排序方式: 共有32条查询结果,搜索用时 140 毫秒
1.
R. L. O’Gorman S.-S. Poil D. Brandeis P. Klaver S. Bollmann C. Ghisleni R. Lüchinger E. Martin A. Shankaranarayanan D. C. Alsop L. Michels 《Brain topography》2013,26(3):442-457
While several studies have investigated interactions between the electroencephalography (EEG) and functional magnetic resonance imaging BOLD signal fluctuations, less is known about the associations between EEG oscillations and baseline brain haemodynamics, and few studies have examined the link between EEG power outside the alpha band and baseline perfusion. Here we compare whole-brain arterial spin labelling perfusion MRI and EEG in a group of healthy adults (n = 16, ten females, median age: 27 years, range 21–48) during an eyes closed rest condition. Correlations emerged between perfusion and global average EEG power in low (delta: 2–4 Hz and theta: 4–7 Hz), middle (alpha: 8–13 Hz), and high (beta: 13–30 Hz and gamma: 30–45 Hz) frequency bands in both cortical and sub-cortical regions. The correlations were predominately positive in middle and high-frequency bands, and negative in delta. In addition, central alpha frequency positively correlated with perfusion in a network of brain regions associated with the modulation of attention and preparedness for external input, and central theta frequency correlated negatively with a widespread network of cortical regions. These results indicate that the coupling between average EEG power/frequency and local cerebral blood flow varies in a frequency specific manner. Our results are consistent with longstanding concepts that decreasing EEG frequencies which in general map onto decreasing levels of activation. 相似文献
2.
da Cunha Jaeger Mariane Ghisleni Eduarda Chiesa Cardoso Paula Schoproni Siniglaglia Marialva Falcon Tiago Brunetto André T. Brunetto Algemir L. de Farias Caroline Brunetto Taylor Michael D. Nör Carolina Ramaswamy Vijay Roesler Rafael 《Journal of molecular neuroscience : MN》2020,70(6):981-992
Journal of Molecular Neuroscience - Medulloblastoma (MB), which originates from embryonic neural stem cells (NSCs) or neural precursors in the developing cerebellum, is the most common malignant... 相似文献
3.
Ghisleni G Porciúncula LO Cimarosti H Batista T Rocha J Salbego CG Souza DO 《Brain research》2003,986(1-2):196-199
Diphenyl diselenide (PhSe)2 is an organic selenium compound that has been little studied. In this study we investigated the effects of (PhSe)2 (0.1-3 microM) in a classical model of in vitro brain ischemia, which consists of exposing rat hippocampal slices to oxygen-glucose deprivation (OGD). Hippocampal slices were exposed for 60 min to OGD and the cellular viability (performed by MTT assay) as well as the immunocontent of nitric oxide synthase inducible (iNOS) were evaluated after 180 min of a recovery period. OGD decreased cellular viability by 50% and increased more than twice the immunocontent of iNOS of hippocampal slices. (PhSe)2 (1 and 3 microM) added during OGD and the recovery period abolished both effects. These results demonstrate for the first time the neuroprotective effects of (PhSe)2. Although the selenium analog--ebselen--has been widely used in ischemia models, our results suggest that other selenoorganic compounds could be investigated as pharmacological tools against brain disorders. 相似文献
4.
Ghisleni G Spagnolo V Roccabianca P Scanziani E Paltrinieri S Lupo F Ferretti E Nageli F 《Veterinary and human toxicology》2004,46(2):57-61
Biological markers of lead exposure were measured in 20 dogs from five different habitats chosen on the basis of the degree of anthropogenic influence. None of the dogs had clinical signs of lead poisoning. Compared to controls, blood lead concentrations were significantly higher in dogs from industrial areas, confirming the role of lead emissions in environmental pollution and the possible role of dogs as biomonitors of lead exposure in these areas. Whole blood lead concentrations were similar in dogs living in urban and rural areas, probably due to "indirect" lead sources and due to decreased urban lead contamination. As in humans, individual variability was detected. No significant correlation between clinico-pathological changes (hematology, clinical chemistry, Delta-aminolevulinic acid dehydratase activity and other intra-erythrocytic metabolic parameters) and lead concentration were observed. Our findings suggest dogs can be useful as sentinels of environmental lead exposure. 相似文献
5.
p73 Overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumor angiogenesis. 总被引:7,自引:0,他引:7
F Vikhanskaya M R Bani P Borsotti C Ghilardi R Ceruti G Ghisleni M Marabese R Giavazzi M Broggini G Taraboletti 《Oncogene》2001,20(50):7293-7300
Tumor neovascularization is controlled by a balance between positive and negative effectors, whose production can be regulated by oncogenes and tumor suppressor genes. The aim of this study was to investigate whether the angiogenic potential of tumors could also be controlled by p73, a gene homologous to the tumor suppressor p53, whose involvement in tumor angiogenesis is known. We have studied the production of proangiogenic (VEGF, FGF-2, PIGF and PDGF) and antiangiogenic (TSP-1) factors in two p73 overexpressing clones obtained from the human ovarian carcinoma cells A2780. TSP-1 was downregulated in both clones compared to mock transfected cells, both at mRNA and protein level. Conversely, both clones showed an increased production of VEGF mRNA and protein. For both TSP-1 and VEGF, regulation of expression was partially due to modulation of the promoter activity, and was dependent on p53 status. Production of the other angiogenic factors FGF-2, PIGF and PDGF-B was also increased in p73 overexpressing clones. The two clones were more angiogenic than parental cells, as shown in vitro by their increased chemotactic activity for endothelial cells, and in vivo by the generation of more vascularized tumors. These findings suggest a potential role of p73 in tumor angiogenesis. 相似文献
6.
Ghisleni G Kazlauckas V Both FL Pagnussat N Mioranzza S Rocha JB Souza DO Porciúncula LO 《Progress in neuro-psychopharmacology & biological psychiatry》2008,32(6):1508-1515
Diphenyl diselenide [(PhSe)2] is an organoselenium compound which presents pharmacological antioxidant, anti-inflammatory, antinociceptive and antidepressant properties. The present study was designed to investigate the anxiolytic effect of (PhSe)2 in rats, employing the elevated plus maze task. The involvement of 5HT and GABA receptors in the anxiolytic-like effect was also evaluated. (PhSe)2 (5, 25 and 50 micromol/kg, i.p.) did not affect locomotor activity as evaluated in the open open-field test, and learning and memory when assessed in the inhibitory foot-shock avoidance task. However, (PhSe)2 at the 50 micromol/kg dose produced signs of an anxiolytic action, namely a decreased number of fecal boli in the open-field arena and an increased time spent in as well as an increased number of entries to the open arms of the elevated plus maze test. To evaluate the role of GABA and 5HT receptors in the anxiolytic-like effect of (PhSe)2, a selective GABAA receptor antagonist bicuculline, (0.75 mg/kg, i.p.), a non-selective 5HT2A/2C receptor antagonist, ritanserin (2 mg/kg, i.p.), a selective 5HT2A receptor antagonist, ketanserin (1 mg/kg, i.p.), and a selective 5HT1A receptor antagonist, WAY100635 (0.1 mg/kg, i.p.) were used. All the antagonists used were able to abolish the anxiolytic effect of (PhSe)2 suggesting that GABAA and 5HT receptors may play a role in the pharmacological property of this selenocompound in the central nervous system. 相似文献
7.
Rosa Thiago Goulart dos Santos Sofia Nascimento de Jesus Andreoli Pinto Terezina Ghisleni Daniele Dal Molim Barja-Fidalgo Thereza Christina Ricci-Junior Eduardo Al-Qahtani Mohammed Kozempel Jan Bernardes Emerson Soares Santos-Oliveira Ralph 《Pharmaceutical research》2017,34(12):2922-2930
Pharmaceutical Research - The purpose of this article was to develop, characterize and test (in vivo) dacarbazine microparticles that may be labeled with 99mTc and Ra-223 for both use: diagnostic... 相似文献
8.
Bastos Clarissa Ribeiro Bock Bertha Bueno Xavier Janaina Camerini Laísa Dewes Samantha Seibt Grellert Mateus de Carvalho Hudson Wander Jansen Karen da Silva Ricardo Azevedo Pinheiro Ricardo Tavares de Mattos Souza Luciano Oses Jean Pierre Portela Luis Valmor Lara Diogo Rizzato Tovo-Rodrigues Luciana Ghisleni Gabriele 《European archives of psychiatry and clinical neuroscience》2023,273(1):41-50
European Archives of Psychiatry and Clinical Neuroscience - The influence of temperament traits on bipolar disorder (BD) has been investigated. Both temperament traits and BD are partially... 相似文献
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Colombo C Costantini D Zazzeron L Faelli N Russo MC Ghisleni D Gatelli I Giovannini M Riva E Zetterström R Agostoni C 《Acta paediatrica (Oslo, Norway : 1992)》2007,96(8):1228-1232
AIM: To study the effect of breastfeeding (BF) on growth, lung function and number of infections during the first 3 years of life in children with cystic fibrosis (CF). MATERIAL AND METHODS: One hundred forty-six CF patients, 5-18 years old, were recruited at their annual care visit. Information about infant feeding, psychosocial and socioeconomic conditions and smoking exposure was obtained by interviews. Anthropometric parameters at 1 year of age and the number of infections and hospitalisations during the first 3 years of life were obtained from clinical charts. Anthropometrics and pulmonary function parameters were obtained at enrollment. RESULTS: In CF patients, particularly those with pancreatic insufficiency, the prevalence of BF was lower than the general Italian population. After multivariate analysis patients with prolonged BF showed higher values of CED expiratory volume in 1 sec (FEV-1) (p = 0.001) and a lower number of infections during the first 3 years of life (p = 0.098). CONCLUSION: Prolonged BF is beneficial in children with CF and may protect them against decline of pulmonary function. Particular attention should be paid to promote BF in infants with CF. 相似文献