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1.
CM Reid M. Nelson P. Beckinsale P. Ryan LMH Wing LJ Beilin MA Brown GLR Jennings CI Johnston J. Marley JJ McNeil TO Morgan J. Shaw ID Steven MJ West 《Clinical and experimental pharmacology & physiology》1997,24(5):370-373
1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was 160 mmHg systolic or 90 mmHg diastolic if systolic BP was 140 mmHg. 3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP 5=160/90 mmHg. Forty-seven percent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty-seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population). 4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial. 相似文献
2.
Physical inactivity, excess adiposity and premature mortality 总被引:5,自引:0,他引:5
The purpose of this report is to review the evidence that physical inactivity and excess adiposity are related to an increased risk of all‐cause mortality, and to better identify the independent contributions of each to all‐cause mortality rates. A variance‐based method of meta‐analysis was used to summarize the relationships from available studies. The summary relative risk of all‐cause mortality for physical activity from the 55 analyses (31 studies) that included an index of adiposity as a covariate was 0.80 [95% confidence interval (CI) 0.78–0.82], whereas it was 0.82 [95% CI 0.80–0.84] for the 44 analyses (26 studies) that did not include an index of adiposity. Thus, physically active individuals have a lower risk of mortality by comparison to physically inactive peers, independent of level of adiposity. The summary relative risk of all‐cause mortality for an elevated body mass index (BMI) from the 25 analyses (13 studies) that included physical activity as a covariate was 1.23 [95% CI 1.18–1.29], and it was 1.24 [95% CI 1.21–1.28] for the 81 analyses (36 studies) that did not include physical activity as a covariate. Studies that used a measure of adiposity other than the BMI show similar relationships with mortality, and stratified analyses indicate that both physical inactivity and adiposity are important determinants of mortality risk. 相似文献
3.
肌病肾病代谢综合征治疗进展 总被引:1,自引:0,他引:1
肌病肾病代谢综合征是急性动脉阻塞致骨骼肌溶解的严重并发症。积极治疗原发病,及早补液扩容、碱化尿液、早期血液净化治疗是降低截肢率、病死率的关键。本文就肌病肾病代谢综合征治疗进展作一综述。 相似文献
4.
肝尾状叶由于解剖位置特殊,位置深,难以显露,手术难度大,是肝脏外科领域手术操作的难点与研究热点.随着肝血流控制技术的发展、肝实质离断技术的提高,肝尾状叶肿瘤切除率明显提高[1].2006年4月至2008年10月,我科完成单独肝尾状叶血管瘤切除术9例,现将手术技巧与疗效报道如下. 相似文献
5.
Vascular networks of the nucleus lentiformis 总被引:3,自引:0,他引:3
Summary The nucleus lentiformis vascular networks were studied in 30 brains by injecting the vascular system with gelatinous Indian ink. The nucleus lentiformis is divided into a medial part, the globus pallidus, and a lateral part, the putamen. These two parts differ completely from one another in their embryology, structure and functions. For these reasons, each part presents a specific vascular network. The putaminal network is dense and shows many similarities with the cerebral cortex vascular network; the pallidal one is simpler and less dense. These two vascular networks are located close to each other without overlapping. Their specificity may be in relation with the histological structure, with the morphogenetic evolution or with the functional activity of both nuclei to which they provide the vascularization.
Les réseaux vascularies du noyau lenticulaire
Résumé L'étude des réseaux vasculaires du noyau lenticulaire (NL) est réalisée sur 30 cerveaux dont le système vasculaire a été injecté à l'encre de Chine gélosée. Le NL est constitué par deux parties, le putamen (néostriatum) et le globus pallidus (paléo-striatum), totalement différentes sur les plans morphologique, embryologique et fonctionnel. Chacune de ces parties possède un réseau vasculaire spécifique et caractéristique. Les deux réseaux se côtoient sans se chevaucher. Le réseau vasculaire putaminal est dense et présente de nombreuses similitudes avec le réseau vasculaire du cortex cérébral. Le réseau vasculaire pallidal se caractérise par sa simplicité et sa moindre densité. Leur spécificité peut être en rapport avec la structure histologique, l'évolution morphogénétique et avec l'activité fonctionnelle des noyaux dont ils assurent l'irrigation.相似文献
6.
L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns 总被引:8,自引:3,他引:8
Fransen E; D'Hooge R; Van Camp G; Verhoye M; Sijbers J; Reyniers E; Soriano P; Kamiguchi H; Willemsen R; Koekkoek SK; De Zeeuw CI; De Deyn PP; Van der Linden A; Lemmon V; Kooy RF; Willems PJ 《Human molecular genetics》1998,7(6):999-1009
L1 is a neural cell adhesion molecule mainly involved in axon guidance and
neuronal migration during brain development. Mutations in the human L1 gene
give rise to a complex clinical picture, with mental retardation,
neurologic abnormalities and a variable degree of hydrocephalus. Recently,
a transgenic mouse model with a targeted null mutation in the L1 gene was
generated. These knockout (KO) mice show hypoplasia of the corticospinal
tract. Here we have performed further studies of these KO mice including
magnetic resonance imaging of the brain, neuropathological analysis and
behavioral testing. The ventricular system was shown to be abnormal with
dilatation of the lateral ventricles and the 4th ventricle, and an altered
shape of the Sylvius aqueduct. Additionally, the cerebellar vermis of the
KO mice is hypoplastic. Their exploratory behavior is characterized by
stereotype peripheral circling reminiscent of that of rodents with induced
cerebellar lesions.
相似文献
7.
咪唑斯汀治疗慢性荨麻疹临床疗效评价及对血清IL-4水平的影响 总被引:2,自引:0,他引:2
目的:评价咪唑斯汀治疗慢性荨麻疹的疗效,探讨IL-4在慢性荨麻疹发病中的作用。方法:对32例慢性荨麻疹患用咪唑斯汀治疗,评价疗效,记录不良反应。同时用ELISA法检测慢性荨麻疹患治疗前后及正常人血清IL-4的水平。结果:治疗1、2wk后总有效率分别为62.5%、84.4%(P<0.01),不良反应3例。治疗前血清IL-4水平较正常人明显升高(P<0.01);治疗后IL-4水平下降(P<0.01),与正常人比较差异不甚明显(P>0.05)。结论:咪唑斯汀是一种有效、安全的治疗慢性荨麻疹的药物,能降低慢性荨麻疹患血清IL-4的水平。 相似文献
8.
硫酸镁对普鲁帕酮致心律失常的干预作用 总被引:1,自引:0,他引:1
目的探讨静脉滴注硫酸镁对普鲁帕酮致心律失常作用的干预效果。方法将92例心律失常患者随机分为对照组和干预组,每组46例。两组均口服普鲁帕酮,干预组同时静脉滴注硫酸镁,于治疗1周后常规心电图观察心律失常变化及致心律失常作用。结果心律失常消失率对照组为43.4%(20/46)、干预组为82.6%(39/46),致心律失常率对照组为19.6%、干预组为4.4%,两组比较有统计学意义(P<0.01)。结论普鲁帕酮抗心律失常同时有致心律失常作用,使用硫酸镁干预可降低致心律失常发生率。 相似文献
9.
目的:观察乌龙丹联合柳氮磺吡啶治疗强直性脊柱炎的疗效与安全性。方法:66例门诊患者随机分为治疗组36例和对照组30例,治疗组给予乌龙丹联合柳氮磺吡啶治疗,对照组给予柳氮磺吡啶治疗,两组均在必要时给予NSAIDs治疗并记录剂量及用药天数。观察治疗前后两组患者临床疗效及实验室指标改变情况。结果:治疗12周后,两组患者在晨僵时间、ESR、CRP、BASFI、BASDAI均比治疗前有显著改善(P<0.05),且治疗组优于对照组(P<0.05)。治疗组有效率高于对照组(P<0.05),且不良反应较对照组少( P<0.05)。结论:乌龙丹联合柳氮磺吡啶治疗强直性脊柱炎有良好疗效。 相似文献
10.
目的:通过检测正常人群、梅毒未治疗患者、梅毒治疗后非梅毒螺旋体抗原血清试验转阴患者和梅毒血清固定患者血清IL-10、IL-12水平,并对梅毒血清固定患者血清IL-10和IL-12作相关性分析。以探讨细胞免疫与梅毒血清固定的关系,为有效治疗梅毒血清固定患者提供一定的理论依据。方法:采用双抗体夹心ELISA法分别检测正常人群组、梅毒未治疗组、梅毒治疗转阴组和梅毒血清固定组的IL-10和IL-12水平,将各组IL-10和IL-12水平行统计学分析。对梅毒血清固定组中IL-10与IL-12作相关性分析。结果:梅毒血清固定组患者IL-10水平显著高于正常对照组(P<0.01)、治疗后阴转组(P<0.01)及梅毒未治疗组(P<0.05);梅毒血清固定组患者IL-12水平与正常对照组、治疗后阴转组及梅毒未治疗组之间差异无显著性(P>0.05);梅毒血清固定组患者IL-10与IL-12水平之间无明显相关性(r=0.417,P>0.05)。结论:梅毒血清固定组患者机体内细胞免疫受到一定程度的抑制,发生了免疫不平衡,这种免疫抑制和不平衡可能造成了梅毒螺旋体能够逃脱机体的免疫监视而残存,成为引起血清固定的原因之一。 相似文献