首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2510433篇
  免费   191006篇
  国内免费   7143篇
耳鼻咽喉   32668篇
儿科学   82396篇
妇产科学   70204篇
基础医学   362926篇
口腔科学   68782篇
临床医学   236087篇
内科学   489171篇
皮肤病学   54030篇
神经病学   208983篇
特种医学   93431篇
外国民族医学   804篇
外科学   358478篇
综合类   56498篇
现状与发展   5篇
一般理论   969篇
预防医学   211417篇
眼科学   55868篇
药学   180555篇
  7篇
中国医学   5839篇
肿瘤学   139464篇
  2021年   20248篇
  2019年   21507篇
  2018年   29959篇
  2017年   22863篇
  2016年   25389篇
  2015年   28699篇
  2014年   40198篇
  2013年   60758篇
  2012年   83501篇
  2011年   88375篇
  2010年   51455篇
  2009年   48690篇
  2008年   81142篇
  2007年   85637篇
  2006年   86165篇
  2005年   83283篇
  2004年   78991篇
  2003年   75428篇
  2002年   72688篇
  2001年   116101篇
  2000年   119279篇
  1999年   99744篇
  1998年   28952篇
  1997年   26182篇
  1996年   26020篇
  1995年   24725篇
  1994年   22749篇
  1993年   21340篇
  1992年   77160篇
  1991年   74726篇
  1990年   72390篇
  1989年   68761篇
  1988年   63613篇
  1987年   61855篇
  1986年   58357篇
  1985年   55679篇
  1984年   42245篇
  1983年   35963篇
  1982年   21856篇
  1981年   19367篇
  1979年   38022篇
  1978年   26869篇
  1977年   22279篇
  1976年   21383篇
  1975年   21922篇
  1974年   26671篇
  1973年   26041篇
  1972年   24056篇
  1971年   22225篇
  1970年   20907篇
排序方式: 共有10000条查询结果,搜索用时 19 毫秒
1.
2.
3.
4.
5.
6.
7.
8.

Introduction

Physician communication impacts patient outcomes. However, communication skills, especially around difficult conversations, remain suboptimal, and there is no clear way to determine the validity of entrustment decisions. The aims of this study were to 1) describe the development of a simulation-based mastery learning (SBML) curriculum for breaking bad news (BBN) conversation skills and 2) set a defensible minimum passing standard (MPS) to ensure uniform skill acquisition among learners.

Innovation

An SBML BBN curriculum was developed for fourth-year medical students. An assessment tool was created to evaluate the acquisition of skills involved in a BBN conversation. Pilot testing was completed to confirm improvement in skill acquisition and set the MPS.

Outcomes

A BBN assessment tool containing a 15-item checklist and six scaled items was developed. Students' checklist performance improved significantly at post-test compared to baseline (mean 65.33%, SD = 12.09% vs mean 88.67%, SD = 9.45%, P < 0.001). Students were also significantly more likely to have at least a score of 4 (on a five-point scale) for the six scaled questions at post-test. The MPS was set at 80%, requiring a score of 12 items on the checklist and at least 4 of 5 for each scaled item. Using the MPS, 30% of students would require additional training after post-testing.

Comments

We developed a SBML curriculum with a comprehensive assessment of BBN skills and a defensible competency standard. Future efforts will expand the mastery model to larger cohorts and assess the impact of rigorous education on patient care outcomes.  相似文献   
9.
Abstract

Objectives: This study examined word use as an indicator of interpersonal positive reframing in daily conversations of couples coping with breast cancer and as a predictor of stress.

Design: The Electronically Activated Recorder (EAR) and Linguistic Inquiry and Word Count (LIWC) were used to examine naturally occurring word use conceptually linked to positive reframing (positive emotion, negative emotion, and cognitive processing words).

Sample: Fifty-two couples coping with breast cancer.

Methods: Couples wore the EAR, a device participants wear, that audio-recorded over one weekend (>16,000 sound files), and completed self-reports of positive reframing (COPE) and stress (Perceived Stress Scale). LIWC, a software program, measured word use.

Findings: Both partners’ word use (i.e., positive emotion and cognitive processing words) was associated with their own reported positive reframing, and spouses’ word use was also indicative of patients’ positive reframing. Results also revealed that, in general, words indicating positive reframing predicted lower levels of stress.

Conclusions: Findings supported the hypothesis that partners—and particularly spouses of breast cancer patients—may assist each other’s coping by positively reframing the cancer experience and other negative experiences in conversation.  相似文献   
10.

Background

Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.

Objectives

To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.

Methods

Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.

Results

Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.

Conclusions

These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号