全文获取类型
收费全文 | 19894篇 |
免费 | 1844篇 |
国内免费 | 1249篇 |
专业分类
耳鼻咽喉 | 187篇 |
儿科学 | 284篇 |
妇产科学 | 242篇 |
基础医学 | 2228篇 |
口腔科学 | 393篇 |
临床医学 | 2574篇 |
内科学 | 2937篇 |
皮肤病学 | 233篇 |
神经病学 | 972篇 |
特种医学 | 678篇 |
外国民族医学 | 3篇 |
外科学 | 2105篇 |
综合类 | 3426篇 |
现状与发展 | 4篇 |
一般理论 | 6篇 |
预防医学 | 1547篇 |
眼科学 | 503篇 |
药学 | 1859篇 |
23篇 | |
中国医学 | 1264篇 |
肿瘤学 | 1519篇 |
出版年
2024年 | 81篇 |
2023年 | 321篇 |
2022年 | 826篇 |
2021年 | 1004篇 |
2020年 | 741篇 |
2019年 | 591篇 |
2018年 | 657篇 |
2017年 | 560篇 |
2016年 | 546篇 |
2015年 | 775篇 |
2014年 | 879篇 |
2013年 | 979篇 |
2012年 | 1422篇 |
2011年 | 1487篇 |
2010年 | 1067篇 |
2009年 | 930篇 |
2008年 | 1173篇 |
2007年 | 1186篇 |
2006年 | 1134篇 |
2005年 | 985篇 |
2004年 | 767篇 |
2003年 | 753篇 |
2002年 | 657篇 |
2001年 | 502篇 |
2000年 | 513篇 |
1999年 | 422篇 |
1998年 | 263篇 |
1997年 | 228篇 |
1996年 | 183篇 |
1995年 | 195篇 |
1994年 | 151篇 |
1993年 | 85篇 |
1992年 | 133篇 |
1991年 | 110篇 |
1990年 | 88篇 |
1989年 | 79篇 |
1988年 | 79篇 |
1987年 | 71篇 |
1986年 | 56篇 |
1985年 | 49篇 |
1984年 | 39篇 |
1983年 | 26篇 |
1982年 | 19篇 |
1981年 | 18篇 |
1980年 | 21篇 |
1979年 | 31篇 |
1978年 | 11篇 |
1977年 | 16篇 |
1973年 | 11篇 |
1972年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
目的探讨化浊解毒方治疗溃疡性结肠炎(UC)的治疗作用及机制。方法120例UC患者按照随机数字表法分为观察组、对照组各60例。观察组予中药化浊解毒方口服,每日1剂,早晚2次温服;对照组予美沙拉嗪肠溶片口服,1.0 g/次,3次/d。2组疗程均4周。对比2组治疗前后Geboes指数、结肠镜下黏膜表现、生活质量评分、疾病活动指数及血清炎性因子IL-8、IL-35水平,凝血指标血清FIB水平,统计治疗后1年内复发情况。结果治疗后,观察组Geboes指数、疾病活动指数及血清炎性因子IL-8水平、凝血指标血清FIB水平均较本组治疗前降低,生活质量评分、血清炎性因子IL-35水平升高(P<0.05);且观察组治疗后疾病活动指数及血清炎性因子IL-8水平、凝血指标血清FIB水平均低于对照组,生活质量评分、血清炎性因子IL-35水平均高于对照组(P<0.05)。与对照组相比,治疗组糜烂、溃疡改善不明显(P>0.05),充血水肿、颗粒样变等肠镜表现改善情况均优于对照组(P<0.05)。治疗结束1年观察组复发率为10.64%,对照组为23.53%,2组差异有统计学意义(P<0.05)。结论化浊解毒方能改善UC患者临床症状,修复肠黏膜病理损伤,降低复发率;其机制可能与调节血清炎性因子IL-8、IL-35和凝血因子FIB水平有关。 相似文献
2.
1 建立新型师生关系是实施素质教育的需要
传统教学中,教师是知识的载体,是教学活动的主宰。学生是教师知识传授的对象。课堂上,教师站在讲台上严肃认真地讲解。学生规规矩矩地坐在座位上专心听讲。教师讲的知识点,学生掌握了,就达到教学目的了。教师对学生最为关注的是其学习成绩。学生对教师则敬而远之,甚至关系紧张,很难向教师敞开心扉、畅所欲言。素质教育的核心就是创新教育。而这种师生关系严重阻碍了学生个性的发展和创新意识的培养。 相似文献
3.
4.
目的 了解小儿烧伤的致伤因素和院前急救现状。方法 对十年来两家医院收治的小儿烧伤1403例按年龄、原因、场所以及院前急救进行回顾性分析。结果 小儿烧伤以0~3岁居多(占57.09%);热液烫伤比例大(占70.28%);家庭为烧伤主要场所(占78.12%);院前急救失误普通存在,其中创面处理不当、未建立有效静脉通道和人为原因延误治疗比例较大。结论 小儿烧伤有一定规律,院前急救应加以重视。 相似文献
5.
保留肾单位手术治疗早期小肾癌21例临床分析 总被引:1,自引:0,他引:1
Yao-Jun Xiao Shao-Bin Zheng Wan-Long Tan Tong Chen Huan Qi Zhi-Qiang Shao Yao-Dong Jiang Peng Wu Hui-Jian Zhang 《第一军医大学学报》2005,25(3):357-359
OBJECTIVE: To evaluate the clinical effects of nephron-sparing surgery in patients with early-stage small renal cell carcinoma. METHODS: Nephron-sparing surgery was performed in 21 patients with renal cell carcinoma including 1 with solitary kidney, 3 with unilateral tumor and contralateral renal compromise, and 17 with unilateral tumor and normal contralateral kidney. The diameter of the tumors ranged from 1.5 to 6.0 cm, with a mean of 2.8 cm. The tumor diameter in 17 patients with normal contralateral kidney was less than 4 cm (mean 2.5 cm) and the average diameter in 4 patients with contralateral renal compromise was 4.2 cm. Sixteen cases were in stage T(1), 4 in stage T(2), and 1 in stage T(3). Of the 21 patients, 4 underwent tumor enucleation, 10 polar nephrectomy and 7 wedge resection. RESULTS: All patients were followed up for an average of 40.8 months (7 to 66 months). One patient suffered a right lung and mediastinum metastasis 3 years after the surgery later and 1 with chronic glomerulonephritis required dialysis 27 months after the operation. No surgical complication or local recurrence were found in other patients. CONCLUSION: As a safe and effective therapy for early-stage small renal cell carcinoma, nephron-sparing surgery can be considered as the gold-standard therapy for patients with lesions less than 4 cm in T(1) and T(2) stages of localized unilateral tumor with normal contralateral kidney. 相似文献
6.
7.
Bill J Gurley Ashley Swain Gary W Barone D Keith Williams Philip Breen C Ryan Yates Leslie B Stuart Martha A Hubbard Yudong Tong Sreekhar Cheboyina 《Drug metabolism and disposition》2007,35(2):240-245
Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters may give rise to many herb-drug interactions. Serial plasma concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with goldenseal or kava kava modified P-gp activity in vivo. Twenty healthy volunteers were randomly assigned to receive a standardized goldenseal (3210 mg daily) or kava kava (1227 mg daily) supplement for 14 days, followed by a 30-day washout period. Subjects were also randomized to receive rifampin (600 mg daily, 7 days) and clarithromycin (1000 mg daily, 7 days) as positive controls for P-gp induction and inhibition, respectively. Digoxin (Lanoxin, 0.5 mg) was administered p.o. before and at the end of each supplementation and control period. Serial digoxin plasma concentrations were obtained over 24 h and analyzed by chemiluminescent immunoassay. Comparisons of area under the curve (AUC)((0-3)), AUC((0-24)), C(max,) CL/F, and elimination half-life were used to assess the effects of goldenseal, kava kava, rifampin, and clarithromycin on digoxin pharmacokinetics. Rifampin produced significant reductions (p < 0.01) in AUC((0-3)), AUC((0-24)), CL/F, t(1/2), and C(max), whereas clarithromycin increased these parameters significantly (p < 0.01). With the exception of goldenseal's effect on C(max) (14% increase), no statistically significant effects on digoxin pharmacokinetics were observed following supplementation with either goldenseal or kava kava. When compared with rifampin and clarithromycin, supplementation with these specific formulations of goldenseal or kava kava did not appear to affect digoxin pharmacokinetics, suggesting that these supplements are not potent modulators of P-gp in vivo. 相似文献
8.
便秘是老年糖尿病患者的常见合并症之一.笔者自2006年6月~2007年6月以济川煎为基础方加味治疗老年糖尿病患者合并便秘24例,现报道如下.
…… 相似文献
9.
10.
The influence of sex steroids and the dopaminergic system on the in vivo modulation of prolactin (PRL) mRNA levels was investigated by quantitative in situ hybridization in the male rat anterior pituitary gland. In situ hybridization was performed using a [35S]-labeled cDNA probe encoding PRL. Orchiectomy performed 14 days earlier did not modify PRL mRNA levels. In orchiectomized rats treatment with the dopaminergic agonist bromocriptine for 14 days decreased PRL mRNA levels by 30%, while in intact animals the same treatment did not induce any changes in PRL mRNA levels. Administration of the dopamine D2 receptor antagonist haloperidol in both intact and orchiectomized rats induced a 4-fold increase in mRNA levels. Administration of dihydrotestosterone to orchiectomized animals which had been treated or not with haloperidol or bromocriptine did not modify PRL mRNA levels. In orchiectomized animals administration of 17ß-estradiol (0.25 μg twice daily) for 14 days caused a 4-fold increase in amounts of PRL mRNA. Administration of bromocriptine to 17ß-estradiol-treated animals induced a 15% decrease of PRL mRNA levels compared to those obtained by 17ß-estradiol administered alone. The concomitant administration of 17ß-estradiol and haloperidol resulted in a 50% increase in PRL mRNA levels compared to those measured in animals treated with haloperidol alone. The present results clearly demonstrate that in vivo estrogen as well as dopamine-mediated mechanisms play a regulatory role in PRL mRNA levels in the male rat. 相似文献