全文获取类型
收费全文 | 56248篇 |
免费 | 4835篇 |
国内免费 | 1714篇 |
专业分类
耳鼻咽喉 | 522篇 |
儿科学 | 1151篇 |
妇产科学 | 1233篇 |
基础医学 | 6061篇 |
口腔科学 | 1127篇 |
临床医学 | 6928篇 |
内科学 | 11024篇 |
皮肤病学 | 1082篇 |
神经病学 | 3297篇 |
特种医学 | 1259篇 |
外国民族医学 | 6篇 |
外科学 | 6216篇 |
综合类 | 6188篇 |
现状与发展 | 2篇 |
一般理论 | 9篇 |
预防医学 | 4866篇 |
眼科学 | 1283篇 |
药学 | 5002篇 |
53篇 | |
中国医学 | 2295篇 |
肿瘤学 | 3193篇 |
出版年
2024年 | 167篇 |
2023年 | 716篇 |
2022年 | 1697篇 |
2021年 | 2696篇 |
2020年 | 1909篇 |
2019年 | 1819篇 |
2018年 | 2052篇 |
2017年 | 1856篇 |
2016年 | 1612篇 |
2015年 | 2297篇 |
2014年 | 2990篇 |
2013年 | 3498篇 |
2012年 | 5058篇 |
2011年 | 5118篇 |
2010年 | 3486篇 |
2009年 | 3041篇 |
2008年 | 3673篇 |
2007年 | 3586篇 |
2006年 | 3113篇 |
2005年 | 2835篇 |
2004年 | 2218篇 |
2003年 | 2071篇 |
2002年 | 1684篇 |
2001年 | 468篇 |
2000年 | 376篇 |
1999年 | 328篇 |
1998年 | 296篇 |
1997年 | 276篇 |
1996年 | 244篇 |
1995年 | 191篇 |
1994年 | 157篇 |
1993年 | 126篇 |
1992年 | 109篇 |
1991年 | 75篇 |
1990年 | 84篇 |
1989年 | 75篇 |
1988年 | 67篇 |
1987年 | 59篇 |
1986年 | 56篇 |
1985年 | 58篇 |
1984年 | 49篇 |
1983年 | 44篇 |
1982年 | 61篇 |
1981年 | 67篇 |
1980年 | 38篇 |
1979年 | 40篇 |
1978年 | 22篇 |
1977年 | 34篇 |
1976年 | 31篇 |
1975年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
María Cabrerizo Gloria Trallero María José Pena Amaia Cilla Gregoria Megias Carmen Mu?oz-Almagro Eva Del Amo Diana Roda Ana Isabel Mensalvas Antonio Moreno-Docón Juan García-Costa Nuria Rabella Manuel Ome?aca María Pilar Romero Sara Sanbonmatsu-Gámez Mercedes Pérez-Ruiz María José Santos-Mu?oz Cristina Calvo And the study group of “Enterovirus parechovirus infections in children under ?years-old Spain” PI- 《European journal of pediatrics》2015,174(11):1511-1516
2.
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells 总被引:65,自引:10,他引:55
PADGEM protein (PADGEM), also known as GMP140, is a platelet alpha- granule membrane protein that is translocated to the external membrane after platelet activation. Although the biosynthesis of this protein was originally thought to be confined to megakaryocytes, the synthesis of PADGEM in endothelial cells was recently demonstrated (McEver et al: Blood 70:1974a, 1987). We now describe the subcellular localization of this protein in endothelial cells. Immunofluorescence staining of permeabilized human umbilical vein endothelial cells with KC4, a well characterized monoclonal antibody to PADGEM, showed positively stained elongated structures similar in distribution and shape to Weibel-Palade bodies. Their identity as Weibel-Palade bodies was confirmed by double label immunofluorescence using KC4 and a polyclonal antiserum to von Willebrand factor (vWf), a protein known to be specifically stored in these organelles. All Weibel-Palade bodies were found to contain PADGEM. In contrast to strong perinuclear staining produced with anti- vWf antibodies, no significant perinuclear staining was obtained with KC4, indicating that relatively little PADGEM is present in the endoplasmic reticulum and in the Golgi apparatus. In endothelial cells treated with secretagogues that stimulate vWf release the elongated structures positive for PADGEM disappeared, further identifying these structures as Weibel-Palade bodies. This observation extends the parallels between Weibel-Palade bodies and alpha-granules and suggests a possible functional association between vWf and PADGEM. 相似文献
3.
R. San Juan M. Yebra C. Lumbreras F. López-Medrano M. Lizasoain J.C. Meneu J. Delgado A. Andrés J.M. Aguado 《Clinical transplantation》2009,23(5):666-671
Abstract: Long-term prophylaxis against cytomegalovirus (CMV) started immediately after transplantation in (D+/R−) poses a higher risk of late-onset CMV disease. Delayed CMV prophylaxis could allow a transitory exposure of the immune system to CMV, which would let the immune system mount an adequate CMV-specific cytotoxic response in (D+/R−) patients and confer protection against CMV disease. We included all (D+/R−) solid organ transplant recipients (SOT) performed at our institution (January 3/October 6) who received CMV prophylaxis (mainly with oral valganciclovir) during 100 d. In the first period (until December 4), prophylaxis was initiated immediately after transplantation (conventional prophylaxis: CP). Since January 5, it was initiated after 14 d (delayed prophylaxis: DP). Incidence and severity of CMV disease was compared between both groups. A total of 44 SOT recipients were included (CP: 26 and DP: 18). CMV disease was diagnosed in eight patients (18%), seven of 26 (27%) in the CP group, and one of 18 (5.5%) in the DP group (p = 0.07). CMV colitis was reported in five of 26 patients in the CP group (19%), whereas there were no cases of visceral CMV disease in the DP group (p = 0.048). A 14-d delay in the beginning of long-term prophylaxis against CMV in (D+/R−) is safe and could prevent the onset of late-CMV disease. 相似文献
4.
100例性病患者心理健康状况调查分析 总被引:3,自引:1,他引:2
目的:探讨性病患者的心理健康状况,为临床治疗和护理提供依据。方法:采用症状自评量表(SCL-90)对100例性病患者的心理健康状况进行测验。结果:100例性病患者SCL-90检测的阳性率为51%,阳性样本因子分居前的是敌对、强迫症状、抑郁、人际敏感。结论:性病患者广泛存在的心理问题,在药用治疗的同时应注意心理方面的治疗和疏导。 相似文献
5.
膀胱肿瘤2350例临床病理学特点分析 总被引:1,自引:0,他引:1
目的 探讨膀胱肿瘤的发病现状、总体趋势和病理特点.方法 整理1980-2007年2350例膀胱肿瘤病理档案,分为1980-1989、1990-1999和2000-2007年3个时间段.应用SPSS 13.0软件分析3时间段患者性别、年龄及肿瘤组织学类型间的关系.结果 2350例膀胱肿瘤中男1854例,女496例.良性92例,恶性2258例,膀胱恶性肿瘤的发病人数逐年上升.发病高峰年龄从50~69岁推迟到60~79岁.1980-1989、1990-1999和2000-2007年3个时间段中男、女恶性肿瘤病例数分别为524例和113例(4.64:11 00)、589例和164例(3.59:1.00)、675例和193例(3.50:1.00),男性约为女性的3.80倍;3时间段男性发生膀胱尿路上皮癌年龄分别为(57.5±11.7)、(62.6±12.3)、(65.9±11.3)岁,女性分别为(58.7±13.6)、(60.7±12.1)、(65.8±12.0)岁,男女各年龄段分别比较差异有统计学意义(P<0.05).男性发生鳞状细胞癌、尿路上皮癌和腺癌年龄分别为(68.05±9.7)、(59.85±14.1)、(63.4±9.9)岁,差异有统计学意义(P相似文献
6.
This column contains the presidential address presented during the Third Annual Meeting of the American Association of Heart Failure Nurses on June 28, 2007, in San Diego, California, titled "Building the Foundation of Excellence in Heart Failure Nursing." 相似文献
7.
8.
9.
10.