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目的:分析并总结我院收治的自身免疫性胰腺炎( AIP)临床特征及诊治经验。方法回顾性分析2009年至2013年我院收治的13例AIP的临床资料。结果13例AIP中,中位年龄48岁,临床表现主要为上腹疼痛不适,梗阻性黄疸及体重下降。胰腺弥漫性增大及局限性增大各6例,胰体尾假性囊肿及胰腺结石各1例,胰管扩张4例。胰腺外器官受累9例(胆管病变8例、胆囊病变7例、腹膜后纤维化1例、腹腔淋巴结肿大6例、脾静脉变细4例、干燥综合征及溃疡性结肠炎各1例)。7例行血免疫标志物检查,IgG升高5例,类风湿因子( RF)及抗核抗体( ANA)升高各3例。8例被误诊而行手术治疗。经激素治疗后,患者预后良好。结论 AIP是一种少见的自身免疫性疾病,无特异临床表现,易与胰腺癌及胆管癌混淆,误诊率高。必须充分认识和重视AlP的诊治,避免因误诊而行不必要的手术治疗。 相似文献
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AH Al-Mahdi LE Al-Khurrhi GZ Atto A Dhaher 《The Journal of craniofacial surgery》2012,23(5):1563-1565
ABSTRACT: Hypoglossal schwannomas usually develop in the intracranial portion of the brain. Incidence of hypoglossal schwannomas of the submandibular region is extremely rare. A 27-year-old patient presented to us with hypoglossal schwannoma of the tongue and the submandibular region. The tumor was excised intraorally combined with submandibular approach. Histopathologic examination revealed a plexiform schwannoma (a rare variant). 相似文献
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Camillo Porta Riccardo Centurioni Luigi Gugliotta Enrico Bobbio-Phllavicini Atto Billio 《American journal of hematology》1996,52(3):215-216
We examined the retrospective case series of the Itallan Cooperative Group to determine the incidence of relapes in TTP patients. Of 60 patients who have crossed the 10-year threshold from the first episode, Only 9 (15%) relapsed during that period, a figure far lower than that reported recently. Such difference is hardly explainable on the basis of our current knowledge of the biological behaviour of TTP. Furthermore, we unsuccessfully analyzed the treatment performed in each of our relapsed patients, in search of some element that could retrospectively predict the subsequent relapse 相似文献
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Pier Luigi Zinzani Monia Marchetti Atto Billio Giovanni Barosi Angelo Michele Carella Mario Lazzarino Maurizio Martelli Alessandro Rambaldi Luigi Rigacci Corrado Tarella Umberto Vitolo Sante Tura 《American journal of hematology》2013,88(3):185-192
By using the GRADE system, we updated the guidelines for management of follicular cell lymphoma issued in 2006 from SIE, SIES, and GITMO group. We confirmed our recommendation to frontline chemoimmunotherapy in patients with Stage III–IV disease and/or high tumor burden. Maintenance rituximab was also recommended in responding patients. In patients relapsing after an interval longer than 12 months from frontline therapy, we recommended chemoimmunotherapy with non cross‐resistant regimens followed by rituximab maintenance. High dose chemotherapy followed by hematopoietic stem cell transplant was recommended for young fit patients who achieve a response after salvage chemoimmunotherapy. Am. J. Hematol. 88:185–192, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
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Michael Mian Norbert Pescosta Stefania Badiali Paola Cristina Cappelletto Luigi Marcheselli Stefano Luminari Francesca Patriarca Renato Zambello Anna Pascarella Giuseppe Tagariello Alessandra Marabese Patrizia Mondello Atto Billio Sergio Cortelazzo 《British journal of haematology》2019,185(5):944-947
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Michele Merli Isacco Ferrarini Francesco Merli Alessandro Busca Roberto Mina Brunangelo Falini Riccardo Bruna Roberto Cairoli Monia Marchetti Alessandra Romano Michele Cavo Luca Arcaini Livio Trentin Chiara Cattaneo Enrico Derenzini Nicola Stefano Fracchiolla Francesco Marchesi Annamaria Scattolin Atto Billio Monica Bocchia Massimo Massaia Carlo Gambacorti-Passerini Francesca Romana Mauro Massimo Gentile Sara Mohamed Matteo Giovanni Della Porta Elisa Coviello Daniela Cilloni Giuseppe Visani Augusto Bramante Federici Maria Chiara Tisi Laura Cudillo Sara Galimberti Filippo Gherlinzoni Livio Pagano Anna Guidetti Lorenza Bertù Paolo Corradini Francesco Passamonti Carlo Visco 《Hematological oncology》2023,41(1):128-138
COVID-19, the disease caused by SARS-CoV-2, is still afflicting thousands of people across the globe. Few studies on COVID-19 in chronic lymphocytic leukemia (CLL) are available. Here, we analyzed data from the CLL cohort of the Italian Hematology Alliance on COVID-19 (NCT04352556), which included 256 CLL patients enrolled between 25 February 2020 and 1 February 2021. Median age was 70 years (range 38–94) with male preponderance (60.1%). Approximately half of patients (n = 127) had received at least one line of therapy for CLL, including 108 (83.7%) who were on active treatment at the time of COVID-19 or received their last therapy within 12 months. Most patients (230/256, 89.9%) were symptomatic at COVID-19 diagnosis and the majority required hospitalization (n = 176). Overall, after a median follow-up of 42 days (IQR 24–96), case fatality rate was 30.1%, and it was 37.5% and 24.4% in the first (25 February 2020–22 June 2020) and second wave (23 June 2020–1 February 2021), respectively (p = 0.03). At multivariate analysis, male sex (HR 1.82, 95% CI 1.03–3.24, p = 0.04), age over than 70 years (HR 2.23, 95% CI 1.23–4.05, p = 0.01), any treatment for CLL given in the last 12 months (HR 1.72, 95% CI 1.04–2.84, p = 0.04) and COVID-19 severity (severe: HR 5.66, 95% CI 2.62–12.33, p < 0.0001; critical: HR 15.99, 95% CI 6.93–36.90, p < 0.0001) were independently associated with poor survival. In summary, we report a dismal COVID-related outcome in a significant fraction of CLL patients, that can be nicely predicted by clinical parameters. 相似文献
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Antonio Cuneo Monia Marchetti Giovanni Barosi Atto Billio Maura Brugiatelli Stefania Ciolli Luca Laurenti Francesca Romana Mauro Stefano Molica Marco Montillo Pierluigi Zinzani Sante Tura 《Leukemia research》2014
By using the GRADE system we produced the following recommendations for the use of bendamustine in the first-line treatment of CLL: (1) bendamustine with rituximab is recommended in elderly fit patients potentially eligible to FCR; (2) Bendamustine alone is recommended in patients who are candidate to chlorambucil alone; (3) Rituximab–bendamustine is recommended in patients not eligible to FCR, but suitable to receive rituximab. Consensus-based recommendations addressed evidence-orphan issues concerning the use of bendamustine in genetically-defined high-risk patients and the appropriate dose of bendamustine as single agent or in association with rituximab. 相似文献
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Alemtuzumab (Campath-1H) and CHOP chemotherapy as first-line treatment of peripheral T-cell lymphoma: results of a GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) prospective multicenter trial 总被引:5,自引:0,他引:5 下载免费PDF全文
Gallamini A Zaja F Patti C Billio A Specchia MR Tucci A Levis A Manna A Secondo V Rigacci L Pinto A Iannitto E Zoli V Torchio P Pileri S Tarella C 《Blood》2007,110(7):2316-2323
To evaluate in a prospective multicenter trial the feasibility and clinical efficacy of the combination of alemtuzumab (Campath-1H) with the cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) regimen (CHOP-C) as the primary treatment for patients with peripheral T-cell lymphoma (PTCL), between January 2003 and December 2005, 24 consecutive patients with PTCL entered the study and received 8 CHOP courses. Alemtuzumab was added at 30 mg subcutaneously at day -1 initially to the first 4 courses (4 patients), and then to all 8 courses (20 patients). Complete remission (CR) was achieved in 17 (71%) patients, 1 had partial remission, and 6 had stable/progressive disease. At a median follow-up of 16 months (range, 5-42 months), 14 patients were alive, 9 had died from progressive disease, and 1 had died from pneumonia at day +198 while in CR. So far, 13 are disease-free, with an overall median duration of response of 11 months. The most frequent side effects were grade 4 neutropenia and cytomegalovirus (CMV) reactivation. Major infections were Jacob-Creutzfeldt (J-C) virus reactivation, pulmonary invasive aspergillosis, Staphylococcus sepsis, and pneumonia. This study shows that CHOP-C: (1) is a feasible chemoimmunotherapy regimen; (2) is effective in PTCL with a high rate of CR achievement; and (3) is associated with mostly manageable infectious complications. This clinical trial was registered with the Osservatorio Nazionale sulla Sperimentazione cinica as ID no. 141202. 相似文献