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Martin Jonczyk Julius Chapiro Federico Collettini Dominik Geisel Dirk Schnapauff Florian Streitparth Thomas Schmidt Bernd Hamm Bernhard Gebauer Gero Wieners 《Journal of vascular and interventional radiology : JVIR》2017,28(10):1378-1385
Purpose
To evaluate detectability of hepatocellular carcinoma (HCC) using split-bolus cone-beam CT in intraindividual comparison between cone-beam CT and contrast-enhanced MR imaging.Materials and Methods
In a retrospective, single-center study, 28 patients with 85 HCC tumors were treated with transarterial chemoembolization between May 2015 and June 2016. All patients underwent arterial and hepatobiliary phase (HBP) MR imaging within 1 month before transarterial chemoembolization. Cone-beam CT images were acquired using a split-bolus contrast injection with 2 contrast injections and 1 cone-beam CT acquisition. Statistical analyses included Friedman 2-way analysis, Kendall coefficient of concordance, and Wilcoxon test. Tumor detectability was scored using a 5-point system (1 = best; 5 = worst) by 2 independent readers resulting in 170 evaluated tumors. Quantitative analysis included signal-to-noise and contrast-to-noise ratio and contrast measurements. P values < .05 were considered significant.Results
Better tumor detection was provided with split-bolus cone-beam CT (2.91/2.73) and HBP MR imaging (2.93/2.21) compared with arterial MR imaging (3.72/3.05; P < .001) without statistical difference between cone-beam CT and HBP MR imaging in terms of detectability (P = .154) and sensitivity for hypervascularized tumors. More tumors were identified on cone-beam CT (n = 121/170) than on arterial MR imaging (n = 94/170). Average contrast-to-noise ratio values of arterial and HBP MR imaging were higher than for cone-beam CT (7.79, 8.58, 4.43), whereas contrast values were higher for cone-beam CT than for MR imaging (0.11, 0.13, 0.97).Conclusions
Split-bolus cone-beam CT showed excellent detectability of HCC. Sensitivity is comparable to HBP MR imaging and better than arterial phase MR imaging. 相似文献2.
Collettini Federico Schreiber Nadja Schnapauff Dirk Denecke Timm Wust Peter Schott Eckart Hamm Bernd Gebauer Bernhard 《Strahlentherapie und Onkologie》2015,191(5):405-412
Strahlentherapie und Onkologie - The purpose of the present study was to evaluate the clinical outcome of CT-guided high-dose-rate brachytherapy (CT-HDRBT) in patients with unresectable... 相似文献
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Dirk Schnapauff MD Elke Zimmermann MD Marc Dewey MD 《Seminars in Ultrasound, CT and MRI》2008,29(3):167-175
Coronary computed tomography angiography is an emerging imaging technique that has attracted much scientific attention over the past years. Improved scanner technology and dedicated protocols have made noninvasive coronary a reliable diagnostic test in patients with suspected coronary artery disease (CAD). Several technical steps such as the introduction of 64-slice scanners, multisegment reconstruction, and dual-source computed tomography have substantially improved temporal and spatial resolution. With these sophistications, coronary computed tomography angiography enables reliable exclusion of CAD in patients with low to intermediate pretest probability of having CAD or with inconsistent ischemia test results. 相似文献
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Dirk Schnapauff MD Martin Zeile MD Manuel Ben Niederhagen MD Barbara Fleige MD Per‐Ulf Tunn MD Bernd Hamm MD Oliver Dudeck MD 《Journal of magnetic resonance imaging : JMRI》2009,29(6):1355-1359
Purpose
To investigate the eligibility of diffusion‐weighted imaging (DWI) for the evaluation of tumor cellularity in patients with soft‐tissue sarcomas.Materials and Methods
Thirty consecutive patients with a total of 31 histologically‐proven soft‐tissue sarcomas prospectively underwent magnetic resonance imaging (MRI) including DWI with echo‐planar imaging (EPI) technique immediately before open biopsy (N = 1) or tumor resection (N = 30). Fourteen patients had no previous anticancer treatment, 16 had received neoadjuvant therapy. Tumor cellularity as determined from histological sections was compared with minimum apparent diffusion coefficient (ADC).Results
Tumor cellularity correlated well with minimum ADC in a linear fashion, with a Pearson correlation coefficient of –0.88 (95% confidence interval [CI]: –0.75 to –0.96). This relationship was not influenced by prior anticancer treatment. There was only a tendency toward lower ADC in tumor with higher grading but no significant dependency (P = 0.08).Conclusion
DWI has proven useful for the assessment of tumor cellularity in soft‐tissue sarcomas. In result, DWI may be used as a powerful noninvasive tool to monitor responses of cytotoxic treatment as reflected by changes in tumor cellularity. J. Magn. Reson. Imaging 2009. © 2009 Wiley‐Liss, Inc. 相似文献7.
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Jan Holger Rothe Christian Grieser Lukas Lehmkuhl Dirk Schnapauff Carmen Perez Fernandez Martin H. Maurer Axel Mussler Bernd Hamm Timm Denecke Ingo G. Steffen 《European journal of radiology》2013