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OBJECTIVE: To study the effect of 5-fluorocytosine (5-FC) as prodrug in the treatment of Wilms' tumor xenografts transduced with cytosine deaminase (CD) gene. METHODS: An in vivo model of a poorly differentiated Wilms' tumor transplanted in nude mice was established. Expression adenoviral-vector of CD gene (Ad/CMV-CD) or lac gene (Ad/CMV-lac) was transduced to the tumor xenografts by intratumoral injections. Expression of the transduced genes were confirmed by RT-PCR. Mice with Wilms' tumor xenograft were treated with 5-FC (500 mg.kg-1.d-1 x 10 d). Tumor growth was monitored. RESULTS: The growth of tumor xenografts transduced with lac gene grew as quick as the untransduced ones. In contrast, the growth of the tumor xenografts transduced with CD gene was significantly inhibited as compared to untransduced and lac gene transduced xenografts. The average rate of inhibition was 65% according to the tumor weight at 8 wk. Cell necrosis was observed in the CD gene transduced tumors. CONCLUSION: Intratumoral cytosine deaminase gene transduction followed by systemic 5-fluorocytosine is effective in the treatment of Wilms' tumor. 相似文献
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本研究回顾性分析1959年一1994年间收治的神经母细胞瘤病例148例,均有典型的临床症状和B超、CT、X线表现、VMA值升高或骨髓涂片异常,其中IOg例经手术探查,病理确诊。研究参照Wilson方法进行临床资料分析和Evans临床分期。98例获术后1年一18年的随访,至今存活22例。生存曲线 相似文献
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末端游离可摘局部义齿是常见的牙列缺损修复类型,此类义齿的设计多采用基托下组织与基牙共同支持方式,其特点是义齿的负荷由两种组织共同承担:基牙承受相对不活动的支持,和牙槽嵴及其上覆盖的软组织所提供的支持。由于两种支持组织的压缩系数各不相同而造成承受力分布不均,因此在修复设 相似文献
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过去口腔科检查颌骨及其周围结构的常用技术为常规X线摄片,近年来随着种植牙的发展,口腔科医师发现单靠常规X线片作为术前检查有很大的局限性,目前已有牙CT(dental CT,dentascan)重建软件并逐步应用于临床,这一新技术已经开始逐步取代常规X线摄片。牙CT成像软件是一种特殊的检查技术和软件,它通过横断面CT薄层扫描,可重建获得颌-口腔全景图像和各方位断层图像,图像清晰直观,已被成功用于种植牙术前测量、口腔炎症、肿瘤和口腔上颌窦瘘等多种疾病的诊断。 相似文献
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研究了甲基黄酮丙醇胺酰胺盐酸盐(SIPI-644)对电刺激家兔左心室致颤阈值(VFT)的影响,并在等毒剂量下同甲基黄酮丙醇胺盐酸盐(SIPI-549)、胺碘酮盐酸盐(Ami)、利多卡因(Lid)和奎尼丁(Qui)等药物进行了比较。结果表明,SIPI-644在iv1.8~14.4mg/kg(0.0125~0.1LD_(50))剂量范围内包括对正常心脏、急性缺血心脏、和阻滞植物神经系统的缺血心脏均能明显提高VFT值,且对正常心脏其作用与剂量呈线性相关关系。在0.1LD_(50)剂量时,SIPI-644使VFT提高的程度显著高于各对照组,其急性毒性明显低于Lid、Qui和SIPI-549,同Ami近似。 相似文献
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目的探讨腹膜后淋巴结清扫术以及AFP和睾丸肿瘤治疗中的价值方法43例涉猎 睾丸肿瘤中有27例腹膜后淋巴结清扫术。16例AFP升高,随访32例存活29例,其中淋巴结清扫16例,未清扫13例,存活病例术前AFP阳性8例。结果腹膜后地清扫组的存活率与未清扫组无显著差异,术前AFP阳性的存活率与阴性者亦无显著差异。结论不应将腹膜后淋巴结清扫术作为小儿睾丸肿瘤的常规治疗;术前AFP升高与预后无相关关系。 相似文献