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1.
Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment. 相似文献
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治疗1例多次发生血管内血栓形成伴肺栓塞患者,报告如下。1临床资料患者男,77岁,2001年11月—2005年11月4次发生双下肢血栓,两次导致肺栓塞,经多次溶栓、抗凝治疗,并行下腔静脉过滤网植入术。第1次静脉血栓形成于2001年11月6日,患者坐车5h后突发左下肢肿胀疼痛,伴胸痛发作。 相似文献
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1996年 4月至 1999年 8月 ,作者用三氧化二砷治疗骨髓增生异常综合征 (MDS) 2 2例 ,取得了一定疗效 ,并且发现骨髓中早幼粒细胞比值较高的患者疗效较好 ,现报道如下。1 临床资料1 1 一般资料 2 2例均为本院住院或门诊患者 ,符合MDS的诊断标准[1] ,男 9例 ,女 13例 ,年龄 19~ 6 4岁。难治性贫血伴有原始细胞增多 (RAEB) 9例 ,转变中的RAEB(RAEB T)11例 ,慢性粒单细胞白血病 (CMML) 2例。其中 18例曾接受1~ 3疗程化疗 ,12例服用过维甲酸 ,6例服用过维生素D3,4例用过干扰素 ,2例为初治患者。化疗者治疗时间为 2… 相似文献
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目的:探讨集体心理治疗对精神分裂症患疗效的影响。方法:将120例精神分裂症患随机分为药物治疗组和集体心理治疗(联合组)60例,药物治疗(药物组)60例,观察12周应用PANSS量表进行评定。结果:PANSS量表评分在8周后联合组显低于药物组(P<0.05),12周更加明显(P<0.01),治疗第12周末联合组的服药依从性显高于药物组(P<0.005)。结论:集体心理治疗能有效改善精神分裂症的精神症状,提高其服药依从性,促进其社会功能的恢复。 相似文献
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目的 为探索海宁市合理制订恶性肿瘤二级预防措施 ,改进诊疗方法 ,优化卫生资源配置 ,进行相关性调查研究。方法 随机抽样调查海宁市 1999年度诊断的 2 5 8例恶性肿瘤病例进行流行病学分析。结果 病理诊断为恶性肿瘤者 40 .0 % ;晚期病例占 85 .3% ,手术治疗占 36 .4% ,已死亡病例中位生存时间为 4个月 ,平均每例医疗开支 170 6 1元 ,专科医院与非专科医院比较 :住院时间 t=2 .32 ,P<0 .0 5 ,病死率 χ2 =4.80 ,P<0 .0 5。城镇病例与农村相比 :医疗费用高出近 1倍 ,平均生存时间反而农村比城镇长 ,t=15 .87,P<0 .0 1,差异有高度显著性。结论 医疗费用支出与生存时间不成正比 ;专科医院与非专科医院病死率存在显著差异。 相似文献
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Objective To evaluate the effect of haploidentical lymphocyte infusion on refractory and relapse acute leukemia. Methods The haploidentical donor lymphocyte infusion was used to treat for relapse acute myeloid leukemia 3 patients (M2 2 eases, M4 lcase), one relapse acute lymphocyte leukemia from April 2006 to October 2007. Four cases who had accepted secondly regimens were ineffective,after relapse. Collecting donor lymphocytes, parents children as donor supply in 3 cases, mother as donor supply one case. Before donor lymphocyte infusion patients received chemotherapy of different regimens. Donor haploidentical iymphocytes irradiated by 6-8 Gy radial were infused when patients white cell count was at the lowest after the chemotherapy. The average of infusion cells was 2.3 (1.4-3.1)×108/kg. Results One patient acquired complete remission and two patients were effective in three relapse acute myeloid leukemia. It was ineffective in relapse acute lymphocyte leukemia. No transfusion related graft versus host disease was observed. One patient has had herpes zoster virus infection. Conclusion Haploidentical donor lymphocyte infusion with chemotherapy are effective for refractory and relapse in acute myeloid leukemia, but the infused cell quantity and irradiated dosage must be further discussed. 相似文献