全文获取类型
收费全文 | 1618篇 |
免费 | 120篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 114篇 |
妇产科学 | 39篇 |
基础医学 | 170篇 |
口腔科学 | 28篇 |
临床医学 | 122篇 |
内科学 | 382篇 |
皮肤病学 | 12篇 |
神经病学 | 120篇 |
特种医学 | 70篇 |
外科学 | 172篇 |
综合类 | 23篇 |
一般理论 | 2篇 |
预防医学 | 124篇 |
眼科学 | 70篇 |
药学 | 111篇 |
中国医学 | 7篇 |
肿瘤学 | 158篇 |
出版年
2024年 | 2篇 |
2023年 | 16篇 |
2022年 | 28篇 |
2021年 | 67篇 |
2020年 | 57篇 |
2019年 | 69篇 |
2018年 | 73篇 |
2017年 | 45篇 |
2016年 | 59篇 |
2015年 | 55篇 |
2014年 | 93篇 |
2013年 | 91篇 |
2012年 | 159篇 |
2011年 | 157篇 |
2010年 | 85篇 |
2009年 | 64篇 |
2008年 | 103篇 |
2007年 | 107篇 |
2006年 | 108篇 |
2005年 | 74篇 |
2004年 | 51篇 |
2003年 | 45篇 |
2002年 | 34篇 |
2001年 | 12篇 |
2000年 | 27篇 |
1999年 | 4篇 |
1998年 | 10篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 7篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1966年 | 1篇 |
1962年 | 2篇 |
1961年 | 1篇 |
排序方式: 共有1739条查询结果,搜索用时 0 毫秒
1.
A 13-year-old boy who had hemophilia A was reported with pain in the left thigh and hip on walking. He had no history of trauma. Severe hemophilia A is diagnosed with a Factor VIII level of <1 iu/dl. The presumptive diagnosis was that of a spontaneous bleed into the hip joint. Factor VIII mutational analysis revealed a C to G substitution at nucleotide 6683 which results in a cystine change at codon 2194. However, the symptoms persisted and an X-ray demonstrated the presence of an acute on chronic slip of the upper femoral epiphysis. The patient was transferred to the center treating his hemophilia where the hip was pinned in situ under cover with Factor VIII. This case demonstrates the need to be aware of a possible traumatic diagnosis of hip pain in a hemophiliac child with a longstanding history of spontaneous bleeding into joints. 相似文献
2.
3.
Surojit Paul Peter Olausson Deepa V Venkitaramani Irina Ruchkina Timothy D Moran Natalie Tronson Evan Mills Shawn Hakim Michael W Salter Jane R Taylor Paul J Lombroso 《Neuropsychopharmacology》2007,61(9):1049-1061
BACKGROUND: Formation of long-term memories is critically dependent on extracellular-regulated kinase (ERK) signaling. Activation of the ERK pathway by the sequential recruitment of mitogen-activated protein kinases is well understood. In contrast, the proteins that inactivate this pathway are not as well characterized. METHODS: Here we tested the hypothesis that the brain-specific striatal-enriched protein tyrosine phosphatase (STEP) plays a key role in neuroplasticity and fear memory formation by its ability to regulate ERK1/2 activation. RESULTS: STEP co-localizes with the ERKs within neurons of the lateral amygdala. A substrate-trapping STEP protein binds to the ERKs and prevents their nuclear translocation after glutamate stimulation in primary cell cultures. Administration of TAT-STEP into the lateral amygdala (LA) disrupts long-term potentiation (LTP) and selectively disrupts fear memory consolidation. Fear conditioning induces a biphasic activation of ERK1/2 in the LA with an initial activation within 5 minutes of training, a return to baseline levels by 15 minutes, and an increase again at 1 hour. In addition, fear conditioning results in the de novo translation of STEP. Inhibitors of ERK1/2 activation or of protein translation block the synthesis of STEP within the LA after fear conditioning. CONCLUSIONS: Together, these data imply a role for STEP in experience-dependent plasticity and suggest that STEP modulates the activation of ERK1/2 during amygdala-dependent memory formation. The regulation of emotional memory by modulating STEP activity may represent a target for the treatment of psychiatric disorders such as posttraumatic stress disorder (PTSD), panic, and anxiety disorders. 相似文献
4.
C Sundaram Deepa Goel Shantveer G Uppin S Seethajayalakshmi Rupam Borgohain 《Journal of clinical neuroscience》2007,14(9):882-886
BACKGROUND: Intracranial true mycotic aneurysms are uncommon and usually fatal. We report two patients with basilar mycotic aneurysms due to Aspergillus species following surgical interventions. Both patients had subarachnoid hemorrhage and diagnosis was made at autopsy only. The literature regarding etiology, clinical presentation, predisposing conditions and outcome of intracranial true mycotic aneurysms is reviewed from 1990-2005. A high index of clinical suspicion with prompt diagnosis and early treatment may improve patient outcome. 相似文献
5.
The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. 总被引:4,自引:0,他引:4
6.
Mohan V Meera R Premalatha G Deepa R Miranda P Rema M 《Postgraduate medical journal》2000,76(899):569-573
The frequency of proteinuria was assessed in a cohort of 1848 diabetic patients attending a diabetes centre in south India. A total of 127 (6.9%) patients had evidence of macroproteinuria and 49 (2.5%) patients had microproteinuria. Thus overall 9.4% of patients had diabetes related proteinuria. In addition, 70 patients (3.8%) had evidence of proteinuria with no evidence of retinopathy. The frequency of both microproteinuria and macroproteinuria increased linearly with duration of diabetes. Multiple logistic regression analysis showed that duration of diabetes, serum creatinine, and glycated haemoglobin were risk factors for macroproteinuria. 相似文献
7.
8.
Sahithya Bhaskaran Jeyaseeli Flora Vijayalakshmi Perumalsamy Deepa Chitra Durairaj 《Indian journal of ophthalmology》2022,70(4):1307
Purpose:To understand/assess ocular and functional vision impairment in children with multiple disabilities with a functional vision assessment battery in addition to standard ophthalmic examinations in an outreach setting.Methods:Seven schools for children with special needs, 243 children in total, were screened for ocular disorders and functional vision impairment through school camps.Results:Among them, 37% had refractive errors needing spectacle correction. With standard ocular testing methods, the visual impairment was around 32%, but when functional vision was assessed, the functional vision impairment amounted to 70% in these children. The presence of functional vision impairment was found to be independent of the associated disability. Assessment of visual capacities such as visual closure, saccade pursuits, optic ataxia, and developmental milestones early on can help in suspecting the presence of CVIConclusion:Children with multiple disabilities are more at risk of functional vision impairment, which significantly impairs their ability to function in daily life. A complete functional vision assessment becomes essential to plan early intervention for these children. The significant proportion of vision impairment and functional vision loss in our study indicates the need for coordinated structured programs to address vision-related problems in children with multiple disabilities. 相似文献
9.
10.
Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study 下载免费PDF全文
Bhojwani D Kang H Moskowitz NP Min DJ Lee H Potter JW Davidson G Willman CL Borowitz MJ Belitskaya-Levy I Hunger SP Raetz EA Carroll WL 《Blood》2006,108(2):711-717
Outcome for children with childhood acute lymphoblastic leukemia (ALL) who relapse is poor. To gain insight into the mechanisms of relapse, we analyzed gene-expression profiles in 35 matched diagnosis/relapse pairs as well as 60 uniformly treated children at relapse using the Affymetrix platform. Matched-pair analyses revealed significant differences in the expression of genes involved in cell-cycle regulation, DNA repair, and apoptosis between diagnostic and early-relapse samples. Many of these pathways have been implicated in tumorigenesis previously and are attractive targets for intervention strategies. In contrast, no common pattern of changes was observed among late-relapse pairs. Early-relapse samples were more likely to be similar to their respective diagnostic sample while we noted greater divergence in gene-expression patterns among late-relapse pairs. Comparison of expression profiles of early- versus late-relapse samples indicated that early-relapse clones were characterized by overexpression of biologic pathways associated with cell-cycle regulation. These results suggest that early-relapse results from the emergence of a related clone, characterized by the up-regulation of genes mediating cell proliferation. In contrast, late relapse appears to be mediated by diverse pathways. 相似文献