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M. S. BHATE P. E. ROBERTSON E. V. DAVISON J. A. BRUMMITT 《Journal of intellectual disability research : JIDR》1989,33(3):235-244
ABSTRACT. A case of Prader Willi Syndrome who suffered from hypothyroidism is described. This patient on cytogenetic examination was found to have Mosaic 46,XX/46,XX,det(15Kq11.1q11.2) karyotype. 相似文献
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A. TSATSOULIS E. WHITEHEAD J. ST. JOHN S. M. SHALET W. R. ROBERTSON 《Clinical endocrinology》1987,27(6):683-689
Eighteen men (mean age 27, range 18-30 years) treated for Hodgkin's disease with 6-8 courses of MVPP (Mustine, Vinblastine, Procarbazine and Prednisolone) have had Leydig cell function assessed by their steroidogenic responses to stimulation by a single bolus dose of HCG (1000 units intramuscularly). Normal age-matched men (n = 16) acted as controls. Baseline immunoreactive FSH was markedly raised in the patients (mean 18.1 +/- SD 6.9 vs 2.0 +/- 1.5 IU/l, P less than 0.0001) reflecting damage to the germinal epithelium. Immunoreactive LH was also greater in patients (10.3 +/- 3.9 IU/l) than in controls (3.9 +/- 1.9 IU/l, P less than 0.0001). There were no differences between the baseline testosterone, androstenedione, oestradiol, oestrone and sex hormone binding globulin (SHBG) concentrations. The testosterone/SHBG ratios were similar in the two groups and there was no correlation between baseline LH and testosterone concentrations or testosterone/SHBG ratios. Testosterone, androstenedione, oestradiol and oestrone secretion in response to HCG stimulation were similar at 24 h and 96 h in both groups. In order to explain the paradox of elevated immunoreactive LH in the face of normal testicular steroidogenesis in such patients, LH biological activity (B) as well as LH immunoreactivity (I) and FSH and testosterone were estimated in a second similar group of patients (n = 17, mean age 27, range 17-43 years) and in a further age-matched control group (n = 17). Bioactive and immunoreactive LH levels were significantly increased (P less than 0.005 and P less than 0.001, respectively) in the patient group.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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ROBERTSON RF 《British medical journal》1948,2(4589):1059-1061
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JIS ROBERTSON 《Nephrology (Carlton, Vic.)》1996,2(S1):s66-s71
Summary: Despite numerous deficiencies in some antihypertensive drug treatment trials, and some questionable selections of studies for inclusion in several meta-analyses, undoubtedly such trials have shown treatment benefits from reducing hypertension. Complications that can be corrected or prevented include malignant hypertension, hypertensive heart failure, stroke and coronary artery morbidity. the all-cause mortality has been lowered in several trials. the benefits have been seen in subjects aged over 60 years, in women and men, and in patients with isolated systolic hypertension. the benefits have been achieved using a wide range of drugs, not only with beta-blockers or diuretics. Non-pharmacological means of lowering blood pressure have not been evaluated in relation to morbidity. 相似文献
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THE [LACTATE]/[PYRUVATE] RATIO AND ALCOHOL METABOLISM: EXPERIMENTS WITH NALOXONE IN FASTING NORMAL MALE VOLUNTEERS 总被引:2,自引:1,他引:1
MORGAN CHRISTOPHER J.; BADAWY ABDULLA A.-B.; THOMAS D. ROGER; DANDO TIM G.; KIRBY AMANDA 《Alcohol and alcoholism (Oxford, Oxfordshire)》1989,24(3):185-188
Naloxone administration to fasting normal male volunteers reversesthe acute ethanol-induced increase in the blood [lactate]/[pyruvate]ratio, but fails to lower blood-ethanol concentration. The resultsare discussed in relation to factors affecting ethanol eliminationand the mechanism of antagonism of acute alcohol intoxicationby naloxone. 相似文献
10.
THE IMPACT OF ALCOHOL ON THE ACUTE HOSPITAL SERVICE: PATIENT PRESENTATION, ADMISSION AND THE PERCEPTION OF ALCOHOL USE IN SUCH GROUPS 总被引:1,自引:0,他引:1
ROBERTSON C. E.; LITTLE K.; SMITH H.; RITSON E. B. 《Alcohol and alcoholism (Oxford, Oxfordshire)》1989,24(5):405-408
Patients presenting to an Emergency Department were assessedby a standard questionnaire and clinical examination as to thecontribution that alcohol made to their presentation and theperception of their alcohol use. Patients under the influenceof alcohol are more than twice as likely not to fill in simplequestionnaires and not to perceive their alcohol consumptionas different from non-drinking fellows. Emergency Departmentsare not the optimal site for the education and motivation ofdrinking patients to alter their future habits. 相似文献