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Andreia-Cristina Soare Viorica Meltzer Claudiu Colbea Ioana Stanculescu Elena Pincu 《Materials》2022,15(3)
Formulations with two or more active pharmaceutical ingredients (APIs) are a researched trend due to their convenient use compared with multiple medications. Moreover, drug-drug combinations may have a synergistic effect. Drotaverine hydrochloride (D-HCl) is commonly used for its antispasmodic action. The combination of a spasmolytic and an analgesic drug such as ibuprofen (Ibu) or ketoprofen (Ket) could become the answer for the treatment of localized pain. D-HCl:Ibu and D-HCl:Ket drug-drug interactions leading to the formation of eutectic compositions with increased bioavailability, obtained by mechanosynthesis, a green, solvent-free method was explored for the first time. The compatibility of Ibuprofen, Ketoprofen, and Drotaverine Hydrochloride was investigated using differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier-Transform Infrared spectroscopy (FTIR). Solid-liquid equilibrium (SLE) phase diagrams for the binary systems of active pharmaceutical ingredients were developed and the Tammann diagrams were designed to determine the eutectic compositions. The excess thermodynamic functions GE for the pre-, post-, and eutectic compositions were obtained using the computed activity coefficients data. Results show that drotaverine-based pharmaceutical forms for pain treatment may be obtained at 0.9 respectively 0.8 molar fractions of ibuprofen and ketoprofen which is advantageous because the maximum allowed daily dose of Ibu is about 6 times higher than those of D-HCl and Ket. The obtained eutectics may be a viable option for the treatment of pain associated with cancer therapy. 相似文献
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Intellectual development in shunted hydrocephalic children 总被引:4,自引:0,他引:4
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Erin C. Dunn Sc.D. M.P.H. Anna Wiste M.D. Ph.D. Farid Radmanesh M.D. M.P.H. Lynn M. Almli Ph.D. Stephanie M. Gogarten Ph.D. Tamar Sofer Ph.D. Jessica D. Faul Ph.D. Sharon L. R. Kardia Ph.D. Jennifer A. Smith Ph.D. David R. Weir Ph.D. Wei Zhao Ph.D. Thomas W. Soare Ph.D. Saira S. Mirza M.D. M.Sc. Karin Hek Ph.D. Henning Tiemeier M.D. Ph.D. M.A. Joseph S. Goveas M.D. Gloria E. Sarto M.D. Ph.D. Beverly M. Snively Ph.D. Marilyn Cornelis Ph.D. Karestan C. Koenen Ph.D. Peter Kraft Ph.D. Shaun Purcell Ph.D. Kerry J. Ressler M.D. Ph.D. Jonathan Rosand M.D. MSc Sylvia Wassertheil-Smoller Ph.D. Jordan W. Smoller M.D. Sc.D. 《Depression and anxiety》2016,33(4):265-280
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Harrington L Soare RI 《Proceedings of the National Academy of Sciences of the United States of America》1991,88(22):10242-10246
A set A of nonnegative integers is recursively enumerable (r.e.) if A can be computably listed. It is shown that there is a first-order property, Q(X), definable in E, the lattice of r.e. sets under inclusion, such that (i) if A is any r.e. set satisfying Q(A) then A is nonrecursive and Turing incomplete and (ii) there exists an r.e. set A satisfying Q(A). This resolves a long open question stemming from Post's program of 1944, and it sheds light on the fundamental problem of the relationship between the algebraic structure of an r.e. set A and the (Turing) degree of information that A encodes. 相似文献
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Diana Elena Vizitiu Daniela Ionela Sardarescu Irina Fierascu Radu Claudiu Fierascu Liliana Cristina Soare Camelia Ungureanu Elena Cocuta Buciumeanu Ionela Catalina Guta Letitia Mariana Pandelea 《Materials》2022,15(22)
Starting from the well-known antimicrobial properties of silver nanoparticles, the goal of this study is to evaluate the influence of two “green” recipes, namely an alcoholic extract of Dryopteris filix-mas (L.) Schott and a dispersion of silver nanoparticles phytosynthesized using the extract on grapevine pathogens. The influence of some grapevine parameters (pith/wood rapport, soluble sugars, starch, total sugars, total water content, length of young shoots, number of grapes) in field experiments was also studied. The study was conducted on four clones (Feteasca alba 97 St., Feteasca neagra 6 St., Feteasca regala 72 St., and Cabernet Sauvignon 131 St.) located in vegetation pots inside a greenhouse. For the phytosynthesis of the silver nanoparticles (AgNPs) we used a scaled-up technology, allowing us to obtain large quantities of nanoparticles-containing solution. The AgNPs analysis by X-ray diffraction and transmission electron microscopy confirmed the synthesis of spherical and quasi-spherical nanoparticles of 17 nm average diameter and 6.72 nm crystallite size. The field experiments registered different responses of the four clones to the treatment, using both the natural extracts and phytosynthesized nanoparticles solution. Both recipes exhibited a protective effect against the Uncinula necator pathogen. For the treatment using phytosynthesized nanoparticles, significant increases in the pith/wood ratio for white wine clones (Feteasca alba 97 St. and Feteasca regala 72 St.) were observed. The biochemical analyses revealed other significant increases of soluble sugars (red wine clones—Feteasca neagra and Cabernet Sauvignon/second year), starch (Feteasca alba and Cabernet Sauvignon in 2021 for both clones), total sugars (Feteasca alba and Feteasca neagra in 2021 for both clones), and of total water content (Feteasca alba and Feteasca neagra in 2021 for both clones), respectively. The applied treatments also led to an increase of young shoots length and grape numbers for all clones as compared to the control (chemical pesticide), which would suggest a potential biostimulant effect of the recipes. 相似文献
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Exposure to childhood adversity and deficits in emotion recognition: results from a large,population‐based sample
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