全文获取类型
收费全文 | 20788篇 |
免费 | 1490篇 |
国内免费 | 439篇 |
专业分类
耳鼻咽喉 | 289篇 |
儿科学 | 393篇 |
妇产科学 | 527篇 |
基础医学 | 3383篇 |
口腔科学 | 422篇 |
临床医学 | 1985篇 |
内科学 | 4034篇 |
皮肤病学 | 600篇 |
神经病学 | 1760篇 |
特种医学 | 583篇 |
外国民族医学 | 3篇 |
外科学 | 2264篇 |
综合类 | 1062篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 1368篇 |
眼科学 | 461篇 |
药学 | 1934篇 |
4篇 | |
中国医学 | 375篇 |
肿瘤学 | 1267篇 |
出版年
2023年 | 194篇 |
2022年 | 490篇 |
2021年 | 872篇 |
2020年 | 510篇 |
2019年 | 623篇 |
2018年 | 798篇 |
2017年 | 598篇 |
2016年 | 673篇 |
2015年 | 764篇 |
2014年 | 966篇 |
2013年 | 1235篇 |
2012年 | 1658篇 |
2011年 | 1792篇 |
2010年 | 1064篇 |
2009年 | 743篇 |
2008年 | 1007篇 |
2007年 | 1007篇 |
2006年 | 999篇 |
2005年 | 912篇 |
2004年 | 692篇 |
2003年 | 648篇 |
2002年 | 493篇 |
2001年 | 316篇 |
2000年 | 298篇 |
1999年 | 330篇 |
1998年 | 232篇 |
1997年 | 205篇 |
1996年 | 162篇 |
1995年 | 161篇 |
1994年 | 138篇 |
1993年 | 88篇 |
1992年 | 154篇 |
1991年 | 119篇 |
1990年 | 130篇 |
1989年 | 84篇 |
1988年 | 107篇 |
1987年 | 100篇 |
1986年 | 87篇 |
1985年 | 106篇 |
1984年 | 79篇 |
1983年 | 72篇 |
1982年 | 68篇 |
1981年 | 64篇 |
1980年 | 48篇 |
1979年 | 62篇 |
1978年 | 48篇 |
1977年 | 44篇 |
1976年 | 63篇 |
1975年 | 45篇 |
1973年 | 41篇 |
排序方式: 共有10000条查询结果,搜索用时 234 毫秒
1.
Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers
下载免费PDF全文
![点击此处可从《Asian Pacific journal of cancer prevention》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Thao Phuong Bui Phuong Lan LeLinh Thi Tu Nguyen Le Trung ThoThai Hong Trinh 《Asian Pacific journal of cancer prevention》2022,23(6):1893-1900
Background: Considering the poor prognosis of non-small cell lung cancer (NSCLC), the objective of this study was to examine the potential of plasma-derived vesicles as a source of lung cancer-specific proteins. Extracellular vesicle (EV) cargos are specific to the source cells, hence they have the potential of being a source of cancer-specific proteins. Methods: The proteins differently expressed in cancer were determined and derived from EVs isolated from the plasma of NSCLC patients at the National Lung Hospital. To this end, purification was done using gel filtration chromatography and ultracentrifugation. In addition, nano liquid chromatography mass spectrometry (LC–MS/MS) was used for analyzing. Results: Fifty-seven EV-derived proteins related to NSCLC were highlighted in this research. Some of them have not been addressed before, such as EEF1A1 (elongation factor 1-α1), KPNB1 (Importin subunit beta 1), SRC (proto-oncogene tyrosine-protein kinase) and ACTC1 (actin, alpha cardiac muscle 1). This list was further confirmed through a comparison with ExoCarta and Vesiclepedia. Conclusion: This study is the first work to show the involvement of several novel proteins of small EV (EEF1A1, KPNB1, SRC, and ACTC1) in the progression of NSCLC. The results suggested that they could serve as novel biomarkers for non-small cell lung cancer in the future. 相似文献
2.
3.
4.
5.
The analysis of quality of life (QoL) data can be challenging due to the skewness of responses and the presence of missing data. In this paper, we propose a new weighted quantile regression method for estimating the conditional quantiles of QoL data with responses missing at random. The proposed method makes use of the correlation information within the same subject from an auxiliary mean regression model to enhance the estimation efficiency and takes into account of missing data mechanism. The asymptotic properties of the proposed estimator have been studied and simulations are also conducted to evaluate the performance of the proposed estimator. The proposed method has also been applied to the analysis of the QoL data from a clinical trial on early breast cancer, which motivated this study. 相似文献
6.
Bielik Peter Bonczek Ondřej Krejčí Přemysl Zeman Tomáš Izakovičová-Hollá Lydie Šoukalová Jana Vaněk Jiří Vojtěšek Bořivoj Lochman Jan Balcar Vladimir J. Šerý Omar 《Clinical oral investigations》2022,26(12):7045-7055
Clinical Oral Investigations - The aim of this study was the analysis of WNT10A variants in seven families of probands with various forms of tooth agenesis and self-reported family history of... 相似文献
7.
Journal of Assisted Reproduction and Genetics - 相似文献
8.
9.
Increased arterial stiffness in young normotensive patients with Turner syndrome: associations with vascular biomarkers
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
10.