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M J Glynn J Powell-Tuck D A Reaveley I M Murray-Lyon 《JPEN. Journal of parenteral and enteral nutrition》1988,12(5):457-461
We have conducted a randomized double crossover study over 4 days in six parenterally fed patients with portasystemic encephalopathy (PSE) in which the nonprotein energy source of otherwise identical feeds was alternately all glucose or predominantly fat. Concentrations of plasma branched chain amino acids (BCAA), plasma insulin, and blood glucose were measured after an initial fast and subsequently after each of the four 24-hr periods of isonitrogenous feeding. The grade of PSE was assessed clinically and by the number connection test, BCAA concentrations were significantly lower during the glucose infusion than during fasting or the lipid infusion. PSE was significantly less with the lipid than with the glucose infusion. Trials testing the effect of infused BCAA must take account of the opposing effect on BCAA concentrations of simultaneous glucose infusion. A high lipid feed may have advantages in the short-term treatment of PSE. 相似文献
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Karen A Luker PhD BNurs RGN RHV NDNCert Kinta Beaver BA RGN DPSN Samuel J Leinster BSc MD FRCS R Glynn Owens BTech DipPsych DPhil AFBPsS Lesley F Degner PhD RN Jeffrey A Sloan PhD BSc 《Journal of advanced nursing》1995,22(1):134-141
Nurses can play a key role in patient education, including providing patients with useful and approrate information Rather than focusing on the process of education or information giving by nurses, this study places emphasis on the content of that information by taking the patients'perspective and asking the patients themselves what particular types of information are perceived as important at a specific point in time The aim of the study was to explore what particular types of information were important to women newly diagnosed with breast cancer, to enable nurses and other health care professionals to utilize their time as effectively as possible and provide a high-quality service to individuals in their care Women with breast cancer (a mean of 2 5 weeks from diagnosis) were interviewed and asked to compare items of information The items of information were presented m pairs and the women stated a preference for one item in that pan- Thirty-six pairs were presented in total The analysis involved the use of a Thurstone scaling model, which allowed rank ordermgs, or profiles of information needs, to be developed, reflecting the perceived importance of each item Information about the likelihood of cure, the spread of the disease and treatment options were perceived as the most important items of information at the tune of diagnosis Other information needs, in order of descending priority, included information about the risk to family, side-effects 相似文献
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Splenic T cells from myelin basic protein (MBP)-immunised Lewis rats were activated to transfer experimental autoimmune encephalomyelitis (EAE) by co-culture with MBP-pulsed lymphoid dendritic cells (DC). MBP-pulsed DC could be kept for at least 24 h at 37 degrees C in antigen-free medium without affecting their ability subsequently to activate encephalitogenic T cells. However, MBP-pulsed DC were rendered much less stimulatory after a 6 h, but not 2 h, secondary incubation with ovalbumin. Thus, although encephalitogenic complexes between MBP and DC appear very stable in the absence of competing antigens, in their presence, antigen exchange can take place over a period of a few hours; this has positive implications for therapy of EAE by antigen competition. 相似文献
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To investigate whether the secular trend for growth in Dutch children still exists, the Oosterwolde I study of 1980 was repeated in 1989. A persisting secular trend was visible for height while the z scores of body proportions show no change during the past 10 years, which suggests that there is no change in the timing of puberty. 相似文献
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Michael Leonard Uthman Alao Aaron Glynn Mark Dolan 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2009,19(8):553-558
Between 1999 and 2005, we treated 41 patients with a total hip arthroplasty for failed fixation of a hip fracture. This study
had three purposes: (1) to determine the reason/s for fixation failure (2) to record difficulties/complications encountered
in converting to a salvage arthroplasty and (3) to compare the outcome of these patients (Group 1) with a matched group of
patients who underwent a primary hip arthroplasty (Group 2). Failure to achieve a good reduction and optimal screw placement
was evident in 80% of cases of failed fixation. A high incidence of complications was recorded in the perioperative period
during conversion to a salvage arthroplasty. Functional outcome was statistically inferior in Group1; this group also had
a higher incidence of complications. Radiographs at 2 years postoperatively showed evidence of femoral stem loosening in 16%
of the salvage group compared with 3% in the primary hip arthroplasty group. 相似文献