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排序方式: 共有167条查询结果,搜索用时 8 毫秒
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Gyuranecz M Dénes B Hornok S Kovács P Horváth G Jurkovich V Varga T Hajtós I Szabó R Magyar T Vass N Hofmann-Lehmann R Erdélyi K Bhide M Dán A 《Vector borne and zoonotic diseases (Larchmont, N.Y.)》2012,12(8):650-653
Abstract Q fever is an important zoonotic disease caused by Coxiella burnetii. There are few reliable data about C. burnetii infection available. The aim of this study was to assess the importance and potential infectious sources of Q fever in Hungary. A total of 215 milk samples (10 individual samples from each herd and 1 bulk tank milk sample from each cattle herd), and 400 serum samples (20 from each herd) were tested from 15 dairy cattle herds and 5 sheep flocks located in different parts of Hungary. The study found 19.3% (58/300) and 38.0% (57/150) seropositivity in cattle, and 0% (0/100) and 6.0% (3/50) seropositivity in sheep, by complement fixation test (CFT) and enzyme-linked immunosorbent assay (ELISA), respectively. C. burnetii DNA was detected by IS1111 element-based TaqMan real-time polymerase chain reaction (PCR) in 8.7% (13/150) of individual dairy cow milk samples, 4.0% (2/50) of individual sheep milk samples, and 66.7% (10/15) of dairy bulk tank milk samples. Samples taken from nine different commercially-available pasteurized cow milk products from different Hungarian producers were also tested for the presence of C. burnetii DNA, and eight of these samples were found to be positive (88.9%). The real-time PCR examination of 5402 ixodid ticks collected from different parts of the country yielded negative results. Knowledge of the true prevalence of Q fever is crucial for policymakers involved in evidence-based decision making. 相似文献
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Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens 总被引:13,自引:0,他引:13
Injectable biodegradable polymeric particles (usually microspheres) represent an exciting approach to control the release of vaccine antigens to reduce the number of doses in the immunization schedule and optimize the desired immune response via selective targeting of antigen to antigen presenting cells. After the first couple of decades of their study, much progress has been made towards the clinical use of antigen-loaded microspheres. Poly(lactide-co-glycolic acids) (PLGAs) have been studied most commonly for this purpose because of their proven safety record and established use in marketed products for controlled delivery of several peptide drugs. PLGA microspheres have many desirable features relative to standard aluminum-based adjuvants, including the microspheres' ability to induce cell-mediated immunity, a necessary requirement for emergent vaccines against HIV and cancer. This review examines several impediments to PLGA microparticle development, such as PLGA-encapsulated antigen instability and deficiency of animal models in predicting human response, and describes new trends in overcoming these important issues. PLGA microparticles have displayed unprecedented versatility and safety to accomplish release of one or multiple antigens of varying physical-chemical characteristics and immunologic requirements, and have now met numerous critical benchmarks in development of long-lasting immunity after a single injected dose. 相似文献
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Badwe RA Thorat MA Parmar VV 《The New England journal of medicine》2003,349(20):1968-71; author reply 1968-71
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Gupta PC Saxena S Pednekar MS Maulik PK 《Alcohol and alcoholism (Oxford, Oxfordshire)》2003,38(4):327-331
AIMS: To assess the prevalence and pattern of alcohol use in a middle-aged and elderly population in Mumbai, India. METHODS: 50 220 men aged >/=45 years from the lower and lower-middle section of the general population were interviewed. RESULTS: 18.8% were currently consuming alcoholic beverages, of whom 32.8% drank on at least 6 days per week. The most popular beverage was locally distilled products of fruits and grain (country liquor). Seventy-five per cent of the consumers of country liquor would consume over 53 g of ethanol on a day when they drank, with 46.6% of these doing so on at least 6 days per week. CONCLUSIONS: Abstinence, and also heavy and frequent use of alcohol, are common in this population and the latter is likely to have significant public health implications. 相似文献