全文获取类型
| 收费全文 | 2441005篇 |
| 免费 | 186484篇 |
| 国内免费 | 7006篇 |
专业分类
| 耳鼻咽喉 | 32028篇 |
| 儿科学 | 80465篇 |
| 妇产科学 | 68704篇 |
| 基础医学 | 352437篇 |
| 口腔科学 | 66770篇 |
| 临床医学 | 229806篇 |
| 内科学 | 475956篇 |
| 皮肤病学 | 52992篇 |
| 神经病学 | 202001篇 |
| 特种医学 | 90579篇 |
| 外国民族医学 | 790篇 |
| 外科学 | 350473篇 |
| 综合类 | 56203篇 |
| 现状与发展 | 4篇 |
| 一般理论 | 896篇 |
| 预防医学 | 202530篇 |
| 眼科学 | 54649篇 |
| 药学 | 176324篇 |
| 7篇 | |
| 中国医学 | 5684篇 |
| 肿瘤学 | 135197篇 |
出版年
| 2021年 | 19144篇 |
| 2019年 | 20377篇 |
| 2018年 | 28575篇 |
| 2017年 | 21691篇 |
| 2016年 | 24096篇 |
| 2015年 | 27192篇 |
| 2014年 | 38160篇 |
| 2013年 | 58161篇 |
| 2012年 | 79249篇 |
| 2011年 | 84112篇 |
| 2010年 | 49192篇 |
| 2009年 | 46287篇 |
| 2008年 | 77383篇 |
| 2007年 | 81823篇 |
| 2006年 | 82478篇 |
| 2005年 | 79803篇 |
| 2004年 | 76035篇 |
| 2003年 | 72620篇 |
| 2002年 | 70126篇 |
| 2001年 | 114113篇 |
| 2000年 | 117279篇 |
| 1999年 | 97861篇 |
| 1998年 | 28039篇 |
| 1997年 | 25469篇 |
| 1996年 | 25284篇 |
| 1995年 | 24122篇 |
| 1994年 | 22206篇 |
| 1993年 | 20847篇 |
| 1992年 | 75905篇 |
| 1991年 | 73543篇 |
| 1990年 | 71261篇 |
| 1989年 | 67696篇 |
| 1988年 | 62597篇 |
| 1987年 | 60973篇 |
| 1986年 | 57510篇 |
| 1985年 | 54847篇 |
| 1984年 | 41648篇 |
| 1983年 | 35426篇 |
| 1982年 | 21584篇 |
| 1981年 | 19103篇 |
| 1979年 | 37526篇 |
| 1978年 | 26587篇 |
| 1977年 | 22040篇 |
| 1976年 | 21180篇 |
| 1975年 | 21701篇 |
| 1974年 | 26415篇 |
| 1973年 | 25764篇 |
| 1972年 | 23829篇 |
| 1971年 | 21983篇 |
| 1970年 | 20705篇 |
排序方式： 共有10000条查询结果，搜索用时 12 毫秒
1.
2.
3.
4.
5.
6.
7.
Julia H. Vermylen Gordon J. Wood Elaine R. Cohen Jeffrey H. Barsuk William C. McGaghie Diane B. Wayne 《Journal of pain and symptom management》2019,57(3):682-687
Introduction
Physician communication impacts patient outcomes. However, communication skills, especially around difficult conversations, remain suboptimal, and there is no clear way to determine the validity of entrustment decisions. The aims of this study were to 1) describe the development of a simulation-based mastery learning (SBML) curriculum for breaking bad news (BBN) conversation skills and 2) set a defensible minimum passing standard (MPS) to ensure uniform skill acquisition among learners.Innovation
An SBML BBN curriculum was developed for fourth-year medical students. An assessment tool was created to evaluate the acquisition of skills involved in a BBN conversation. Pilot testing was completed to confirm improvement in skill acquisition and set the MPS.Outcomes
A BBN assessment tool containing a 15-item checklist and six scaled items was developed. Students' checklist performance improved significantly at post-test compared to baseline (mean 65.33%, SD = 12.09% vs mean 88.67%, SD = 9.45%, P < 0.001). Students were also significantly more likely to have at least a score of 4 (on a five-point scale) for the six scaled questions at post-test. The MPS was set at 80%, requiring a score of 12 items on the checklist and at least 4 of 5 for each scaled item. Using the MPS, 30% of students would require additional training after post-testing.Comments
We developed a SBML curriculum with a comprehensive assessment of BBN skills and a defensible competency standard. Future efforts will expand the mastery model to larger cohorts and assess the impact of rigorous education on patient care outcomes. 相似文献8.
Megan L. Robbins Robert C. Wright Ana María López Karen Weihs 《Journal of psychosocial oncology》2019,37(2):160-177
AbstractObjectives: This study examined word use as an indicator of interpersonal positive reframing in daily conversations of couples coping with breast cancer and as a predictor of stress.Design: The Electronically Activated Recorder (EAR) and Linguistic Inquiry and Word Count (LIWC) were used to examine naturally occurring word use conceptually linked to positive reframing (positive emotion, negative emotion, and cognitive processing words).Sample: Fifty-two couples coping with breast cancer.Methods: Couples wore the EAR, a device participants wear, that audio-recorded over one weekend (>16,000 sound files), and completed self-reports of positive reframing (COPE) and stress (Perceived Stress Scale). LIWC, a software program, measured word use.Findings: Both partners’ word use (i.e., positive emotion and cognitive processing words) was associated with their own reported positive reframing, and spouses’ word use was also indicative of patients’ positive reframing. Results also revealed that, in general, words indicating positive reframing predicted lower levels of stress.Conclusions: Findings supported the hypothesis that partners—and particularly spouses of breast cancer patients—may assist each other’s coping by positively reframing the cancer experience and other negative experiences in conversation. 相似文献
9.
Jae Eun Choi Tyler Werbel Zhenping Wang Chia Chi Wu Tony L. Yaksh Anna Di Nardo 《Journal of dermatological science》2019,93(1):58-64
Background
Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.Objectives
To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.Methods
Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.Results
Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.Conclusions
These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study. 相似文献10.
M. Iachina P.M. Ljungdalh R.G. Sørensen L. Kaerlev J. Blaakær O. Trosko N. Qvist B.M. Nørgård 《Clinical oncology (Royal College of Radiologists (Great Britain))》2019,31(2):115-123