM 《Journal of acquired immune deficiency syndromes (1999)》2004,36(3):791-799
OBJECTIVES: To analyze the dynamics of both HIV-1-specific CD4 and CD8 T-cell responses during structured treatment interruptions (STIs) in chronically HIV-1-infected (CHI) patients and to correlate them with the viral set point achieved. METHODS: Forty-five early-stage CHI patients who were on highly active antiretroviral therapy (HAART) for at least 1 year and underwent STI were included. Plasma viral load (VL), peripheral blood mononuclear cell (PBMC) lymphoproliferative (LPR) response to HIV p24 protein, and HIV-1 epitope-specific interferon-gammarelease from CD8 T cells were measured over a minimum study period of 2 years. RESULTS: VL set point during final STI was both significantly lower than, and positively correlated to, baseline VL (P < 0.0001: mean VL reduction 0.77 log10, and r = 0.42, P = 0.004, respectively). CD4 LPRs to p24 increased significantly (P = 0.001) between day 0 of the first STI cycle and 4th STI but decreased thereafter. VL set point during final STI was significantly and negatively correlated with LPRs to p24 at both 2nd STI and 4th STI. Nevertheless, at week 52, 12 weeks after the end of the last STI, LPRs were weak and transient in all patients and were not correlated with VL set point. Moreover, the magnitude and breadth of HIV-1-specific CD8 T-cell responses increased significantly (P < 0.0001) between day 0 and week 52. The largest increases occurred during the final STI. Even though VL reached set point by week 12 of the final STI, HIV-1-specific CD8 T-cell responses did not stabilize but rather increased until the end of the follow-up and did not correlate with plasma VL (r = 0.01, P = 0.88). CONCLUSIONS: STIs do not lead to control of viral replication in CHI patients, probably due to the fact that boosted CTL responses lack strong and durable helper T-cell responses. To reset the VL set point, new approaches that effectively augment and preserve helper T-cell responses should be investigated. 相似文献
7.
8.
9.
10.