云南药用植物根结线虫病调查

1994－1997年对云南省20余县市,52种药用植物根结线虫病情况进行了调查,共采集185份标本,其中76份标本鉴定有4种根结线虫：南方根结线虫、爪哇根结线虫、花生根结线虫和北方根结线虫,并引起21种药用植物的根结线虫病。文章概述了21种药用植物根结线虫病的危害程度及分布。     

高要和吴川产藿香对消化系统的作用比较

本实验比较了高要与吴川产霍香的3种提取物(水提物、去油水提物、挥发油混悬液)对消化系统的作用。结果表明两产地藿香均有解除胃肠道痉挚和促进消化的作用,总体效应高要产藿香略强于吴川产藿香。     

AQP3、7、9在人下颌下腺的免疫组化定位

采用免疫组化ABC法检测源自10例颈淋巴清扫患者的正常下颌下腺组织AQP3、7、9蛋白的表达。AQP3在浆液性腺泡和黏液性腺泡细胞均有表达,分布于腺泡细胞的基底膜和侧膜,在浆液性腺泡细胞中的表达明显高于黏液性腺泡细胞,导管系统未见AQP3表达;AQP7在极少数肌上皮细胞有表达;AQP9在部分浆液性腺泡腔、混合性腺泡腔以及部分闰管管腔和浆液性半月体上有表达。     

The role of urine IgG in the progression of IgA nephropathy with a high proportion of global glomerulosclerosis

International Urology and Nephrology - IgA nephropathy (IgAN), the most common glomerulonephritis in the world, is an important cause of end-stage renal disease (ESRD). It is necessary to explore...     

Successful treatment of hemophagocytic syndrome in a patient with T cell lymphoma,EBV infection,and bone marrow necrosis: A case report

Rationale:Hemophagocytic syndrome (HPS) is associated with a high mortality rate, and Epstein–Barr virus infection and hematological malignancies, especially T/natural killer cell lymphomas, are the most common causes; however, due to the complexity of clinical manifestations, the diagnosis is usually delayed. There are few reports of lymphoma-associated HPS (LAPS) in combination with bone marrow necrosis, and there is still no standard treatment for LAPS.Patient concerns:A 64-year-old man developed a fever, mild jaundice, fatigue, and bone pain. Positron emission tomography and bone marrow biopsy with immunohistochemistry were performed.Diagnosis:Imaging analysis and bone marrow examinations were compatible with HPS, T-cell lymphoma, and bone marrow necrosis.Interventions:The patient received combination therapy of rituximab and Cyclophosphamide, epirubicin, vincristine, glucocorticoid, etoposide.Outcomes:The patient achieved complete remission and a disease-free survival of 52 months.Lessons:HPS and its potential diseases should be diagnosed and treated as soon as possible. Clinicians should be aware of the presence of lymphoma in patients with HPS. Rituximab plays an important role in the prognosis of HPS, particularly Epstein–Barr virus positivity. Cyclophosphamide, epirubicin, vincristine, glucocorticoid remains an effective regimen for the treatment of T-cell LAPS. This study provides a better understanding of the diagnosis and treatment of LAPS.     

脱氧胆酸诱导大肠癌发生的研究

胆汁酸中的脱氧胆酸可以促进肿瘤的形成,脱氧胆酸诱发的细胞凋亡在大肠癌的发生中起着重要作用。提高粪便中胆汁酸含量可增加患大肠癌的风险,表明脱氧胆酸可以促进大肠癌的发生、发展。脱氧胆酸作为一种促癌因子在大肠癌的发生中起很大作用,同时通过多种机制诱发大肠癌的发生。     

Muir-Torre综合征的研究进展

Muir-Torre综合征(MTS)是一种罕见的遗传性疾病,本病的发生与DNA错配修复的种系突变相关。临床表现为皮肤肿瘤(以皮脂腺腺瘤多见)和内脏恶性肿瘤(以胃肠道恶性肿瘤多见)。免疫组化和基因检测是本病的常用诊断方法。确诊后需要进行手术治疗及化学治疗。     

高要产广藿香挥发油成分分析

应用气相色谱-质谱联用技术对高要产广藿香茎和叶中挥发油成分进行了分析,从茎油中分离出107个色谱峰,鉴定了52个化合物,占总量的78.83％;从叶油中分离出50个色谱峰,鉴定了36个化合物,占总量的96.95％。茎和叶油中主要含广藿香酮(分别为30.99％和21.31％)、广藿香醇(10.26％和37.53％)反式-丁香烯(4.92％和6.75％)、α-愈创木稀(2.27％和6.18％)、反式,反式-法呢醛(2.04％和1.40％)、α-广藿香烯(1.13％和2.71％)、刺蕊草烯(1.56％和1.99％)等。茎与叶挥发油中亦存在一些差异:茎中有27个成分是叶中没有或含量极微而未能检出,叶中亦有11个成分是茎中不具有的。     

开展专科临床药学的工作体会

目的探讨临床药师在临床治疗中的作用。方法通过临床药师对病人实施药学服务实践,开展分析评价并总结经验。结果药师下临床可以降低医疗成本,减少不良反应,降低医疗风险,提高药物治疗水平。结论临床药学是一门实践性学科,深入临床,以病人为中心是开展临床药学的必经之路。     

Epidemiological survey of Angiostrongylus cantonensis in the west-central region of Guangdong Province, China

The study was to understand the Angiostrongylus cantonensis infectious situation of rodent definitive host, snail intermediate host, and local residents in the west-central region of Guangdong Province in China. The snails Achatina fulica and Pomacea canaliculata collected from the survey place were digested with artificial gastric juice, and the third-stage larvae of A. cantonensis in the snails were examined under microscope. The heart and lung of rats captured from the survey place were taken to check the adult of A. cantonensis. The questionnaire surveys related to the infection of A. cantonensis were taken in local residents randomly selected, and the IgG antibody against A. cantonensis was tested in those residents with enzyme-linked immunosorbent assay (ELISA). A total of 1,391 rats including eight kinds of rats, such as Rattus norvegicus, Rattus flavipectus, Bandicota indica, Rattus sladeni, Mus musculus, Rattus rattoides, Suncus Murinus, and Rattus confucianus, were examined and 132 of them were infected by A. cantonensis, with an average infection rate of 9.49% and a mean intensity of A. cantonensis in infected rats was 9.39. A total of 3,184 snails A. fulica and 3,723 snails P. canaliculata were detected. The average infection rates of them were 25.03% (797/3,184) and 6.50% (242/3,723), respectively. There were 180 positive samples of IgG antibody against A. cantonensis in 1,800 serum samples of the residents, with a positive rate of 10.00%. The west-central region of Guangdong Province is the natural focus of A. cantonensis. In comparison with the investigation results in other regions of China, the infection rate of rat definitive host is at the middle level; in the intermediate host, the infection rate of snail A. fulica is above the middle level, and the infection rate of snail Pomacea canaliculata is below the middle level. Some local residents had already been infected by A. cantonensis or at the risk of being infected.