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排序方式: 共有518条查询结果,搜索用时 15 毫秒
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Tadaaki Yokota Yoshimi Yamashita Yoshiko Okuzono Mutsuo Takahashi Shigeyoshi Fujihara Shin'ichiro Akizuki Tokuhiro Ishihara Fumiya Uchino Takako Iwata 《Pathology international》1984,34(3):663-668
A case of malignant cystosarcoma phyllodes of the prostate is reported in a 45-year-old male. This tumor was composed of benign columnar or squamous cystic folds and sarcomatous stroma including rhabdomyomatous elements. The prostatic origin of the tumor was clearly proved by the unlabeled immunoperoxidase method. ACTA PATHOL. JPN. 34: 663–668, 1984. 相似文献
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Hitoshi Nishimura Masashi Emoto Kenji Hiromatsu Shunsuke Yamamoto Keiko Matsuura Hiroshi Gomi Toshio Ikeda Shigeyoshi Itohara Yasunobu Yoshikai 《European journal of immunology》1995,25(5):1465-1468
The secretion of tumor necrosis factor (TNF)-α from macrophages is regulated by both priming and triggering signals. We found that macrophages from mice lacking γδ T cells [T cell receptor (TCR) δ?/- mice], which lack the gene encoding the δ chain, produced only small amounts of TNF-α in response to lipopolysaccharide (LPS) and showed a reduced level of expression of CD14. Pre-incubation of macrophages from TCR δ-/- mice with γδ T cells from their TCR δ+/- littermates restored their capacity to produce TNF-α in response to LPS. The priming activity of γδ T cells was in part inhibited by neutralizing anti-interferon (IFN)-γ monoclonal antibodies. Collectively, these results suggest that γδ T cells play a role in priming macrophages to a steady state of activation via IFN-γ secretion, which allows them to produce TNF-α when exposed to LPS. 相似文献
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We investigated the type of T cell response involved in Meth A tumor rejection in primary immune and hyperimmune syngeneic mice. It was found that a CD4+ T cell-mediated delayed-type hypersensitivity (DTH) response activating non-specific killer cells such as macrophages, NK and LAK cells, without a specific CD8+ cytotoxic T lymphocyte (CTL) response, was the major immune response leading to Meth A tumor rejection in primary immune mice. In contrast, the specific CD8+ CTL response was the major response leading to the tumor rejection, in addition to CD4+ T cell-mediated DTH response, in hyperimmune mice. Analysis of CD4+ T cell clones established from primary immune and hyperimmune spleen cells indicated that a CD4+ T cell clone (C9) of primary immune mice (although only one clone was established) was of Th1 type, and induced cytotoxicity in accessory cells by classic DTH in vitro. Eight CD4+ T cell clones were established from hyperimmune spleen cells. Six out of the eight clones were of the Th2 type and two were Th0-like. However, no Th1-type CD4+ T cell clone was established from hyperimmune spleen cells. All of these CD4+ T cell clones, even the Th2-type clones, were capable of inducing cytotoxicity in vitro in T cell-depleted accessory cells, as in an in vitro DTH response. We postulate on the basis of these results that the T cell response leading to Meth A tumor rejection in vivo sequentially changed from a CD4+ T cell-mediated classic DTH response to a CD8+ CTL response, in addition to a cellular response mediated probably by Th2-type cells, during the process of repeated immunization. 相似文献
6.
Hidenori Kanazawa Kenichi Utano Shigeyoshi Kijima Takahiro Sasaki Yasuyuki Miyakura Hisanaga Horie Yoshikazu Nakamura Hideharu Sugimoto 《Japanese journal of radiology》2014,32(5):274-281
Objectives
The purpose of this study was to compare the degree of colorectal distention between manual insufflation using room air and automatic insufflation using carbon dioxide for computed tomography colonography performed as a preoperative examination for patients with colon cancer.Materials and methods
Participants comprised 200 patients who underwent computed tomography colonography immediately after colonoscopy from October 2011–2012. The first 100 patients were examined using manual insufflation, and the remaining 100 patients were examined using automated insufflation. Two radiologists independently assessed colorectal distention using a 4-point scale in six segments: cecum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. Mean scores of the two radiologists were used to analyze whether any differences existed between techniques in terms of the degree of distention per segment.Results
Mean distention values for the colonic lumen were better using the automated technique than with the manual technique in both positions (p < 0.05). In segments, distention was significantly better using the automated technique than using the manual technique in the sigmoid and descending colon for prone patients, and in all segments for supine patients.Conclusions
Automated carbon dioxide insufflation offered significantly improved colorectal distention scores compared to manual room air insufflation. 相似文献7.
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Haemophagocytic lymphohistiocytosis, interferon-gamma-naemia and Epstein-Barr virus involvement 总被引:7,自引:0,他引:7
Shinsaku Imashuku Shigeyoshi Hibi Fumihiro Fujiwara Satoshi Ikushima Shinjiro Todo 《British journal of haematology》1994,88(3):656-658
Summary. To clarify the correlation between Epstein-Barr virus (EBV) involvement and hypercytokinaemia in haemophagocytic lymphohistiocytosis (HLH), we analysed serum interferon-gamma levels and EBV-DNA in biological specimens obtained from 25 HLH cases (23 children and two adults). We found that HLH patients showed a wide range of serum IFN-gamma levels from 0.2 to 1300 U/ml, with a median 126U/ml for EBV-DNA-positive (n = 9) and 4.5 U/ml for EBV-DNA-negative (n = 16) groups. The latter group could be classified further into a group with hyper-IFN-gamma-naemia (> 4.5 U/ml) (n = 8) and a group without hyper-IFN-gamma-naemia (n = 8). The survival of the hyper-IFN-gamma-naemic cases was significantly poorer than non-hyper-IFN-gamma-naemic cases. We conclude that EBV is probably involved in one third of the HLH cases, all of whom show hyper-IFN-gamma-naemia, and in the half of the HLH cases with hyper-IFN-gamma-naemia who have a rapidly fatal outcome. 相似文献
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The reaction of O2 with a Ru13@Pt42 core–shell particle consisting of a Ru13 core and a Pt42 shell was theoretically investigated in comparison with Pt55. The O2 binding energy with Pt55 is larger than that with Ru13@Pt42, and O–O bond cleavage occurs more easily with a smaller activation barrier (Ea) on Pt55 than on Ru13@Pt42. Protonation to the Pt42 surface followed by one-electron reduction leads to the formation of an H atom on the surface with considerable exothermicity. The H atom reacts with the adsorbed O2 molecule to afford an OOH species with a larger Ea value on Pt55 than on Ru13@Pt42. An OOH species is also formed by protonation of the adsorbed O2 molecule, followed by one-electron reduction, with a large exothermicity in both Pt55 and Ru13@Pt42. O–OH bond cleavage occurs with a smaller Ea on Pt55 than on Ru13@Pt42. The lower reactivity of Ru13@Pt42 than that of Pt55 on the O–O and O–OH bond cleavages arises from the presence of lower energy in the d-valence band-top and d-band center in Ru13@Pt42 than in Pt55. The smaller Ea for OOH formation on Ru13@Pt42 than on Pt55 arises from weaker Ru13@Pt42–O2 and Ru13@Pt42–H bonds than the Pt55–O2 and Pt55–H bonds, respectively. The low-energy d-valence band-top is responsible for the weak Ru13@Pt42–O and Ru13@Pt42–OH bonds. Thus, the low-energy d-valence band-top and d-band center are important properties of the Ru13@Pt42 particle.In this theoretical study by DFT computations, characteristic features of the Ru13@Pt42 core–shell particle in O2 activation are clearly discussed in comparison with Pt55. 相似文献