全文获取类型
收费全文 | 3242篇 |
免费 | 236篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 74篇 |
儿科学 | 61篇 |
妇产科学 | 77篇 |
基础医学 | 494篇 |
口腔科学 | 45篇 |
临床医学 | 283篇 |
内科学 | 763篇 |
皮肤病学 | 46篇 |
神经病学 | 248篇 |
特种医学 | 214篇 |
外科学 | 428篇 |
综合类 | 104篇 |
一般理论 | 2篇 |
预防医学 | 150篇 |
眼科学 | 26篇 |
药学 | 304篇 |
中国医学 | 8篇 |
肿瘤学 | 182篇 |
出版年
2023年 | 21篇 |
2022年 | 57篇 |
2021年 | 107篇 |
2020年 | 49篇 |
2019年 | 63篇 |
2018年 | 86篇 |
2017年 | 67篇 |
2016年 | 72篇 |
2015年 | 76篇 |
2014年 | 115篇 |
2013年 | 170篇 |
2012年 | 261篇 |
2011年 | 284篇 |
2010年 | 157篇 |
2009年 | 115篇 |
2008年 | 206篇 |
2007年 | 212篇 |
2006年 | 213篇 |
2005年 | 165篇 |
2004年 | 179篇 |
2003年 | 154篇 |
2002年 | 144篇 |
2001年 | 36篇 |
2000年 | 37篇 |
1999年 | 37篇 |
1998年 | 22篇 |
1997年 | 27篇 |
1996年 | 22篇 |
1995年 | 19篇 |
1994年 | 8篇 |
1993年 | 9篇 |
1992年 | 24篇 |
1991年 | 22篇 |
1990年 | 17篇 |
1989年 | 16篇 |
1988年 | 14篇 |
1987年 | 17篇 |
1986年 | 17篇 |
1985年 | 27篇 |
1984年 | 13篇 |
1983年 | 17篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 13篇 |
1978年 | 8篇 |
1976年 | 9篇 |
1975年 | 12篇 |
1974年 | 11篇 |
1973年 | 10篇 |
1972年 | 7篇 |
排序方式: 共有3509条查询结果,搜索用时 0 毫秒
1.
2.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献3.
Leif Ivar Havelin Nils Roar Gjerdet Ole Dankert Lunde Milan Rait Einar Sudmann 《Acta orthopaedica》1986,57(5):419-422
The wear was examined in 39 Christiansen total hip prostheses, which were removed because of mechanical loosening after being used 5 (3-11) years. In the polyacetal acetabular cups, the head had made an eccentric defect, the mean volume of which was 680 (180-3310) mm3. The mean penetration of the head into the wall of the cup was 0.8 (0.1-3.2) mm. In two additional cups the head had penetrated right through the wall of the cup. In three prostheses the polyacetal sleeve of the trunnion was so worn that the head bore directly on the stem. There was a positive correlation between wear and the time the prostheses had been used before symptoms of loosening presented. 相似文献
4.
H Schroeder C R Pinkerton R L Powles S T Meller D Tait S Milan T J McElwain 《Bone marrow transplantation》1991,7(1):11-15
High dose melphalan (HDM 110-140 mg/m2) and total body irradiation (TBI, 10.5 Gy, single fraction) followed by infusion of autologous bone marrow (ABMT) was evaluated for toxicity and efficacy in 24 children with acute lymphoblastic leukaemia (ALL) in second (CR2) or third remission (CR3). Marrow was purged with Campath 1 in six children (four were children in CR3). All children had engraftment with a median of 30 days (range 18-70 days) to neutrophil count greater than 0.5 x 10(9)/l. Four children (16%) died from toxicity 1-4 months after autograft, two from pneumonitis, one from an intracerebral haemorrhage and one from sepsis. Apart from fever and mucositis the procedure was well tolerated. Nine of 17 children treated in CR2 remain in complete remission 6-72 months after ABMT (median 25 months). Seven of these have a follow-up of greater than 12 months. Three of the seven children treated in CR3 are alive 17, 22 and 29 months post ABMT. Seven children relapsed within 10 months (median 4 months) of the autograft. Only one relapse has occurred beyond 10 months. HDM and TBI followed by ABMT is a relatively well tolerated regimen and may contribute to survival in children with relapsed ALL. 相似文献
5.
6.
Ultrasonography in the detection of cervical incompetency 总被引:2,自引:0,他引:2
Mario Podobnik Milan Buli Nikola Smiljanic Josip Bistri
ki 《Journal of clinical ultrasound : JCU》1988,16(6):383-391
In 80 pregnancies with clinical and ultrasonic signs of cervical incompetency, the length of the cervix and the thickness of the anterior wall of a lower uterine segment have been evaluated ultrasonically. We have also measured the width of the endocervical canal and studied the prolapse of fetal membranes (with fetal parts) into the endocervical canal. We evaluated these same parameters in 80 healthy pregnancies. The length of the cervix, the thickness of the anterior wall of a lower uterine segment, and the width of the endocervical canal were followed longitudinally in the patients from the 10th to the 36th gestation week. No statistically significant differences between age groups were found. In four age groups at risk for cervical incompetency, cervical lengths and wall thickness were significantly different (p less than 0.001) from those in comparable controls. Forty-five percent of the patients in the at-risk group, with cervical cerclage, delivered at 37.3 (range: 32 to 41) weeks and 6.25% of pregnancies ended in abortion when the amniotic membrane herniated into the cervical canal, with or without some part of the fetus. 相似文献
7.
Daniel Jirák Jan Kríz Vít Herynek Benita Andersson Peter Girman Martin Burian Frantisek Saudek Milan Hájek 《Magnetic resonance in medicine》2004,52(6):1228-1233
A promising treatment method for type 1 diabetes mellitus is transplantation of pancreatic islets containing beta-cells. The aim of this study was to develop an MR technique to monitor the distribution and fate of transplanted pancreatic islets in an animal model. Twenty-five hundred purified and magnetically labeled islets were transplanted through the portal vein into the liver of experimental rats. The animals were scanned using a MR 4.7-T scanner. The labeled pancreatic islets were clearly visualized in the liver in both diabetic and healthy rats as hypointense areas on T2*-weighted MR images during the entire measurement period. Transmission electron microscopy confirmed the presence of iron-oxide nanoparticles inside the cells of the pancreatic islets. A significant decrease in blood glucose levels in diabetic rats was observed; normal glycemia was reached 1 week after transplantation. This study, therefore, represents a promising step toward possible clinical application in human medicine. 相似文献
8.
Michael C Graves Milan Fiala Lu Anne V Dinglasan Nancy Q Liu James Sayre Francesco Chiappelli Cees van Kooten Harry V Vinters 《Amyotrophic lateral sclerosis and other motor neuron disorders》2004,5(4):213-219
Recent studies have shown inflammatory markers in affected neural tissues of amyotrophic lateral sclerosis (ALS) patients. We examined immunocytochemically spinal cord tissues of six patients with ALS, two with corticospinal tract degeneration secondary to cerebral infarcts and three control subjects without neuropathologic abnormalities. ALS spinal cords had dense macrophage infiltration (one log greater than control spinal cords) involving the white and gray matter, with heaviest infiltration of lateral and ventral columns and, in one patient, prefrontal gyrus and the occipital lobes of the brain. Macrophages in ALS spinal cord showed strong expression of cyclooxygenase-2 (COX-2) (one log greater than control tissues) and inducible nitric oxide synthase. In the gray matter, macrophages surrounded and appeared to phagocytize neurons (NeuN-positive) that appeared to be dying. Vessels showed damage to the tight junction protein ZO-1 in relation to perivascular CD40 receptor-positive macrophages and CD40 ligand-positive T lymphocytes. ALS spinal cords, but not control cords, were sparsely infiltrated with mast cells. In control cases with corticospinal tract degeneration following hemispheric cerebral infarction, macrophage infiltration of the white matter was COX-2-negative and restricted to lateral and anterior corticospinal tracts. Our data suggest that inflammation in ALS spinal cord and cortex is based on innate immune responses by macrophages and mast cells and adaptive immune responses by T cells. 相似文献
9.
Multiple myeloma: epidemiological features in a well-defined population in Burgundy, France 总被引:1,自引:0,他引:1
P M Carli F Bailly C Tavernier C Milan D Heudes J F Lavault 《International journal of epidemiology》1989,18(2):330-333
Epidemiological features of multiple myeloma were studied over a seven-year period (1980-86) in the department of C?te d'Or (population 478,000). The crude annual incidence rates were 3.7/100,000 for males and 4.0/100,000 for females. The corresponding age-standardized rates were 2.5 and 2.1. The sex ratio was 1.2. Cumulative rates were 0.3% for both sexes. Age and specific incidence were low before 50 and increased with advancing age up to 85 years in males and females. There was no significant variation in incidence over the seven-year period. The risk of multiple myeloma was slightly higher in urban than in rural areas (the variations were not significant). The period between the beginning of the symptoms and the diagnosis was often short, less than one month in 56% of the cases. When compared to other population based registries the incidence rates are similar to those reported all over the world (except for registries with a high proportion of blacks in the population). Cases have been staged according to Durie and Salmon classification: 32% of the cases were classified as Stage I. This result suggests that globally cases diagnosed in a well-defined population are less severe than those reported in hospital statistics. Survival showed significant differences: there were better rates for patients under 75 and for patients at stage I and II compared with stage III patients. Percentage and morphology of plasma cells also influenced prognosis. 相似文献
10.
Limb reduction defects in Emilia Romagna, Italy: epidemiological and genetic study in 173,109 consecutive births. 总被引:1,自引:1,他引:1 下载免费PDF全文
E Calzolari D Manservigi G P Garani G Cocchi C Magnani M Milan 《Journal of medical genetics》1990,27(6):353-357
Epidemiological and genetic variables in limb reduction defects (LRD) were analysed during the years 1978 to 1987 in a case control study in Emilia Romagna, northern Italy. During the observation period, 83 neonates out of 173,109 consecutive births had LRD (4.8 per 10,000). Cases were divided into five subgroups: transverse, intercalary, longitudinal, split, and multiple types of LRD. Of all cases, 64% were upper limb, 21% lower limb, and 15% both. Coexisting non-limb malformations were found in 10 cases (12%), five with recognised syndromes and five with other associated defects. About 7.2% of first degree relatives had defects involving the skeletal system. In two cases the mother had the same type of LRD (a split). No recurrence among sibs was observed. Risk factors correlated with LRD were found to be low birth weight (2500 g or less), vaginal bleeding, and threatened abortion. 相似文献