全文获取类型
收费全文 | 18731篇 |
免费 | 849篇 |
国内免费 | 87篇 |
专业分类
耳鼻咽喉 | 124篇 |
儿科学 | 254篇 |
妇产科学 | 178篇 |
基础医学 | 2263篇 |
口腔科学 | 418篇 |
临床医学 | 1115篇 |
内科学 | 4206篇 |
皮肤病学 | 1153篇 |
神经病学 | 1848篇 |
特种医学 | 769篇 |
外科学 | 3058篇 |
综合类 | 109篇 |
预防医学 | 584篇 |
眼科学 | 215篇 |
药学 | 1703篇 |
中国医学 | 39篇 |
肿瘤学 | 1631篇 |
出版年
2022年 | 159篇 |
2021年 | 313篇 |
2020年 | 178篇 |
2019年 | 213篇 |
2018年 | 303篇 |
2017年 | 238篇 |
2016年 | 320篇 |
2015年 | 336篇 |
2014年 | 431篇 |
2013年 | 489篇 |
2012年 | 771篇 |
2011年 | 823篇 |
2010年 | 476篇 |
2009年 | 403篇 |
2008年 | 794篇 |
2007年 | 835篇 |
2006年 | 826篇 |
2005年 | 808篇 |
2004年 | 846篇 |
2003年 | 848篇 |
2002年 | 817篇 |
2001年 | 620篇 |
2000年 | 696篇 |
1999年 | 668篇 |
1998年 | 296篇 |
1997年 | 216篇 |
1996年 | 214篇 |
1995年 | 188篇 |
1994年 | 143篇 |
1993年 | 126篇 |
1992年 | 468篇 |
1991年 | 422篇 |
1990年 | 426篇 |
1989年 | 453篇 |
1988年 | 430篇 |
1987年 | 383篇 |
1986年 | 337篇 |
1985年 | 306篇 |
1984年 | 195篇 |
1983年 | 170篇 |
1982年 | 107篇 |
1981年 | 84篇 |
1979年 | 181篇 |
1978年 | 107篇 |
1977年 | 101篇 |
1975年 | 85篇 |
1974年 | 87篇 |
1973年 | 89篇 |
1972年 | 90篇 |
1970年 | 85篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Kengo Maeda Shinji Kume Yoshihiko Nishio Shiro Maeda Yasuhiro Nishida Mikio Suzuki Takahiro Nakaguchi Toru Kawabata Osamu Hashimoto Takashi Hisanaga Atsunori Kashiwagi Hitoshi Yasuda 《Clinical neurology》2006,46(4):266-269
We report a 53-year-old woman with severe Graves' ophthalmopathy accompanied by uncontrolled myasthenia gravis. She presented remarkable exophthalmos, chemosis, and restriction of eye movement. Despite plasma exchange, steroid pulse therapy, local injection of steroid, and irradiation, ocular symptoms did not ameliorate. Since optic neuropathy was seen, orbital decompression surgery was performed in the left eye. Bilateral chemosis was improved after the surgery. Five years after surgery, there was no ocular palsy in the operated left eye, but in the contralateral eye. For the good prognosis of the eye movement, orbital decompression might be recommended in the severe Graves' ophthalmopathy accompanied by the optic neuropathy and/or ophthalmoplegia with proptosis. 相似文献
3.
Kanji Takeo Eric Virtudazo Misako Ohkusu Susumu Kawamoto Shoko Ito-Kuwa Sigeji Aoki 《Nippon Ishinkin Gakkai Zasshi》2006,47(4):257-262
In Cryptococcus neoformans the DNA content of cells having tiny buds varied rather widely, depending on growth phases and strains used. Typically, buds of C. neoformans emerged soon after initiation of DNA synthesis in the early exponential phase. However, bud emergence was delayed to G2 during transition to the stationary phase, and in the early stationary phase budding scarcely occurred, although roughly half of the cells completed DNA synthesis. The timing of budding in C. neoformans was shifted to later cell cycle points with progression of the growth phase of the culture. Similarly, a deficit in oxygen was demonstrated to delay the timing of budding, prolong the G2 phase and cause accumulation of cells after DNA synthesis, but before commitment to budding. The C. neoformans homologue of the main cell cycle control gene CDC28/Cdc2 was isolated using degenerate RT-PCR. The full-length coding region was then amplified using primers to target the regions around the start and stop codons. The gene was called CnCdk1 and was found to have high homologies to S. cerevisiae CDC28 and S. pombe cdc2. To determine its function, its ability to rescue S. cerevisiae cdc28-temperature sensitive mutants was tested. S. cerevisiae cdc28-4 and cdc28-1N strains transformed with the pYES2-CnCdk1 construct exhibited growth at the restrictive temperature. Results of the sequence analysis and the ability of CnCdk1 to complement the S. cerevisiae cdc28-ts mutations support its assumed role as the CDC28/cdc2 homologue in C. neoformans. 相似文献
4.
5.
M Yoshino Y Sakaguchi N Kuriya Y Ohtani F Yamashita T Hashimoto K Oyanagi K Tada K Narisawa T Kitagawa 《Neuropediatrics》1991,22(4):198-202
A nationwide survey of transient hyperammonemia in newborns was carried out in Japan. A total of 18 patients, consisting of 12 male and 6 female infants, were reported from 11 facilities. These neonates exhibited hyperammonemia with plasma ammonia levels in the range from 124 to 6256 micrograms/dl. Four newborn infants of the 18 died in the neonatal period, and an additional one died in the early infancy. Among the 13 infants who were alive at the time of this survey, 6 had neurological sequelae, including mental retardation, spastic quadriplegia and epilepsy. The multivariate analysis revealed that the Apgar score at 1 minute, peak plasma ammonia concentration, birth weight and sex were significant factors affecting the prognosis of life. 相似文献
6.
7.
8.
Tanaka Takeo Kobayashi Masao Saito Osamu Kamada Nanao Kuramoto Atsushi Usui Tomofusa 《Clinica chimica acta; international journal of clinical chemistry》1981,117(2):121-131
The biochemical activities of 8 lysosomal acid hydrolases in leukemic cells from 48 patients were examined. Characteristic alterations were found in α-mannosidase, β-galactosidase and N-acetyl-β-glucosaminidase activities of leukemic cells. The level of α-mannosidase activity was much higher in myelo(mono)genous leukemias (AML, AMoL, AMMoL, CML and CMMoL) than in lymphogenous ones (ALL, T-cell leukemia, hairy cell leukemia and CLL) without exception. The β-galactosidase activity also differed as a result of α-mannosidase, except in T-cell leukemia. In T-cell leukemia it was within the range of normal lymphocytes, but in the other lymphogenous leukemias it was significantly below normal. N-acetyl-β-glucosaminidase activity in myelo(mono)genous leukemic cells was above the range of normal granulocytes. The changes in these enzyme levels were consistent. The lymphocytic or myelocytic nature of three cases of acute undifferentiated leukemia could be determined by enzyme studies. In two cases it was lymphocytic and in one it was myelocytic. The enzymatic abnormalities were also found in morphologically mature neutrophils from patients with not only chronic types (CML, CMMoL) but also acute types (AMoL, AMMoL) of leukemias, and were similar to those of their respective leukemic cells. Analysis of lysosomal enzymes (at least three of those mentioned above), can elucidate one of the biochemical properties of leukemic cells and may be valuable in the differentiation of leukemias. 相似文献
9.
S Watanabe K Nakano H Misumi M Yoshikai M Endo A Hashimoto H Koyanagi 《Nihon Geka Gakkai zasshi》1989,90(9):1513-1516
St. Jude Medical valve replacement was performed in 1,039 patients; 320 had aortic (AVR), 543 mitral (MVR), and 176 had double valve replacement (DVR). There were 44(4.2%) early deaths. Follow-up extended in 995 patients from 10 to 130 months, with a cumulative period of 2,730 patients-years. The overall survival rates of AVR, MVR, and DVR patients at 10 years were 60.5%, 89.6%, 90.3% respectively. The linearized incidences of valve thrombosis, thromboembolism, anticoagulation-related hemorrhage, prosthetic valve endocarditis, and significant hemolysis were as follows: 0.11%/pt-yr, 1.33%/pt-yr, 0.04%/pt-yr, 0.18%/pt-yr, and 0.11%/pt-yr, respectively. There were no structural failure after 10 years follow-up. Reoperation (explant and re-replacement or suture repair) was required in 10 patients. Seven of them had periprosthetic leakage, 2 had valve thrombosis, and one underwent reoperation because of a technical error. Actuarially over 98% of patients were free of valve-related mortality at 10 years. St. Jude Medical valve is an excellent alternative for use in the surgical treatment of valvular heart disease. 相似文献
10.