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Ziya Cetinkaya Kazim Esen Ibrahim Hanefi Ozercan Bilal Ustundag Refik Ayten Erhan Aygen 《World journal of emergency surgery : WJES》2006,1(1):37
Background
Ischemia is the most important factor compromises wound healing in colonic anastomosis. Mesenteric vessels are ligated at first while performing colonic resection and following anastomosis. Therefore blood supply of the related segments of colon temporarily interrupted and ischemia can easily occur. This study was carried out to explore whether Bosentan, an endothelin-receptor antagonist, can eliminate vasoconstruction, increase blood flow in the splanchnic area and anastomotic region and therefore possibly facilitate wound healing and prevent intra-abdominal adhesion formation. 相似文献4.
Uterine rupture during labor, when it is in the immediate vicinity of the cervix, frequently extends transversely or obliquely. Usually the tear is longitudinal when it occurs in the portion of the uterus adjacent to the broad ligament. We report an unusual case of uterine rupture through posterior vaginal fornix of the posterior lower uterine segment. 相似文献
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Faruk İldan Erdal Çetinalp Hüseyin Bagdatoglu Bülent Boyar Ziya Uzuneyüpoglu Aşkin Karadayi 《Neurosurgical review》1995,18(2):135-138
The authors describe a case of giant fusiform aneurysm of the basilar artery presenting with ischemic symptoms. Angiography and CT revealed vertebro-basilar fusiform aneurysmal dilatation. Fusiform vertebro-basilar ancurysm is associated with various complications particularly brain stem infarction. Similar lesions in the literature are reviewed and the relationship between this clinical entity and cerebral ischemia, particularly brainstem infarction are discussed. 相似文献
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Inhibition of in vivo tumorigenicity and invasiveness of a human glioblastoma cell line transfected with antisense uPAR vectors 总被引:1,自引:0,他引:1
Yoshinori Go Shravan K. Chintala Sanjeeva Mohanam Ziya Gokaslan Boyapati Venkaiah Rolf Bjerkvig Kazunari Oka Garth L. Nicolson Raymond Sawaya Jasti S. Rao 《Clinical & experimental metastasis》1997,15(4):440-446
Our previous studies showed that glioblastomas express increased urokinase-type plasminogen activator receptors (uPARs) in comparison to low-grade gliomas (Yamamoto et al., Cancer Res., 54, 5016-5020, 1994). To explore whether downregulation of uPAR inhibits tumor formation and invasiveness, a human glioblastoma cell line was transfected with a cDNA construct corresponding to 300 bp of the human uPAR's 5¢ end in an antisense orientation, resulting in a reduced number of uPA receptors. Co-culture studies with tumor spheroids and fetal rat brain aggregates showed that antisense SNB19-AS1 cells expressing reduced uPAR failed to invade fetal rat brain aggregates. Intracerebral injection of SNB19-AS1 stable transfectants failed to form tumors and were negative for uPAR expression in nude mice. Thus uPAR appears in this model to be essential for tumorigenicity and invasion of glioblastomas in vivo. 相似文献
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Ihsan H. Ciftci Umit Dundar Zafer Cetinkaya Mustafa Kulac Nilay Kiyildi Aycan Turel Deniz Evcik Vural Kavuncu 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2007,52(1):70-73
The objective of this study was to investigate the incidence and density of Demodex folliculorum in the patients with rheumatoid arthritis (RA). Forty-one patients with RA and twenty-seven age and sex matched healthy controls
were enrolled in this study. Disease Activity Score (DAS 28) was used for the assessment of disease activity. Out of 41 patients,
33 were females and 8 males. The mean disease duration was 10.9 ± 8.2 years. The mean DAS 28 was 3.8 ± 1.2. No statistically
significant differences in the incidence and density of Demodex mites were found between patients with RA and controls. Although immunosuppression is thought to be a risk factor for the
D. folliculorum infestation no such correlations could be found in the 41 immunosuppressed patients with RA, therefore, further studies with
larger groups are needed. 相似文献
9.
Aydan Kansu Nurten Girgin Cihan YurdaydN HÜLya Cetinkaya ÖZden Uzunalimoglu 《Pediatrics international》1998,40(6):612-615
Chronic pancreatitis is a rare disease in children and is usually secondary to underlying diseases such as hereditary pancreatitis, cystic fibrosis, hyperlipidemia, prolonged malnutrition, gallstones or anomalies of the biliary-pancreatic duct system. Hereditary pancreatitis is a common cause of chronic pancreatitis in children but is often unrecognized until months or years later. We report here a family with hereditary pancreatitis in which four members are affected. 相似文献
10.
Bahram Mohammadi Klaus Krampfl Cener Cetinkaya Heiner Wolfes Reinhard Dengler Johannes Bufler 《Pharmacological research》2005,51(6):587-592
Glycine receptor channels are pentameric ligand-gated ion channels that respond to the application of inhibitory neurotransmitters by opening of a chloride-selective central pore. Topiramate (TPM) is a broad-spectrum antiepileptic drug used as add-on or monotherapy for focal seizures. In the present study the interaction of TPM with glycine receptor channels was studied on outside-out patches from HEK293 cells expressing alpha1beta glycine receptor channels. The patch clamp techniques combined with ultra fast solution exchange enabled us to investigate the kinetics of receptor channels in presence of TPM. Our study showed no agonistic or potentiating effect for TPM on glycine receptor channels. However, in presence of 1 mM glycine + 1 mM TPM, the desensitization got faster and the peak current amplitude decreased. After the end of glycine + TPM pulses, off-currents occurred, suggestive for a specific channel block mechanism. 相似文献