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Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors 总被引:1,自引:0,他引:1
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Tetè S Zara S Zizzari VL De Carlo A Vinci R Cataldi A Gherlone E 《Clinical oral implants research》2012,23(11):1254-1260
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This study was conducted to assess the knowledge of H1N1 among medical students, their perceptions, and behavioral intentions in the wake of the H1N1 pandemic influenza. There were significant gaps in important self-isolation protocols and preventive measures. Increased contact with both patients and colleagues can lead to unintentional transmission and contraction of influenza. Universities should introduce and encourage infection control guidelines into routine curriculum. 相似文献
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Associate Professor Skye McDonald Robyn Tate Leanne Togher Michael Perdices Anne Moseley Kiri Winders 《Aphasiology》2013,27(7):676-683
Background: Clinicians face significant obstacles in their access to evidence for the efficacy of different communicative and cognitive treatments after brain impairment. These include the need to search across diverse journals and different clinical conditions to find potential treatments and the lack of easily accessible standards by which to evaluate the methodological rigour of treatment studies once found. Aims: We aimed to address these issues by developing a freely available, user‐friendly database of all relevant treatment trials for psychologically based disorders that arise from brain impairment. Methods & Procedures: PsycBITETM (http://www.psycbite.com) was developed as an internet‐based database and was officially launched in 2004. Included on PsycBITETM are all trials that have been published that evaluate treatment for any communication, cognitive, or psychological disorder arising from any form of acquired brain impairment in children (above the age of 5 years) and adults. PsycBITETM also provides a rating for the methodological rigour of each trial using the previously established PEDro scale (Maher, Sherrington, Herbert, Moseley, & Elkins, 2003) for randomised controlled trials (RCT) and non‐RCT group comparisons. A PsycBITETM rating scale for single case experimental studies is still under development. This report overviews the database, its contents, and the methodology by which papers are selected for inclusion. Outcomes & Results: As of June 2005 there are 1167 treatment studies listed on PsycBITETM with prospective searches being conducted on a regular basis. The highest proportion of studies report treatments for communication disorders followed by behavioural problems and memory. Ratings of the randomised controlled trials, group comparisons, and single case studies are available for a proportion of papers and are being updated continuously. Conclusions: PsycBITETM is an invaluable resource for clinicians and researchers interested in an evidence‐based practice approach to treatment. It is a free, fast, and effective way of accessing and evaluating treatments for communicative and cognitive disorders following brain impairment. 相似文献
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Leanne Togher 《Aphasiology》2013,27(4):365-390
This study is one of a series investigating everyday communication skills of people with traumatic brain injury (TBI) using communication partners other than speech pathologists or research assistants. The first of these studies examined telephone conversations where subjects were asked to request specific information during telephone interactions with a range of communication partners. Results indicated that people with TBI were disadvantaged in some of their interactions on the telephone with community agencies and family members during information-seeking interactions, when compared with matched controls. TBI subjects were given less information than matched controls and were also asked for less information. For example, therapists never asked TBI subjects questions to which they didn't already know the answer. This was in contrast to the control interactions, where subjects were asked for novel information. In the current study seven subjects with TBI were compared with seven matched control subjects across two conditions: a community education information-giving session with two schoolboys, and an information-requesting interaction with the researcher. Exchange structure analysis showed that when placed in an information-giving role, TBI subjects gave similar amounts of information as control subjects. TBI subjects used joke telling as an information-giving device, serving a number of communicative functions, which are discussed. There was no significant difference in the amount of information requested or given by TBI and control subjects in the researcher condition; however there were significant qualitative differences in the nature of the requesting. It has been previously emphasized that people with TBI should be evaluated with a number of interlocutors as part of a thorough communication needs assessment (Hartley 1995). Merely varying the interlocutor is not sufficient, however, as the goal of the interaction and the primary speaking roles of participants are also important, and will determine the language choices available to both speakers. Exchange structure analysis is a useful way to delineate these language choices, as it is interpreted in light of the genre of the interaction and the tenor and communicative purpose of the participants. 相似文献
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Training communication partners of people with traumatic brain injury: A randomised controlled trial
Background: Communication disorders after traumatic brain injury (TBI) are difficult to modify due to the cognitive limitation imposed by frontal lobe damage. As an alternative approach, this paper describes a training programme designed to improve communication partners' responsiveness to people with TBI during routine service inquiries with a community agency. Aims: To evaluate the effectiveness of a training programme aimed at improving the communication of police officers during service encounters with people with TBI. Methods & Procedures: A total of 20 police officers were randomly assigned to two groups (training or control). Prior to the 6‐week training programme, participants with TBI made a routine telephone inquiry to the police officers. Training focused on specific aspects of telephone inquiries previously documented to be aberrant in service encounters of people with TBI. Following the training programme, police subjects received another telephone service inquiry. Service encounters were transcribed and analysed using generic structure potential analysis. Outcome & Results: Comparison of pre‐ and post‐training measures indicated that trained police had learned strategies to successfully establish the nature of the inquiry, provide a clear answer to the inquiry, and ensure appropriate leave taking, resulting in more efficient, focused interactions in the post‐training telephone calls. People with TBI also altered their communication in the post‐training calls, with reduced episodes of unrelated utterances and an increased proportion of the interaction devoted to completing the service encounter. This appeared to be in response to the communicative options they were given. Conclusions: This study demonstrates the efficacy of an approach based on training communication partners rather than people with TBI themselves. Training communication partners led to the provision of appropriate feedback, support, and structure of everyday interactions. Service encounters account for a significant amount of everyday communication exchanges, therefore training service providers has the potential to have a significant impact on the communicative effectiveness of people with TBI. 相似文献
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Background: Considerable attention has been given to the nature of communication impairments of individuals with TBI (Coelho, 2007; Ylvisaker, Turkstra, & Coelho, 2005). However, there have been few data focusing on the way communication partners deal with the often distressing sequelae of TBI. Aims: This study reports inter- and intra-rater reliability of the Adapted Measure of Support in Conversation (MSC) and Measure of Participation in Conversation (MPC) for TBI interactions. Method & Procedures: The MSC and MPC were adapted to reflect theoretical models of cognitive-communication support for people with TBI. A total of 10 casual and 10 purposeful TBI interactions were independently rated by two raters to establish inter-rater reliability and by one rater on two separate occasions to determine intra-rater reliability. Outcomes & Results: Excellent inter-rater agreement was established on the MSC (ICC?=?0.85–0.97) and the MPC (ICC?=?0.84–0.89). Intra-rater agreement was also strong (MSC: ICC?=?0.80–0.90; MPC: ICC?=?0.81–0.92). Over 90% of all ratings scored within 0.5 on a 9-point scale. Conclusions: This is the first scale to measure the communication partner during TBI interactions. It shows promise in evaluating communication partner training programmes. 相似文献
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