全文获取类型
收费全文 | 210263篇 |
免费 | 2596篇 |
国内免费 | 167篇 |
专业分类
耳鼻咽喉 | 1552篇 |
儿科学 | 7241篇 |
妇产科学 | 3611篇 |
基础医学 | 21210篇 |
口腔科学 | 2817篇 |
临床医学 | 14991篇 |
内科学 | 39206篇 |
皮肤病学 | 1489篇 |
神经病学 | 18989篇 |
特种医学 | 10193篇 |
外科学 | 34508篇 |
综合类 | 2563篇 |
一般理论 | 2篇 |
预防医学 | 19154篇 |
眼科学 | 3234篇 |
药学 | 11774篇 |
中国医学 | 707篇 |
肿瘤学 | 19785篇 |
出版年
2022年 | 388篇 |
2021年 | 680篇 |
2020年 | 327篇 |
2019年 | 489篇 |
2018年 | 22475篇 |
2017年 | 17744篇 |
2016年 | 19906篇 |
2015年 | 1504篇 |
2014年 | 1603篇 |
2013年 | 1647篇 |
2012年 | 8376篇 |
2011年 | 22466篇 |
2010年 | 19573篇 |
2009年 | 12266篇 |
2008年 | 20809篇 |
2007年 | 23097篇 |
2006年 | 2112篇 |
2005年 | 3828篇 |
2004年 | 4945篇 |
2003年 | 5858篇 |
2002年 | 4061篇 |
2001年 | 1505篇 |
2000年 | 1822篇 |
1999年 | 1428篇 |
1998年 | 676篇 |
1997年 | 572篇 |
1996年 | 469篇 |
1995年 | 440篇 |
1994年 | 377篇 |
1993年 | 327篇 |
1992年 | 862篇 |
1991年 | 856篇 |
1990年 | 829篇 |
1989年 | 797篇 |
1988年 | 758篇 |
1987年 | 718篇 |
1986年 | 726篇 |
1985年 | 643篇 |
1984年 | 470篇 |
1983年 | 389篇 |
1982年 | 202篇 |
1979年 | 351篇 |
1978年 | 249篇 |
1977年 | 214篇 |
1975年 | 213篇 |
1974年 | 251篇 |
1973年 | 211篇 |
1971年 | 213篇 |
1970年 | 225篇 |
1969年 | 247篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
Takaharu Negoro Kanami Orihara Tomoko Irahara Hiroshi Nishiyama Kanae Hagiwara Risa Nishida Hiroki Takagi Kazue Satoh Yoshiki Yamamoto Shunichi Shimizu Tamio Hagiwara Masakazu Ishii Toshihiro Tanioka Yasuko Nakano Ken Takeda Isao Yoshimura Yoji Iikura Takashi Tobe 《Pediatric allergy and immunology》2006,17(8):583-590
Although many single nucleotide polymorphism (SNP) studies have reported an association of atopy, allergic diseases and total serum immunoglobulin E (IgE) levels, almost all of these studies sought risk factors for the onset of these allergic diseases. Furthermore, many studies have analyzed a single gene and hardly any have analyzed environmental factors. In these analyses, the results could be masked and the effects of other genes and environmental factors may be decreased. Here, we described the correlation between four genes [interleukin (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in connection with IgE production; the role of IL-10 (C-627A) as a regulatory cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) in 220 Japanese allergic children. In addition to these SNPs, environmental factors, i.e., patient's attitude, indoor environment, and so on, were also investigated in this study. Our study was retrospective, and the correlation was analyzed by our defined clinical scores divided into three terms: worst symptoms, recent symptoms and general amelioration at the most recent examination during the disease course. Our results indicated that IL-10 AA, the genotype with lower IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, estimate; 0.912). Marginal liver abnormalities were observed in the subject group with both FA and AE (p < 0.1191, estimate; 0.1490). Our defined clinical scores enabled evaluation of various aspects of disease severity. Based on the scores, while no single SNP selected in this study determined severity, the combination of the SNP with laboratory data and environmental factors appeared to determine severity. 相似文献
3.
4.
5.
6.
Satoshi Iyama Yasuo Takahashi Naoaki Shintani Koshi Fujikawa Syunichi Ohkubo Yasushi Sato Tsutomu Sato Yasuhiro Sato Keisuke Ohnuma Yoshiro Niitsu 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1163-1168
We report a case of biliary cystadenocarcinoma which recurred 41 months postoperatively. A 60-year-old woman was admitted for further examination of multiple metastatic tumors and a large amount of ascites. Systemic administration of 5FU and CDDP caused her CEA level to decrease gradually and abdominal computed tomography revealed considerable reduction of the metastatic tumors and ascites. Since her general condition had improved, chemotherapy was continued in the outpatient clinic. 相似文献
7.
8.
Kensaku Maeda Kenichi Yasunari Eisuke F Sato Junichi Yoshikawa Masayasu Inoue 《Hypertension research》2003,26(12):999-1006
The involvement of oxidative stress in polymorphonuclear leukocytes (PMN) in the pathogenesis of hypertension remains to be elucidated. We analyzed the generation of reactive oxygen species (ROS) by the circulating and peritoneally infiltrating PMN from spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Flow cytometric analysis revealed that ROS generation by PMN from SHR was higher than that from WKY before (at 6 weeks of age) and after (at 16 weeks of age) the onset of hypertension. In vivo, ROS generation by PMN from SHR, but not that by PMN from WKY, was significantly suppressed by 10-week treatment with 50 mg/kg/day carvedilol, and this treatment did not affect blood pressure. Western blotting analysis revealed that protein kinase C alpha (PKCalpha), but not PKCbetaI or betaII, was activated more strongly in PMN from SHR than in PMN from WKY. Furthermore, expression of p47phox of nicotinamide adenine dinucleotide phosphate oxidase, but not of p67phox, in PMN from SHR was higher than that in PMN from WKY. These results suggest that ROS generation by PMN is principally enhanced in SHR through activation of PKCalpha and p47phox. 相似文献
9.
Susanne Ramsauer 《Zeitschrift für Psychodrama und Soziometrie》2007,6(2):293-302
Anliegen dieses Artikels ist, die besondere Qualit?t und Chance von Psychodramatischer Supervision zu beschreiben, und gleichzeitig
die Kompatibilit?t und fruchtbare Erg?nzung des Moreno’schen Ansatzes innerhalb des Formats Supervision innerhalb der Sozialen
Arbeit auf zuzeigen. Dies wird anhand von 2 ausgew?hlten Praxisbeispielen dargestellt. Die Handlungskompetenz von Supervisandinnen
und Supervisanden kann durch einfache psychodramatische Interventionen erweitert werden. Handlungshemmung wird überwunden,
Spontaneit?t und Kreativit?t kommen ins Laufen und er?ffnen Perspektiven. 相似文献
10.