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排序方式: 共有332条查询结果,搜索用时 31 毫秒
1.
Plasma pharmacokinetics of high-dose oral busulfan in children and adults undergoing bone marrow transplantation 总被引:2,自引:0,他引:2
Bruce Bostrom Karen Enockson Amy Johnson Alyssa Bruns Bruce Blazar 《Pediatric transplantation》2003,7(S3):12-18
Abstract: We have analyzed the plasma pharmacokinetics of busulfan in 272 patients receiving high-dose oral busulfan and intravenous cyclophosphamide in conjunction with allogeneic or autologous bone marrow transplantation. The patients ranged in age from 2 months to 59 yr (mean 10, median 12 yr) and had the following diagnoses: thalassemia or sickle cell anemia (n = 74); leukemia or myelodysplasia (n = 112); inborn errors of metabolism (n = 41) or immunodeficiency (n = 45). Plasma specimens were collected following the first dose for each patient which ranged from 1 to 4 mg/kg (mean ± SD, 1.21 ± 0.41, median 1.15). Busulfan was quantitated using ultraviolet absorbance detection after derivatization and HPLC separation. Pharmacokinetic parameters were derived by modeling the raw data to fit first-order single compartment kinetics. The kinetic parameters showed wide interpatient variability independent of age and diagnosis. There was a statistically significant correlation of age with the following parameters: area under the curve (AUC); maximal concentration; minimum concentration; clearance; volume of distribution and absorption half-time. The coefficients of determination (i.e. correlation coefficient squared) were low ranging from 0.04 to 0.12 implying only a small part (i.e. 4–12%) of the variance was explained by age. Although busulfan pharmacokinetics are age-related most of the variability is not explained by age or diagnosis. 相似文献
2.
Improved rapid methods for the determination of iron content and binding capacity of serum 总被引:3,自引:2,他引:3 下载免费PDF全文
Improved methods are described for the determination of serum iron (SeFe) and latent iron-binding capacity under controlled conditions of pH. As before, no precipitation or heating of the serum is required, and controls are not used. Unbuffered sulphonated bathophenanthroline is employed for colour development. Statistical data for 40 normals are presented and comparisons with other data are given; the effects of ageing of serum are studied. 相似文献
3.
Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice
4.
Bostrom AC Brenner PS Griffiths JL Johnson MM Volkman T West CR 《The Michigan nurse》1999,72(7):12-6; quiz 17-9
5.
Tolo ET Bostrom MP Simic PM Lyden JP Cornell CM Thorngren KG 《International orthopaedics》1999,23(5):279-282
A prospective outcome study was performed of 100 hip fracture patients at an urban medical center in the United States. After
hospitalization 19% were discharged to a rehabilitation facility and 59% were discharged home. At a mean follow-up of 8 months,
81% of patients lived at home, compared to 89% who lived at home prior to the fracture. At follow-up 71% of the patients were
able to walk outside with one cane or no aids at all, and 81% were able to perform basic activities of daily living. Half
of all patients did not require any home assistance at follow-up. Ten patients had died at follow-up. The goal of operatively
treating the patient with a hip fracture is fixation of the fracture with a return to the patient’s pre-fracture functional
ability. This study illustrates that patients with hip fractures can be effectively treated and discharged home or to a short-term
rehabilitation facility with restoration of their pre-fracture functional status.
Accepted: 8 August 1999 相似文献
Résumé Une étude prospective sur le devenir de 100 patients présentant une fracture de la hanche a été faite dans un Centre Médical Urbain des USA. Après l’hospitalisation, 19% des patients sont allés en structure de rééducation et 59% ont regagné leur domicile. A un délai moyen de 8 mois, 81% des patients vivent à domicile alors qu’il y en avait 89% avant la fracture. Au délai d’observation, 71% des patients marchent à l’extérieur avec une canne ou sans aide et 81% sont capables des activités habituelles de la vie quotidienne. La moitié des patients n’ont besoin d’aucune assistance à domicile. 10 patients sont morts. Le but du traitement opératoire des patients présentant une fracture de la hanche est la fixation de la fracture pour permettre un retour au niveau de fonction pré-traumatique. Cette étude confirma la possibilité d’un retour à l’état fonctionnel antérieur avec, aprés le traitement, un retour à domicile ou un court séjour en Centre de réadaptation.
Accepted: 8 August 1999 相似文献
6.
N A Heerema J B Nachman H N Sather M K La R Hutchinson B J Lange B Bostrom P G Steinherz P S Gaynon F M Uckun 《Leukemia》2004,18(5):939-947
Monosomy 7 or deletions of 7q are associated with many myeloid disorders; however, the significance of such abnormalities in childhood acute lymphoblastic leukemia (ALL) is unknown. Among 1880 children with ALL, 75 (4%) had losses involving chromosome 7, 16 (21%) with monosomy 7, 41 (55%) with losses of 7p (del(7p)), 16 (21%) with losses of 7q (del(7q)), and two (3%) with losses involving both arms. Patients with losses involving chromosome 7 were more likely to be > or =10 years old, National Cancer Institute (NCI) poor risk, and hypodiploid than patients lacking this abnormality. Patients with or without these abnormalities had similar early response to induction therapy. Event-free survival (EFS) and survival for patients with monosomy 7 (P<0.0001 and P=0.0007, respectively) or del(7p) (P<0.0001 and P=0.0001, respectively), but not of patients with del(7q), were significantly worse than those of patients lacking these abnormalities. The poorer EFS was maintained after adjustment for a Philadelphia (Ph) chromosome, NCI risk status, ploidy, or an abnormal 9p. However, the impact on survival was not maintained for monosomy 7 after adjustment for a Ph. These results indicate that the critical region of loss of chromosome 7 in pediatric ALL may be on the p-arm. 相似文献
7.
PURPOSE: To determine the correlation of central corneal thickness (CCT) to Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT, PASCAL), and to glaucoma stage as assessed by cup-to-disc ratio (CDR). DESIGN: Prospective, cross-sectional tricenter observation study. PATIENTS AND METHODS: From three glaucoma specialty practices a sample of 406 independent eyes was included. After ultrasound pachymetry, intraocular pressure was measured using PASCAL and Goldmann applanation tonometry and cup-to-disc ration was reassessed. Demographic data were included in the multivariate analysis. RESULTS: Mean corneal thickness was 540 microm. African Americans and normal-tension glaucoma patients showed the lowest values (518 microm and 522 microm, respectively). These values were significantly thinner than the central corneal thickness of Caucasians (549 microm) and ocular hypertensives (564 microm). Intraocular pressure assessed by Goldmann applanation tonometry shows a significant correlation with central corneal thickness (r = 0.068, P < 0.001), whereas PASCAL is not significantly associated with central corneal thickness (r < 0.001, P = 0.997). Increased IOP is significantly correlated with large ocular pulse amplitudes (r = 0.13, P < 0.001), which is predominantly seen in ocular hypertensives. A significant negative correlation was detected between cup-to-disc ratio and central corneal thickness (r = 0.102, P < 0.001). CONCLUSION: Glaucoma patients with thin central corneal thickness are more likely to be found at an advanced stage of the disease and among those with normal-tension glaucoma and black African ancestry. Underestimation of intraocular pressure by Goldmann applanation tonometry could be one causative factor. 相似文献
8.
Ekstrand K.; Bostrom P. A; Lilja B.; Hansen O.; Arborelius M. Jr 《European heart journal》1997,18(5):822-834
Clinical and ergometric data were derived from 1098 consecutiveexercise tests in patients with a first acute myocardial infarctionbetween 19741983. In 1992 a follow-up was performed inorder to analyse the importance of a submaximal early exercisetest, in combination with clinical data, for the predictionof short- and long-term prognosis of cardiovascular death. The relative value of 20 clinical variables, including medicalhistory, markers of infarction size, medication etc., and 28variables at exercise test were studied. Univariate, multivariateand survival analysis, for estimation of prognosis and independentprediction of cardiovascular death was used. Independent clinical risk factors for cardiovascular death were(1) Within 1 year: relative heart volume (ml.m2 bodysurface area) on chest X-ray. (2) Long-term mortality: maximumheart rate and relative heart volume, diabetes, age and digitalismedication. Independent exercise risk factors were: (1) Within1 year: heart rate, ventricular arrhythmia and ST depression 1 mm before exercise, diastolic blood pressure at maximum exerciseand target heart rate. (2) Long-term mortality: angina pectorisand/or ST depression 1 mm at maximum exercise. In subgroupsof patients with clinical risk factors, mortality risk increasedif there were signs of angina pectoris and/or ST depression 1 mm during exercise. The risk increased 100% in diabetics,91% with age >70 years, 58% with relative heart volume 500ml.m2 body surface area, 42% with heart rate 100 atadmission, and 34% with digitalis medication. No increase wasfound in the subgroup of patients without clinical risk factors. Thus, submaximal early exercise stress testing provides importantinformation for short- and long-term prognosis in patients afterthe first acute myocardial infarction compared to clinical evaluationalone. 相似文献
9.
Beverly J Lange Bruce C Bostrom Joel M Cherlow Martha G Sensel Mei K L La Wayne Rackoff Nyla A Heerema Robert S Wimmer Michael E Trigg Harland N Sather 《Blood》2002,99(3):825-833
Addition of a delayed-intensification (DI) phase after standard induction/consolidation therapy was previously shown to improve outcome for patients younger than 10 years of age with intermediate-risk acute lymphoblastic leukemia (ALL). The current trial randomized 1204 patients to regimens containing a single DI phase (405 patients), 2 DI phases (DDI) (402 patients), or a single DI phase in conjunction with increased vincristine and prednisone pulses during maintenance (DIVPI) (397 patients). Estimates of event-free survival (EFS) and survival at 6 years are 79% +/- 1% and 89% +/- 1%, respectively. EFS was improved on DDI compared with either DI (log-rank P =.04; Kaplan-Meier [KM] P =.04; relative risk [RR] = 1.38) or DIVPI (log-rank P =.04; KM P =.01; RR = 1.39).There was no difference in EFS for the DI and DIVPI regimens (log-rank P =.96; KM P =.75). Survival estimates at 6 years were 87% (SD = 2%) for DI; 91% (SD = 2%) for DDI; and 90% (SD = 2%) for DIVPI (P =.17). Significant univariate risk factors for the overall cohort included poor day-7 marrow response, black race, and age of at least 5 years. These data demonstrate that DDI improves EFS of patients younger than 10 years of age with intermediate-risk ALL. 相似文献
10.
Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone 下载免费PDF全文
Matthew J. Grosso Hayden‐William Courtland Xu Yang James P. Sutherland Kirsten Stoner Joseph Nguyen Anna Fahlgren F. Patrick Ross Marjolein C. H. van der Meulen Mathias P. Bostrom 《Journal of orthopaedic research》2015,33(2):163-173