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1.
Anne Tournadre Bruno Pereira Laure Gossec Martin Soubrier Maxime Dougados 《Joint, bone, spine : revue du rhumatisme》2019,86(1):55-60
Objectives
To analyze the factors associated with fatigue focusing on comorbidities in a large cohort of rheumatoid arthritis (RA).Methods
Cross-sectional analyses were performed on RA patients from the French COMEDRA cohort study, a nurse-led program for comorbidities management. Fatigue was assessed using Question 3 of the Rheumatoid Arthritis Impact of Disease (RAID) score on a 0–10 numerical rating scale (NRS). Fatigue was defined as acceptable if?≤?2, moderate if 3 or 4, or severe if?≥?5 out of 10. Using univariate and multivariate models, the relationship between fatigue and demographics, social, disease characteristics, comorbidities (cardiovascular, infections, cancer, pulmonary, osteoporosis, and psychiatric disorders), physical activity, quality of life, and treatments was investigated.Results
In total, 962 patients were analyzed. The mean fatigue score was 3.8?±?2.7, 40% of patients reported severe fatigue. Patients had an average of 1.8 additional morbid conditions, with anxiety/depression the most common (52%). In univariate analysis, severe fatigue was more frequent in women, in patients not working, and in those with less physical activity. It was associated with disease duration and activity, mHAQ, pain, sleeping and emotional difficulties. Severe fatigue correlated with Multimorbidity index assessing the number of morbid conditions and was associated with obesity, hypertension, COPD, and anxiety/depression. In multivariate models, the risk of severe fatigue was associated with female gender, disease activity, mHAQ, current treatment with NSAIDs and biologics, multimorbidity, obesity and anxiety/depression.Conclusions
Assessment of comorbidities, psychological health and physical activity should be taken into account in order to address frequent RA-related severe fatigue. 相似文献2.
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4.
Bruno Costa MARTINS Clarissa Santos SOUZA Jennifer Nakamura RUAS Carlos Kiyoshi FURUYA Sonia Nadia FYLYK Christiano Makoto SAKAI Edson IDE 《Brazilian archives of digestive surgery》2020,33(3)
Open in a separate windowEndoscopic aspect of fundoplication anatomy: Normal aspect of Nissen fundoplication 相似文献
5.
Alessandro Rambaldi Alessandra Iurlo Alessandro M. Vannucchi Bruno Martino Attilio Guarini Marco Ruggeri Nikolas von Bubnoff Marianna De Muro Mary Frances McMullin Stefania Luciani Vincenzo Martinelli Axel Nogai Vittorio Rosti Alessandra Ricco Paolo Bettica Sara Manzoni Silvia Di Tollo 《Blood cancer journal》2021,11(3)
6.
Cristiana Cortes de Oliveira Carolina Ferreira Nicoletti Marcela Augusta de Souza Pinhel Bruno Affonso Parenti de Oliveira Driele Cristina Gomes Quinhoneiro Natália Yumi Noronha Priscila Giacomo Fassini Júlio Sérgio Marchini Wilson Araújo da Silva Júnior Wilson Salgado Júnior Carla Barbosa Nonino 《Clinical nutrition (Edinburgh, Scotland)》2018,37(4):1383-1388
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Angela Rouyar Marion Classe Raphael Gorski Marie‐Dominique Bock Joelle Le‐Guern Sandrine Roche Valerie Fourgous Anne Remaury Pascal Paul Clara Ponsolles Dominique Franon Laurence Rocheteau‐Beaujouan Margerie Clment El‐Bdaoui Haddad Jean‐Claude Guillemot Michel Didier Bruno Biton Cecile Orsini Vincent Mikol Maud Leonetti 《Allergy》2019,74(3):549-559
10.
Marco Aurélio Mori Ana Marcia Delattre Bruno Carabelli Claudia Pudell Mariza Bortolanza Pedro Vinícius Staziaki 《Nutritional neuroscience》2018,21(5):341-351
Objective: Parkinson's disease (PD) is characterized by deterioration of the nigrostriatal system and associated with chronic neuroinflammation. Glial activation has been associated with regulating the survival of dopaminergic neurons and is thought to contribute to PD through the release of proinflammatory and neurotoxic factors, such as reactive nitric oxide (NO) that triggers or exacerbates neurodegeneration in PD. Polyunsaturated fatty acids (PUFAs) exert protective effects, including antiinflammatory, antiapoptotic, and antioxidant activity, and may be promising for delaying or preventing PD by attenuating neuroinflammation and preserving dopaminergic neurons. The present study investigated the effects of fish oil supplementation that was rich in PUFAs on dopaminergic neuron loss, the density of inducible nitric oxide synthase (iNOS)-immunoreactive cells, and microglia and astrocyte reactivity in the substantia nigra pars compacta (SNpc) and striatal dopaminergic fibers.
Methods: The animals were supplemented with fish oil for 50 days and subjected to unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-induced lesions as a model of PD.
Results: Fish oil mitigated the loss of SNpc neurons and nerve terminals in the striatum that was caused by 6-OHDA. This protective effect was associated with reductions of the density of iNOS-immunoreactive cells and microglia and astrocyte reactivity.
Discussion: These results suggest that the antioxidant and antiinflammatory properties of fish oil supplementation are closely related to a decrease in dopaminergic damage that is caused by the 6-OHDA model of PD. 相似文献