全文获取类型
收费全文 | 970篇 |
免费 | 41篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 21篇 |
妇产科学 | 18篇 |
基础医学 | 157篇 |
口腔科学 | 76篇 |
临床医学 | 78篇 |
内科学 | 255篇 |
皮肤病学 | 10篇 |
神经病学 | 99篇 |
特种医学 | 72篇 |
外科学 | 88篇 |
综合类 | 14篇 |
预防医学 | 37篇 |
眼科学 | 3篇 |
药学 | 62篇 |
中国医学 | 3篇 |
肿瘤学 | 27篇 |
出版年
2022年 | 9篇 |
2021年 | 11篇 |
2020年 | 21篇 |
2019年 | 18篇 |
2018年 | 17篇 |
2017年 | 15篇 |
2016年 | 13篇 |
2015年 | 24篇 |
2014年 | 37篇 |
2013年 | 35篇 |
2012年 | 50篇 |
2011年 | 47篇 |
2010年 | 24篇 |
2009年 | 25篇 |
2008年 | 39篇 |
2007年 | 50篇 |
2006年 | 39篇 |
2005年 | 18篇 |
2004年 | 28篇 |
2003年 | 33篇 |
2002年 | 22篇 |
2001年 | 14篇 |
2000年 | 23篇 |
1999年 | 17篇 |
1998年 | 28篇 |
1997年 | 23篇 |
1996年 | 20篇 |
1995年 | 19篇 |
1994年 | 9篇 |
1993年 | 14篇 |
1992年 | 19篇 |
1991年 | 13篇 |
1990年 | 18篇 |
1989年 | 19篇 |
1988年 | 24篇 |
1987年 | 19篇 |
1986年 | 21篇 |
1985年 | 24篇 |
1984年 | 15篇 |
1983年 | 13篇 |
1982年 | 12篇 |
1981年 | 6篇 |
1980年 | 10篇 |
1979年 | 16篇 |
1978年 | 4篇 |
1977年 | 10篇 |
1976年 | 7篇 |
1975年 | 7篇 |
1974年 | 8篇 |
1973年 | 5篇 |
排序方式: 共有1025条查询结果,搜索用时 0 毫秒
1.
Hugo Maia Julio Casoy Tania Correia Luís Freitas Kleber Pimentel Célia Athayde Elsimar Coutinho 《Gynecological endocrinology》2006,22(10):547-551
OBJECTIVES: To determine whether aromatase expression in the eutopic endometrium and adenomyotic foci is affected by previous use of oral contraceptives containing gestodene, and to determine whether changes in cyclooxygenase-2 (COX-2) expression occur in adenomyosis during the menstrual cycle. PATIENT AND METHODS: This was a retrospective cohort study carried out in paraffin-embedded endometrial tissue obtained from patients with a histological diagnosis of adenomyosis obtained during the proliferative (n = 25) and luteal (n = 10) phases of the menstrual cycle and following the use of continuous oral contraception with gestodene/ethinyl estradiol (n = 7). COX-2 and aromatase expression were measured in both eutopic endometrium and adenomyotic foci using immunohistochemical methods. RESULTS: Aromatase expression was detected in 80% of the endometrial slices by immunohistochemistry. In positive cases, aromatase was mainly detected in the stromal cells of the eutopic endometrium, whereas in the adenomyotic foci this expression was negative in the majority of the cases. Oral contraceptives containing gestodene, on the other hand, were effective in suppressing aromatase expression in both eutopic and ectopic endometrium. COX-2 expression was detected by immunohistochemistry in the glandular epithelium of both eutopic endometrium and adenomyotic foci and there were no significant changes in its intensity throughout the menstrual cycle. CONCLUSION: Aromatase expression in the eutopic endometrium and adenomyotic foci is suppressed by oral contraceptives containing gestodene. Increased aromatase activity may be responsible for the persistent COX-2 expression during the luteal phase. 相似文献
2.
Experimental results in female rats with marginal magnesium deficiency a and clinical results in over 100 female tetanic patients suggest the deleterious influence of magnesium on oro-facial tissues. 相似文献
3.
4.
B J Rounsaville T R Kosten H D Kleber 《The American journal of drug and alcohol abuse》1987,13(3):213-229
This report examines long-term and short-term benefits of achieving abstinence from opioids in a sample of opioid addicts who were reevaluated 2.5 years following seeking treatment. Extensive assessment of drug use history and drug-associated problems had been obtained when the subjects applied for treatment. At follow-up evaluations, detailed information was obtained on intervening course of drug use, treatment, legal problems, psychological problems, social functioning, occupational functioning, and medical status. The results were as follows: (1) Achieving abstinence from illicit opioids was associated with concurrent improvement in other aspects of functioning including reduction of criminal activity, improved medical status, improved social functioning, and reduced abuse of other psychoactive substances. However, many of these improvements were reversed immediately if relapse to opioid use occurred. (2) Achieving abstinence was associated with being in drug treatment, especially treatment in a methadone maintenance program. (3) Achievement of abstinence was not successfully predicted by client characteristics measured at entrance into treatment. (4) Long-range benefits of abstinence were detectable in social functioning even for those who had relapsed at the time of follow-up reevaluation. 相似文献
5.
6.
Parental and professional responses to questionnaires evaluating a paediatric disability service are reported and the viability of auditing structural, process, and outcome aspects of clinical practice are discussed. Expectations of waiting time to first appointment (met for only 52% of consumers) illustrate structural issues. Process issues are reflected in consumer reactions to outreach work (for example, 94% of parents and 84% of professionals found this supportive). Outcome measures such as consumer satisfaction with the service (76% of consumers reported being 'very satisfied' and 20% 'fairly satisfied') suggest that service aims are being met. Good concurrence of service aims with consumer needs is indicated by parental reasons for referral (for example, 75% for diagnostic help, 73% for a better understanding of the disorder, 88% for practical help), referrers' reasons (for example, 55% for a second diagnostic opinion, 45% due to lack of local expertise), and reports from most other professionals involved with the case that a similar service was not provided locally. 相似文献
7.
Serotyping of Serratia marcescens: evaluation of Le Minor's H-immobilization test and description of three new flagellar H antigens. 下载免费PDF全文
The H-immobilization test of Le Minor for determining flagellar (H) antigens was evaluated and compared with tube and slide H-agglutination tests. The test proved specific and easy to perform, and titration end points were clearly discernible. The degree of serological cross-reactivity between H antigen reference strains of Serratia marcescens was low. Consequently, this test was adopted for routine serological analysis of H antigens, using unabsorbed rabbit immune anti-H sera. As a result of using this procedure, three new provisional H antignes, designated H14, H15, and H16, are proposed. 相似文献
8.
Selective activation of classical and alternative pathways of human complement by "promptly serum-sensitive" and "delayed serum-sensitive" strains of Serratia marcescens. 下载免费PDF全文
Chelation of fresh human serum with 0.01 M MgCl2 (Mg) plus 0.01 M ethylene glycol tetraacetic acid failed to abrogate the bactericidal activity against "delayed serum-sensitive" strains of Serratia marcescens, whereas previously "promptly serum-sensitive" strains of S. marcescens and control strain Escherichia coli C were killed after an extended period of incubation. The addition of 0.01 M ethylenediametetracetate to fresh human serum neutralized bactericidal activity against S. marcescens of either serum sensitivity category. 相似文献
9.
Bruce J. Rousaville Myrna M. Weissman Patricia H. Rosenberger Charles H. Wilber Herbert D. Kleber 《Journal of affective disorders》1979,1(4):255-267
Previous investigators have reported a high prevalence of depressive symptoms in drug-dependent patients. Given the responsiveness of depressive disorders to both psychological and pharmacological treatments, it is desirable to find an economical, efficient screening instrument to detect depressive disorders in this population. In this study, 6 depression symptom screening scales (Beck Depression Inventory, Hamilton Depression Scale, Raskin Depression Scale, Degree of Illness Rating, Symptom Checklist 90 Overall, and Depression Subscale) based on either clinician interview or patient self report, were compared according to their utility in detecting cases of depression among 64 applicants for treatment at a substance abuse treatment unit of a community mental health center. The criteria for a case of depression were the Research Diagnostic Criteria (RDC) which are specified and operationalized. Cases identified using previously described cutoff scores on the screening scales were compared to rates based on the RDC and sensitivity and specificity were determined. The results showed that: (1) although the sensitivity of the symptom scales was applicable, ranging from 65--94%, the specificity was less impressive, ranging from 39--61%, and (2) the Beck Depression Inventory, a 13-item patient self report was the most sensitive and specific and is recommended for screening drug-dependent populations for depression. 相似文献
10.
Bilateral simultaneous tubal sextuplets: pregnancy after in-vitro fertilization--embryo transfer following salpingectomy 总被引:2,自引:1,他引:2
The presence of a damaged tube has been suggested in recent studies to have
a negative effect on in-vitro fertilization (IVF) outcome. Performing
bilateral salpingectomy prior to IVF to maximize pregnancy rates may also
result in unnecessary surgery. This case is also an example of the
occurrence of interstitial pregnancy after salpingectomy. This unusual type
of ectopic pregnancy must be kept in mind when evaluating a patient
suspected of a possible early abnormal gestation after assisted
reproductive technolologies.
相似文献