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SMITH-KIELLAND ANNE; SVENDSEN LENE; BESSESEN ATLE; MORLAND JORG 《Alcohol and alcoholism (Oxford, Oxfordshire)》1983,18(4):285-292
Hepatic protein synthesis was studied in male and female ratsfed ethanol-supplemented diets for 67 weeks. In one group(group 1), male rats were fed an all-liquid diet with 36% ofthe energy as ethanol. The controls were pair-fed with carbohydratereplacing ethanol isoenergetically. The second group of malerats (group 2) was given a mixture of solid and liquid diets.The solid food was given ad libitum and was supplemented witheither an ethanol-containing liquid (2030% of energyas ethanol) or isoenergetic amounts of lipid. Female rats (group3) received the same diet regimen as group 2. Rates of hepaticprotein synthesis were measured after a 1218 hr fastby a 32 min continuous infusion of 3H-valine. Specific precursorradioactivity (valyl tRNA) was calculated from valine specificradioactivities and concentrations in intra- and extracellularwater at 12, 22 and 32 min. The rates of protein synthesis were lower in all three groupsof ethanol-treated rats than in controls. In group 1, ethanolfeeding resulted in protein accumulation, and the plasma proteinconcentration was significantly lower at 20 and 32 min. In conclusion,female and male rats fed various diets were susceptible to thesame inhibitory effect of chronic ethanol consumption on hepaticprotein synthesis. 相似文献
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JORG SEEBACH RUDOLF SPEICH JORG FEHR PETER TUCHSCHMID ERICH RUSSI 《British journal of haematology》1995,90(4):963-965
Summary. There is increasing evidence that haemopoietic growth factors are effective in reversal of neutropenia associated with large granular lymphocytes (LGLs) proliferation. A 19-year-old woman with CD3+ /TCRγδ+ , CD4− , CD8− LGL proliferation and severe neutropenia repeatedly developed blood eosinophilia, fever and dyspnoea after administration of GM-CSF. Acute eosinophilic pneumonia with a lobar lung infiltrate pleural effusion, and marked bronchoalveolar lavage fluid eosinophilia was diagnosed. Treatment with corticosteroids and discontinuation of GM-CSF lead to rapid improvement. In addition, haematological analysis revealed that H*1 Technicon, a widely-used automated cell counter, may misinterpret eosinophils erroneously as neutrophils, therefore examination of blood smears to prevent eosinophil-medlated toxicity during GM-CSF treatment is recommended. 相似文献
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LUDGER GROTE JÖRG HEITMANN THOMAS PENZEL WERNER CASSEL THOMAS PLOCH JORG HERMANN PETER PETER VON WICHERT 《Journal of sleep research》1995,4(S1):112-116
SUMMARY Male patients with arterial hypertension and obstructive sleep-related breathing disorders (mean age 50 y, Body Mass Index (BMI) 32.4 kg m-2 , Respiratory Disturbance Index (RDI) 47.2 and systolic/diastolic blood pressure (SBD/DBD) 162/103 mmHg) were examined before and after 8 days of treatment with the long-acting angiotensin-converting-enzyme (ACE) inhibitor cilazapril 2.5 mg vs. placebo in a double-blind design with parallel groups. Cardiorespiratory polysom-nography was carried out at night; during daytime wakefulness patients submitted to examinations of physical and mental exertion. Cilazapril reduced the mean pressure during the entire examination period (day and night) by 9.55 (SD±7.13) mmHg, compared to 4.57 (SD ±7.20) mmHg for placebo ( P < 0.006), independently from systematic changes of heart rate ( x = -3.3 and -3.5 bpm, respectively). During REM sleep, mean arterial pressure was significantly reduced by 8.63 (SD ±10.1) mmHg, compared to a reduction on placebo of 3.17 (SD 9.6) mmHg ( P = 0.023). Under psychometric strain, the mean arterial pressure was reduced by 15.31 (SD ±8.7) mmHg with cilazapril; under placebo medication by 6.19 (SD ±7.3) mmHg ( P < 0.0001). Heart rate was not significantly changed. 相似文献
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ARMIN HEISEL M.D. JENS JUNG M.D. JORG NEUZNER M.D. ULI MICHEL B.S.B.M.E. HEINZ PITSCHNER M.D. 《Journal of cardiovascular electrophysiology》1997,8(6):607-617
Atrial Cardioversion Using a Single Atrial Lead System. Introduction: Clinical studies have shown that electrical conversion of atrial fibrillation (AF) is feasible with transvenous catheter electrodes at low energies. We developed a single atrial lead system that allows atrial pacing, sensing, and defibrillation to improve and facilitate this new therapeutic option. Methods and Results: The lead consists of a tripolar sensing, pacing, and defibrillation system. Two defibrillation coil electrodes are positioned on a stylet-guided lead. A ring electrode located between the two coils serves as the cathode for atrial sensing and pacing. We used this lead to cardiovert patients with acute or chronic AE. The distal coil was positioned in the coronary sinus, and the proximal coil and the ring electrode in the right atrium. R wave synchronized biphasic shocks were delivered between the two coils. Atrial signal detection and pacing were performed using the proximal coil and the ring electrode. Eight patients with acute AF (38 ± 9 min) and eight patients with chronic AF (6.6 ± 5 months) were included. The fluoroscopy time for lead placement was 3.5 ± 4.3 minutes. The atrial defibrillation threshold was 2.0 ± 1.4 J for patients with acute AE and 9.2 ± 5.9 J for patients with chronic AF (P < 0.01). The signal amplitude detected was 1.7 ± 1.1 mV during AF and 4.0 ± 2.9 mV after restoration of sinus rhythm (P < 0.001). Atrial pacing was feasible at a threshold of 4.4 ± 3.3 V (0.5-msec pulse width). Conclusions: Atrial signal detection, atrial pacing, and low-energy atrial defibrillation using this single atrial lead system is feasible in various clinical settings. Tbis system might lead to a simpler, less invasive approach for internal atrial cardioversion. 相似文献
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The incorporation of 14C-valine into liver protein was studiedin isolated rat liver parenchymal cells. Various glucose levelsin the incubation media did not affect the rate of 14C-valineincorporation into proteins. The insulin stimulated incorporationof 14C-valine into proteins was also unaffected by the variousglucose levels. Ethanol decreased the incorporation of 14C-valineinto liver proteins, affecting stationary and export proteinsto the same extent. This inhibitory action of ethanol on valineincorporation was reversed by increasing exogenous glucose concentrations.The combination of insulin and high glucose level totally preventedthe ethanol inhibition. 相似文献
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Implantable cardioverter defibrillators (ICDs) are being implanted in increasing numbers. At inlraoperative defibrillation threshold tests refractory ventricular fibrillation (VF) requiring emergency open chest resuscitation is a major concern during impiantation of nonthoracotomy ICD lead systems. A new method of high energy endocardial/extrathoracic defibrillotion via the implanted ICD transvenous defibrillation electrode (TDE) was used to terminate refractory VF. During implantation of ICD with TDE in 20 patients refractory VF occurred in two patients. The arrhythmia was terminated with endocardial/extrathoracic defibrillation in both cases, and no complications were observed. 相似文献
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SAUL MALOZOWSKI SANTIAGO MUZZO RAQUEL BURROWS LAURA LEIVA LYNN LORIAUX GEORGE CHROUSOS JORG WINTERER FERNANDO CASSORLA 《Clinical endocrinology》1990,32(4):461-466
We studied the circadian rhythm and the response of the hypothalamic-pituitary-adrenal (HPA) axis to ovine corticotrophin releasing hormone (oCRH) stimulation and dexamethasone suppression in 32 children with grade II-III marasmus. Children were studied prior to and after nutritional rehabilitation. Mean baseline plasma cortisol concentrations were elevated at admission and decreased significantly after nutritional rehabilitation. Mean +/- SEM plasma cortisol response to oCRH increased from a basal of 480 +/- 41 to a peak of 582 +/- 58 nmol/l at the time of admission, and from a basal of 234 +/- 27 to a peak of 532 +/- 41 nmol/l after caloric rehabilitation. Dexamethasone suppression in the malnourished group was associated with a decrease in the mean +/- SEM basal plasma cortisol concentration from 397 +/- 44 to 171 +/- 44 nmol/l. After caloric rehabilitation, basal cortisol levels decreased from 259 +/- 27 to 22 +/- 5 nmol/l following dexamethasone. Our results support the concept that malnutrition is associated with decreased responsiveness to oCRH and incomplete dexamethasone suppression, and that these abnormalities are restored after nutritional rehabilitation. 相似文献
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HARTMUT P.H. NEUMANN BERNHARD U. BENDER DIETMAR P. BERGER JORG LAUBENBERGER WOLFGANG SCHULTZE-SEEMANN ULRICH WETTERAUER FRANZ JOSEF FERSTL EBERHARD W. HERBST GEORG SCHWARZKOPF FREDERIK J. HES CORNELIS LIPS J. M. JAMES M. LAMIELL OTAKAR MASEK PETER RIEGLER BARBARA MUELLER DAMJAN GLAVAC HILTRUD BRAUCH 《The Journal of urology》1998,160(4):1248-1254