全文获取类型
收费全文 | 2048篇 |
免费 | 163篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 46篇 |
妇产科学 | 19篇 |
基础医学 | 306篇 |
口腔科学 | 32篇 |
临床医学 | 148篇 |
内科学 | 350篇 |
皮肤病学 | 42篇 |
神经病学 | 43篇 |
特种医学 | 136篇 |
外科学 | 347篇 |
综合类 | 294篇 |
一般理论 | 2篇 |
预防医学 | 72篇 |
眼科学 | 33篇 |
药学 | 129篇 |
中国医学 | 1篇 |
肿瘤学 | 199篇 |
出版年
2023年 | 14篇 |
2022年 | 21篇 |
2021年 | 60篇 |
2020年 | 31篇 |
2019年 | 25篇 |
2018年 | 54篇 |
2017年 | 37篇 |
2016年 | 42篇 |
2015年 | 58篇 |
2014年 | 59篇 |
2013年 | 81篇 |
2012年 | 114篇 |
2011年 | 94篇 |
2010年 | 95篇 |
2009年 | 84篇 |
2008年 | 102篇 |
2007年 | 99篇 |
2006年 | 104篇 |
2005年 | 101篇 |
2004年 | 100篇 |
2003年 | 63篇 |
2002年 | 70篇 |
2001年 | 58篇 |
2000年 | 63篇 |
1999年 | 49篇 |
1998年 | 51篇 |
1997年 | 60篇 |
1996年 | 61篇 |
1995年 | 40篇 |
1994年 | 35篇 |
1993年 | 20篇 |
1992年 | 18篇 |
1991年 | 17篇 |
1990年 | 13篇 |
1989年 | 12篇 |
1988年 | 22篇 |
1987年 | 19篇 |
1986年 | 17篇 |
1985年 | 22篇 |
1984年 | 16篇 |
1983年 | 18篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 7篇 |
1979年 | 10篇 |
1978年 | 8篇 |
1977年 | 12篇 |
1975年 | 6篇 |
1972年 | 6篇 |
1971年 | 8篇 |
排序方式: 共有2223条查询结果,搜索用时 15 毫秒
1.
2.
3.
Sonoelasticity imaging of prostate cancer: in vitro results 总被引:2,自引:0,他引:2
4.
5.
Guntur E Luis Chee-Khuen Yong Deepak A Singh S Sengupta David SK Choon 《Journal of orthopaedic surgery and research》2007,2(1):22-10
Background
Acromioclavicular injuries are common in sports medicine. Surgical intervention is generally advocated for chronic instability of Rockwood grade III and more severe injuries. Various methods of coracoclavicular ligament reconstruction and augmentation have been described. The objective of this study is to compare the biomechanical properties of a novel palmaris-longus tendon reconstruction with those of the native AC+CC ligaments, the modified Weaver-Dunn reconstruction, the ACJ capsuloligamentous complex repair, screw and clavicle hook plate augmentation. 相似文献6.
7.
Varsha Patki Joe Virbasius William S. Lane Ban-Hock Toh Howard S. Shpetner Silvia Corvera 《Proceedings of the National Academy of Sciences of the United States of America》1997,94(14):7326-7330
Phosphatidylinositol 3-kinases (PI 3-kinases) have been implicated in membrane trafficking in the secretory and endocytic pathways of yeast and mammalian cells, but the molecular mechanisms by which these lipid kinases operate are not known. Here we identify a protein of 170 kDa that is rapidly released from cell membranes in response to wortmannin, a potent inhibitor of mammalian PI 3-kinases. The amino acid sequence of peptides from p170 reveal its identity to early endosomal antigen (EEA) 1, an endosomal antigen with homology to several yeast proteins genetically implicated in membrane trafficking. Immunofluorescence analysis of 3T3-L1 adipocytes with antisera against p170/EEA1 reveal a punctate peripheral pattern that becomes diffuse in response to wortmannin. In vitro, p170/EEA1 binds specifically to liposomes containing PIns(3)P, suggesting that the effect of wortmannin on cells is due to inhibition of PIns(3)P production. Thus, p170/EEA1 may define a family of proteins that mediate the regulatory effects of 3′-phosphoinositides on membrane trafficking in yeast and mammalian cells. 相似文献
8.
9.
Satomi-Kobayashi Seimi Kawashima Seinosuke Sakoda Tsuyoshi Ueyama Tomomi Hirase Tetsuaki Kawai Miki Toh Ryuji Iwai Kenji Yokoyama Mitsuhiro 《Circulation journal》2004,68(3):247-253
BACKGROUND: Glycogen synthase kinase-3 beta (GSK-3beta) is involved in many cellular processes, such as metabolism, apoptosis, differentiation and proliferation. Insulin-like growth factor-1 (IGF-1), which is well known to have a hypertrophic effect on cardiomyocytes, inactivates (phosphorylates) GSK-3beta in some cell types. The role of GSK-3beta in cardiomyocytes as a negative regulator of cardiac hypertrophy has been recently reported and the present study investigated the role of GSK-3beta in the cardiac hypertrophy of cultivated neonatal rat cardiomyocytes induced by IGF-1. METHODS AND RESULTS: First, the IGF-1 induced signal transduction leading to GSK-3beta in neonatal rat cardiomyocytes was examined. The phosphatidylinositol (PI) 3-kinase/Akt/GSK-3 beta signaling induced by IGF-1 was investigated using inhibitors of PI 3-kinase and Ad AktAA, a dominant negative form of Akt. Furthermore, using Ad MEK DN, a dominant negative form of MEK, it was found that MEK negatively regulates Akt phosphorylation upon IGF-1 stimulation. Next, it was examined whether GSK-3beta acts as a negative regulator in the cardiac hypertrophy induced by IGF-1. Sustained stimulation by IGF-1 caused cardiac hypertrophy in protein synthesis and cellular morphology, and overexpression of unphosphorylatable GSK-3beta (Ad GSK-3beta S9A) repressed these hypertrophic effects of IGF-1. CONCLUSIONS: GSK-3beta may play an important role as a negative regulator of cardiac hypertrophy induced by IGF-1. 相似文献
10.
The magnetic resonance (MR) images of six patients with thrombosis of a dural sinus were reviewed. The diagnosis had been verified by computed tomographic scans in three patients and arteriograms in two; in the sixth patient, only MR imaging was used to confirm the clinical syndrome. In all patients, high-intensity signal was seen from the thrombus within the affected dural sinus on all echoes. This persistent signal intensity allowed intravascular clot to be distinguished from normal causes of increased signal such as flow-related enhancement (entry phenomenon) and even-echo rephasing. MR imaging demonstrated the cause of the thrombosis in three patients: two were secondary to adjacent tumors, and one was secondary to unsuspected mastoiditis. Complications such as infarction were also demonstrated. Using MR imaging, one can easily and safely diagnose thrombosis of a dural sinus. MR should be the imaging method of choice in patients suspected of having thrombosis of a dural sinus. 相似文献