全文获取类型
收费全文 | 1078篇 |
免费 | 69篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 40篇 |
妇产科学 | 9篇 |
基础医学 | 112篇 |
口腔科学 | 21篇 |
临床医学 | 93篇 |
内科学 | 210篇 |
皮肤病学 | 78篇 |
神经病学 | 66篇 |
特种医学 | 243篇 |
外科学 | 77篇 |
综合类 | 3篇 |
预防医学 | 69篇 |
眼科学 | 13篇 |
药学 | 34篇 |
肿瘤学 | 80篇 |
出版年
2022年 | 8篇 |
2021年 | 10篇 |
2020年 | 7篇 |
2019年 | 7篇 |
2018年 | 18篇 |
2017年 | 18篇 |
2016年 | 14篇 |
2015年 | 12篇 |
2014年 | 23篇 |
2013年 | 28篇 |
2012年 | 31篇 |
2011年 | 26篇 |
2010年 | 19篇 |
2009年 | 16篇 |
2008年 | 32篇 |
2007年 | 46篇 |
2006年 | 40篇 |
2005年 | 38篇 |
2004年 | 35篇 |
2003年 | 38篇 |
2002年 | 45篇 |
2001年 | 37篇 |
2000年 | 29篇 |
1999年 | 26篇 |
1998年 | 34篇 |
1997年 | 28篇 |
1996年 | 26篇 |
1995年 | 17篇 |
1994年 | 31篇 |
1993年 | 20篇 |
1992年 | 12篇 |
1991年 | 15篇 |
1990年 | 22篇 |
1989年 | 41篇 |
1988年 | 29篇 |
1987年 | 38篇 |
1986年 | 31篇 |
1985年 | 23篇 |
1984年 | 25篇 |
1983年 | 16篇 |
1982年 | 16篇 |
1981年 | 21篇 |
1980年 | 16篇 |
1979年 | 8篇 |
1978年 | 12篇 |
1977年 | 8篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1974年 | 15篇 |
1970年 | 9篇 |
排序方式: 共有1153条查询结果,搜索用时 0 毫秒
1.
C. J. M. Antens M. Oldenwening A. Wolse U. Gehring H. A. Smit R. C. Aalberse M. Kerkhof J. Gerritsen J. C. de Jongste B. Brunekreef 《Clinical and experimental allergy》2006,36(12):1525-1531
BACKGROUND: Studies of the association between indoor allergen exposure and the development of allergic diseases have often measured allergen exposure at one point in time. OBJECTIVE: We investigated the variability of house dust mite (Der p 1, Der f 1) and cat (Fel d 1) allergen in Dutch homes over a period of 8 years. METHODS: Data were obtained in the Dutch PIAMA birth cohort study. Dust from the child's mattress, the parents' mattress and the living room floor was collected at four points in time, when the child was 3 months, 4, 6 and 8 years old. Dust samples were analysed for Der p 1, Der f 1 and Fel d 1 by sandwich enzyme immuno assay. RESULTS: Mite allergen concentrations for the child's mattress, the parents' mattress and the living room floor were moderately correlated between time-points. Agreement was better for cat allergen. For Der p 1 and Der f 1 on the child's mattress, the within-home variance was close to or smaller than the between-home variance in most cases. For Fel d 1, the within-home variance was almost always smaller than the between-home variance. Results were similar for allergen levels expressed per gram of dust and allergen levels expressed per square metre of the sampled surface. Variance ratios were smaller when samples were taken at shorter time intervals than at longer time intervals. CONCLUSION: Over a period of 4 years, mite and cat allergens measured in house dust are sufficiently stable to use single measurements with confidence in epidemiological studies. The within-home variance was larger when samples were taken 8 years apart so that over such long periods, repetition of sampling is recommended. 相似文献
2.
3.
4.
5.
Simone Postma Henk Schers Tom van de Belt Kees van Boven Huib ten Napel Hugo Stappers Debby Gerritsen Tim Olde Hartman 《Health expectations》2022,25(4):1363
BackgroundIn primary care, a shift from a disease‐oriented approach for patients with multimorbidity towards a more person‐centred approach is needed.AimTo transform a self‐report questionnaire for patients with chronic conditions in primary care, the Primary Care Functioning Scale (PCFS), into an understandable, visually attractive and feasible consultation tool for patients and health care providers. The consultation tool consists of a web‐based version of the PCFS, which is filled in by the patient and is processed to a feedback report that summarizes and visualizes the main findings. The feedback report can be discussed with the patient to facilitate a more person‐centred conversation for patients with chronic conditions and multimorbidity in general practice.Design and SettingIn this qualitative study, we developed the consultation tool by using design thinking in a participatory developmental process.MethodsIn the first phase, we constructed five different feedback report templates to summarize and display the results of a completed PCFS questionnaire in a series of two expert meetings with patients and general practitioners (GPs). In the second phase, we performed an exploratory qualitative interview study involving dyads of patients with chronic conditions and their practice nurses. In an iterative process, we explored their experiences with the consultation tool.ResultsPatients, as well as GPs, preferred a clear manner of presenting the results of the questionnaire in a feedback report. In 18 interviews with patients and practice nurses during three different interview rounds, we adjusted the feedback report and consultation tool based on the input from patients and practice nurses. After the final interview round, patients and practice nurses consented that the consultation tool was useful for having a more in‐depth consultation about functioning and patients'' preferences when integrated into the regularly scheduled consultations.ConclusionWe were able to develop an understandable and feasible consultation tool that is applicable in already existing chronic disease management programmes in general practice in the Netherlands.Patient or Public ContributionTo increase the understandability and feasibility of the consultation tool, we collaborated with end‐users and actively involved patients, GPs and practice nurses in a participatory development process. 相似文献
6.
7.
8.
9.
10.
Branching out: a molecular fingerprint of endothelial differentiation into tube-like structures generated by Affymetrix oligonucleotide arrays 总被引:3,自引:0,他引:3
Gerritsen ME Soriano R Yang S Zlot C Ingle G Toy K Williams PM 《Microcirculation (New York, N.Y. : 1994)》2003,10(1):63-81
The process of endothelial differentiation into a network of tube-like structures with patent lumens requires an integrated program of gene expression. To identify genes upregulated in endothelial cells during the process of tube formation, RNA was prepared from several different time points (0, 4, 8, 24, 40, and 48 hours) and from three different experimental models of human endothelial tube formation: in collagen gels and fibrin gels driven by the combination of PMA (80), bFGF (40 ng/ml) and bFGF (40 ng/ml) or in collagen gels driven by the combination of HGF (40 ng/ml) and VEGF (40 ng/ml). Gene expression was evaluated using Affymetrix Gene Chip oligonucleotide arrays. Over 1000 common genes were upregulated greater than twofold over baseline at one or more time points in the three different models. In the present study, we discuss the identified genes that could be assigned to major functional classes: apoptosis, cytoskeleton, proteases, matrix, and matrix turnover, pumps and transporters, membrane lipid turnover, and junctional molecules or adhesion proteins. 相似文献