收费全文 | 32404篇 |
免费 | 3001篇 |
国内免费 | 39篇 |
耳鼻咽喉 | 315篇 |
儿科学 | 958篇 |
妇产科学 | 805篇 |
基础医学 | 3966篇 |
口腔科学 | 516篇 |
临床医学 | 3603篇 |
内科学 | 6631篇 |
皮肤病学 | 535篇 |
神经病学 | 3008篇 |
特种医学 | 1032篇 |
外国民族医学 | 3篇 |
外科学 | 4510篇 |
综合类 | 653篇 |
一般理论 | 49篇 |
预防医学 | 3829篇 |
眼科学 | 527篇 |
药学 | 1992篇 |
中国医学 | 34篇 |
肿瘤学 | 2478篇 |
2023年 | 219篇 |
2022年 | 333篇 |
2021年 | 786篇 |
2020年 | 441篇 |
2019年 | 768篇 |
2018年 | 866篇 |
2017年 | 614篇 |
2016年 | 613篇 |
2015年 | 699篇 |
2014年 | 960篇 |
2013年 | 1366篇 |
2012年 | 1933篇 |
2011年 | 1923篇 |
2010年 | 1098篇 |
2009年 | 1000篇 |
2008年 | 1635篇 |
2007年 | 1714篇 |
2006年 | 1662篇 |
2005年 | 1635篇 |
2004年 | 1490篇 |
2003年 | 1380篇 |
2002年 | 1201篇 |
2001年 | 720篇 |
2000年 | 729篇 |
1999年 | 675篇 |
1998年 | 367篇 |
1997年 | 269篇 |
1996年 | 279篇 |
1995年 | 268篇 |
1994年 | 224篇 |
1993年 | 215篇 |
1992年 | 489篇 |
1991年 | 473篇 |
1990年 | 429篇 |
1989年 | 438篇 |
1988年 | 382篇 |
1987年 | 369篇 |
1986年 | 338篇 |
1985年 | 348篇 |
1984年 | 285篇 |
1983年 | 255篇 |
1982年 | 190篇 |
1979年 | 265篇 |
1978年 | 197篇 |
1977年 | 173篇 |
1974年 | 185篇 |
1973年 | 228篇 |
1972年 | 210篇 |
1971年 | 172篇 |
1969年 | 171篇 |
Background
Partial nephrectomy (PN) is generally favored for cT1 tumors over radical nephrectomy (RN) when technically feasible. However, it can be unclear whether the additional risks of PN are worth the magnitude of renal function benefit.Objective
To develop preoperative tools to predict long-term estimated glomerular filtration rate (eGFR) beyond 30 d following PN and RN, separately.Design, setting, and participants
In this retrospective cohort study, patients who underwent RN or PN for a single nonmetastatic renal tumor between 1997 and 2014 at our institution were identified. Exclusion criteria were venous tumor thrombus and preoperative eGFR <15 ml/min/1.73 m2.Intervention
RN and PN.Outcome measurements and statistical analysis
Hierarchical generalized linear mixed-effect models with backward selection of candidate preoperative features were used to predict long-term eGFR following RN and PN, separately. Predictive ability was summarized using marginal , which ranges from 0 to 1, with higher values indicating increased predictive ability.Results and limitations
The analysis included 1152 patients (13 206 eGFR observations) who underwent RN and 1920 patients (18 652 eGFR observations) who underwent PN, with mean preoperative eGFRs of 66 ml/min/1.73 m2 (standard deviation [SD] = 18) and 72 ml/min/1.73 m2 (SD = 20), respectively. The model to predict eGFR after RN included age, diabetes, preoperative eGFR, preoperative proteinuria, tumor size, time from surgery, and an interaction between time from surgery and age (marginal ). The model to predict eGFR after PN included age, presence of a solitary kidney, diabetes, hypertension, preoperative eGFR, preoperative proteinuria, surgical approach, time from surgery, and interaction terms between time from surgery and age, diabetes, preoperative eGFR, and preoperative proteinuria (marginal ). Limitations include the lack of data on renal tumor complexity and the single-center design; generalizability needs to be confirmed in external cohorts.Conclusions
We developed preoperative tools to predict renal function outcomes following RN and PN. Pending validation, these tools should be helpful for patient counseling and clinical decision-making.Patient summary
We developed models to predict kidney function outcomes after partial and radical nephrectomy based on preoperative features. This should help clinicians during patient counseling and decision-making in the management of kidney tumors. 相似文献Methods: [11C]WAY100635, [18F]altanserin and positron emission tomography were used to compare 5-HT1A and 5-HT2A binding in MDD patients divided into eight past suicide attempters (>4yrs prior to scanning) and eight lifetime non-attempters, and both groups were compared to eight healthy volunteers.
Results: The two receptor types differed in binding pattern across brain regions from each other, but there were no differences in binding between healthy volunteers and the two depressed groups or between depressed suicide attempters and non-attempters. No effects of depression severity or lifetime aggression were observed for either receptor.
Conclusion: Limitations of this study include small sample size and absence of high lethality suicide attempts in the depressed attempter group. No trait-like binding correlations with past suicide attempt or current depression were observed. Given the heterogeneity of nonfatal suicidal behavior, a larger sample study emphasizing higher lethality suicide attempts may find the serotonin biological phenotype seen in suicide decedents. 相似文献