全文获取类型
收费全文 | 1065篇 |
免费 | 69篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 78篇 |
妇产科学 | 14篇 |
基础医学 | 135篇 |
口腔科学 | 71篇 |
临床医学 | 99篇 |
内科学 | 273篇 |
皮肤病学 | 25篇 |
神经病学 | 52篇 |
特种医学 | 52篇 |
外科学 | 93篇 |
综合类 | 20篇 |
一般理论 | 2篇 |
预防医学 | 77篇 |
眼科学 | 9篇 |
药学 | 58篇 |
肿瘤学 | 84篇 |
出版年
2021年 | 10篇 |
2020年 | 16篇 |
2019年 | 17篇 |
2018年 | 9篇 |
2017年 | 13篇 |
2016年 | 12篇 |
2015年 | 14篇 |
2014年 | 27篇 |
2013年 | 40篇 |
2012年 | 51篇 |
2011年 | 49篇 |
2010年 | 33篇 |
2009年 | 44篇 |
2008年 | 59篇 |
2007年 | 55篇 |
2006年 | 50篇 |
2005年 | 57篇 |
2004年 | 45篇 |
2003年 | 42篇 |
2002年 | 31篇 |
2001年 | 38篇 |
2000年 | 42篇 |
1999年 | 32篇 |
1998年 | 33篇 |
1997年 | 29篇 |
1996年 | 33篇 |
1995年 | 32篇 |
1994年 | 20篇 |
1993年 | 30篇 |
1992年 | 15篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 18篇 |
1988年 | 15篇 |
1987年 | 14篇 |
1986年 | 7篇 |
1985年 | 10篇 |
1984年 | 5篇 |
1983年 | 12篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 5篇 |
1978年 | 9篇 |
1977年 | 5篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 7篇 |
1967年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有1152条查询结果,搜索用时 44 毫秒
1.
Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options.
Iwona Pilecka Andrew Whatmore Rob Hooft van Huijsduijnen Benoit Destenaves Peter Clayton 《Trends in Endocrinology and Metabolism》2007,18(1):12-18
Our molecular understanding of growth hormone-induced signal transduction has improved significantly over the past decades. At the same time, human population genetics and the analysis of genetically engineered animals have led to the discovery of genes that control specific aspects of the overall growth process. Although, currently, growth disorders are still diagnosed and treated on empirical bases, it might soon be possible to stratify patients predominantly by genetic defect, with treatment based on our molecular understanding of the role of the affected gene in the disease. 相似文献
2.
神经生长因子对小鼠突触体内Ca^2+水平的调节作用 总被引:4,自引:1,他引:3
观察了多次海马内微注射NGF对小鼠突触体内游离钙水平的影响,并在离体情况下观察NGF对EGTA和CaCl2分别造成突触体内低钙和高钙状态的调节作用。结果如下:(1)在体实验表明,一定剂量的NGF可显著降低老年小鼠海马突触体内游离钙水平(P<005);(2)离体实验表明,当突触体游离钙水平降低时,适当剂量的NGF具有升高游离钙水平的作用;而突触体内游离钙水平升高时,则NGF有降低游离钙水平的作用。提示NGF对游离钙水平的双向调节作用可能是NGF改善老年性记忆衰退的作用机制。 相似文献
3.
Fungal infections in cancer patients: An international autopsy survey 总被引:33,自引:0,他引:33
G. Bodey B. Bueltmann W. Duguid D. Gibbs H. Hanak M. Hotchi G. Mall P. Martino F. Meunier S. Milliken S. Naoe M. Okudaira D. Scevola J. van't Wout 《European journal of clinical microbiology & infectious diseases》1992,11(2):99-109
In an attempt to estimate the frequency of fungal infections among cancer patients, a survey of autopsy examinations was conducted in multiple institutions in Europe, Japan and Canada. Fungal infections were identified most often in leukemic patients and transplant recipients (25 % each). Fifty-eight percent of fungal infections were caused byCandida spp. and 30 % byAspergillus spp. There was considerable variability in the frequency of fungal infections in different countries. Nevertheless, this study clearly demonstrates that fungal infections represent a common complication in cancer patients, especially in patients with leukemia. 相似文献
4.
5.
Two types of intraoral distribution of fluorotic enamel 总被引:1,自引:0,他引:1
W. H. van Palenstein Helderman L. Mabelya M. A. van't Hot K. G. König 《Community dentistry and oral epidemiology》1997,25(3):251-255
Abstract Different distributions of fluorotic dental enamel within the dentition have been described in the literature. This report describes two patterns of intraoral distribution. In nine Tanzanian low fluorosis communities with a prevalence of pitting fluorosis of less than 2% and in live moderate fluorosis communities with a prevalence of pitting fluorosis of 16–59%, incisors and first molars were the least affected teeth. In four high fluorosis communities with a prevalence of pitting fluorosis of 86–97%, maxillary incisors exhibited lower Thylstrup-Fejerskov Index values than the maxillary canines, premolars and molars. The mandibular teeth exhibited increasing Thylstrup-Fejerskov Index values from the anterior to the posterior region. The curves presenting the intraoral distribution of the severity of dental fluorosis corresponded with the curve presenting the completion time of primary enamel formation of the various tooth types, with the exception of the first molars in high fluorosis communities. The similarity of the curves suggests that the later in life enamel is completed, the higher is the severity of dental fluorosis. This relation seems to be explained by the prevailing feeding and dietary habits, which result in minimal intake of fluoride in the first 18 months of life during breastfeeding, followed by increasing fluoride ingestion in the following years through consumption of tea, seafish and F-containing magadi salt. 相似文献
6.
MY Mancao LJ Sindel PH Richardson FM Silver 《Acta paediatrica (Oslo, Norway : 1992)》1996,85(1):118-120
Croup is an acute infectious illness usually occurring in children; it is characterized by brassy cough and stridor. The main pathogens include mainly parainfluenza and influenza viruses. Recently there have been reports of prolonged croup caused by the herpes simplex viruses. We report two cases of prolonged croup due to herpes simplex types 1 and 2. We also review and summarize the reported pediatric cases of herpetic croup. 相似文献
7.
Duncan WC; Illingworth PJ; Young FM; Fraser HM 《Human reproduction (Oxford, England)》1998,13(9):2532-2540
The molecular mechanisms involved in luteolysis are still unclear in the
primate. This study aimed to investigate the effect of induced luteolysis
on the ovarian luteinizing hormone (LH) receptor and the steroidogenic
enzyme, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the marmoset
monkey. Luteolysis was induced in the mid-luteal phase either directly by
systemic prostaglandin F2alpha (PGF2alpha), or indirectly by LH withdrawal
using systemic gonadotrophin releasing hormone antagonist (GnRHant)
treatment. The LH receptor was studied by isotopic mRNA in-situ
hybridization and in-situ ligand binding and 3beta-HSD expression was
studied using isotopic mRNA in-situ hybridization and immunohistochemistry.
Induced luteolysis was associated with a reduction in the expression of LH
receptor (P < 0.0001) and 3beta-HSD mRNA, closely followed by a
reduction in the LH receptor (P < 0.05) and 3beta-HSD protein
concentrations within 24 h. There were no differences in the findings
whether luteolysis was induced with PGF2alpha or GnRHant. This study shows
that disparate mechanisms to induce luteolysis in the primate result in an
identical rapid loss of the LH receptor and 3beta-HSD. In conclusion,
induced luteolysis leads to rapid loss of the steroidogenic pathway in
luteal cells.
相似文献
8.
9.
10.