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排序方式: 共有291条查询结果,搜索用时 15 毫秒
1.
D. Lothschütz M. Jennewein S. Pahl H.F. Lausberg A. Eichler W. Mutschler R.G. Hanselmann M. Oberringer 《Inflammation research》2002,51(8):416-422
OBJECTIVE AND DESIGN: Inflammatory and tumorous bronchi were screened in order to obtain new tumor relevant cytogenetic parameters. MATERIAL OR SUBJECTS: Bronchial cells of 32 patients were cultivated by standard cell culture procedures. METHODS: Tetraploidy and aneuploidy was determined by enumeration of chromosome 7 and 8 versus the number of centrosomes. The resulting data were correlated with histopathological data. RESULTS: Tetra- and aneuploidy of epithelial cells were detectable in 76% of tumor cell cultures, 75% of high grade inflammatory tissues and 40% of non- and low grade-inflammatory tissues. Additionally, we observed centrosome hyper-amplification and multipolar mitoses not only in the tumor but also in the early stages of inflammation. CONCLUSION: Inflammatory bronchi already show tumor-specific features and may consequently represent the preliminary genetic stage of cancer development in bronchi. 相似文献
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一些保肝药物对原代培养大鼠肝细胞糖原合成功能的影响 总被引:1,自引:0,他引:1
本文参照PO Seglen的方法并加以修改,建立了原代培养大鼠肝细胞糖原合成功能的测定体系。观察到联苯双酯既能使正常肝细胞合成糖原增加88%,又能保护肝细胞完全拮抗四氯化碳对其功能的损伤;银耳多糖能使四氯化碳对肝细胞糖原合成功能的损伤减轻57%;去甲斑蝥素10μg/ml能增加肝细胞糖原合成,浓度增加到100μg/ml时,此作用减弱,1000μg/ml则明显抑制糖原的合成,而且在10~100μg/ml浓度时,即能加强四氯化碳的损伤作用;100μg/ml CL1500和熊果酸二钠单独应用可增加肝细胞糖原合成,但与四氯化碳同时应用,反而加重对糖原合成的抑制作用。 相似文献
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Differential recruitment of CD8+ macrophages during Wallerian degeneration in the peripheral and central nervous system 总被引:7,自引:0,他引:7
The strong macrophage response occurring during Wallerian degeneration in the peripheral but not central nervous system has been implicated in tissue remodeling and growth factor production as key requirements for successful axonal regeneration. We have previously identified a population of CD8+ phagocytes in ischemic brain lesions that differed in its recruitment pattern from CD4+ macrophages/microglia found in other lesion paradigms. In the present study we show that crush injury to the sciatic nerve induced strong infiltration by CD8+ macrophages both at the crush site and into the degenerating distal nerve stump. At the crush site, CD8+ macrophages appeared within 24 hours whereas infiltration of the distal nerve parenchyma was delayed to the second week. CD8+ macrophages were ED1+ and CD11b+ but always MHC class II-. Most CD8+ macrophages coexpressed CD4 while a significant number of CD4+/CD8-macrophages was also present. Expression of the resident tissue macrophage marker ED2 was largely restricted to the CD4+/CD8- population. Following intraorbital crush injury to the optic nerve, infiltration of CD8+ macrophages was strictly confined to the crush site. Taken together, our study demonstrates considerable spatiotemporal diversity of CD8+ macrophage responses to axotomy in the peripheral and central nervous system that may have implications for the different extent of axonal regeneration observed in both systems. 相似文献
6.
Dal Zotto L; Quaderi NA; Elliott R; Lingerfelter PA; Carrel L; Valsecchi V; Montini E; Yen CH; Chapman V; Kalcheva I; Arrigo G; Zuffardi O; Thomas S; Willard HF; Ballabio A; Disteche CM; Rugarli EI 《Human molecular genetics》1998,7(3):489-499
We have recently reported isolation of the gene responsible for X- linked
Opitz G/BBB syndrome, a defect of midline development. MID1 is located on
the distal short arm of the human X chromosome (Xp22. 3) and encodes a
novel member of the B box family of zinc finger proteins. We have now
cloned the murine homolog of MID1 and performed preliminary expression
studies during development. Mid1 expression in undifferentiated cells in
the central nervous, gastrointestinal and urogenital systems suggests that
abnormal cell proliferation may underlie the defect in midline development
characteristic of Opitz syndrome. We have also found that Mid1 is located
within the mouse pseudoautosomal region (PAR) in Mus musculus , while it
seems to be X- specific in Mus spretus. Therefore, Mid1 is likely to be a
recent acquisition of the M. musculus PAR. Genetic and FISH analyses also
demonstrated a high frequency of unequal crossovers in the murine PAR,
creating spontaneous deletion/duplication events involving Mid1. These data
provide evidence for the first time that genetic instability of the PAR may
affect functionally important genes. In addition, we show that MID1 is the
first example of a gene subject to X-inactivation in man while escaping it
in mouse. These data contribute to a better understanding of the molecular
content and evolution of the rodent PAR.
相似文献
7.
G. Lausberg 《Acta neurochirurgica》1965,13(3-4):517-543
Zusammenfassung Nach Darlegung technischer und ballistischer Einzelheiten über Handfeuerwaffen und eine klinische Einleitung wird über 20 eigene Fälle mit Schädelschußverletzungen berichtet. 16 Verletzungen gingen mit direkter Gehirnbeteiligung einher, 12 von denen verstarben. Es wird auf die Wichtigkeit der Kenntnis der Tatwaffen und des Schußkanalverlaufs im Röntgenbild verwiesen, und die besondere Bedeutung der Bewußtseinslage, der neurologischen Symptomatik und der Schocksituation zur prognostischen Bewertung dieser Verletzungen herausgestellt.
Summary After setting out technical and ballistic details of small arms and after a clinical introduction, a series of 20 personal cases with gun-shot wounds of the head are described. Sixteen patients had direct involvement of the brain, of whom 12 died. The importance of a knowledge of the weapon used and of the course of the missile as seen in the radiographs is referred to. It is demonstrated that in these patients the level of consciousness, the neurological symptoms and the degree of shock are of especial importance in assessing prognosis.
Resumen Después de un breve resumen de los detalles técnicos y balísticos de armas de fuego y tras una introduction clínica se analiza una serie de 20 casos personales de heridas craneales por arma de fuego. De 16 enfermos que tuvieron lesiones cerebrales 12 fallecieron. El autor insiste sobre la importancia del conocimiento del arma utilizada, así como del trayecto de la bala visto en las radiografías. En estos enfermos el nivel de conciencia, los signos neurológicos y el grado de shock tienen una gran importancia para el pronóstico.
Résumé Après un bref rappel des détails techniques et ballistiques des armes légères, et après une introduction clinique, une série de 20 cas personnels de blessures cranielles par coup de fusil est rapportée. Sur 16 malades qui ont eu des lésions cérébrales: 12 sont décédés. L'auteur insiste sur l'importance de la connaissance de l'arme utilisée et du trajet de la balle vu sur les clichés. Chez ces malades, le niveau de conscience, les signes neurologiques et le degré du choc ont une grande importance dans le pronostic.
Riassunto Vengono discussi venti casi di ferite craniche da arma da fuoco, 16 dei quali avevano una compromissione cerebrale. Di essi 12 sono morti. Viene praticamente discussa l'importanza della conoscenza della forza di penetrazione della pallottola nei radiogrammi e della localizzazione del canale di entrata e di uscita e della situazione neurologica e dello stato di shock per la prognosi di questi feriti.相似文献
8.
Lausberg HF Graeter TP Wendler O Demertzis S Ukena D Schäfers HJ 《The Annals of thoracic surgery》2000,70(2):367-71; discussion 371-2
BACKGROUND: To improve postoperative pulmonary reserve, we have employed parenchyma-sparing resections for central lung tumors irrespective of pulmonary function. The results of lobectomy, pneumonectomy, and sleeve resection were analyzed retrospectively. METHODS: From October 1995 to June 1999, 422 typical lung resections were performed for lung cancer. Of these, 301 were lobectomies (group I), 81 were sleeve resections (group II), and 40 were pneumonectomies (group III). RESULTS: Operative mortality was 2% in group I, 1.2% in group II, and 7.5% in group III (group I and II vs. group III, p<0.03). Mean time of intubation was 1.0+/-4.1 days in group I, 0.9+/-1.3 days in group II, and 3.6+/-11.2 days in group III (groups I and II vs. group III, p<0.01). The incidence of bronchial complications was 1.3% in group I, none in group II, and 7.5% in group III (group I and II vs group III, p<0.001). After 2 years, survival was 64% in group I, 61.9% in group II, and 56.1% in group III (p = NS). Freedom from local disease recurrence was 92.1% in group I, 95.7% in group II, and 90.9% in group III after 2 years (p = NS). CONCLUSIONS: Sleeve resection is a useful surgical option for the treatment of central lung tumors, thus avoiding pneumonectomy with its associated risks. Morbidity, early mortality, long-term survival, and recurrence of disease after sleeve resection are similar to those seen after lobectomy. 相似文献
9.
Enio R Vasques Estela RR Figueira Joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena B Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues José EM Cunha Eleazar Chaib Luiz AC D'Albuquerque Flávio HF Galv?o 《Hepatobiliary & pancreatic diseases international : HBPD INT》2022,21(2):190-192
<正>To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan failure.Intracellular calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca2+,showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1], 相似文献
10.
G. M. Downes M. Lausberg B. M. Potts D. L. Pilbeam M. Bird B. Bradshaw 《Australian forestry.》2018,81(3):177-185
Average bark-to-bark resistance of the IML Resistograph PD400 (hereafter referred to as ‘Resi’) was found to provide strong linear correlations with the basic density of 12-mm-diameter increment cores taken from standing plantation eucalypt trees. Relationships between Resi values and approximately 2 000 cores (predominantly Eucalyptus globulus but some E. nitens) were examined across seven studies (representing samples from nine distinct sites) in Tasmania, Victoria and Western Australia. Custom-written software was developed to process the Resi traces to automatically perform a linear baseline correction of the trace, and extract:
over-bark and under-bark diameter
bark thickness
average resistance of the bark-to-bark (under-bark) trace
average resistance of the outer 50 mm on the entry and exit side of the traces.