Changes in central dopaminergic systems with the expression of Shh or GDNF in mice perinatally exposed to bisphenol-A.

In the previous study, we reported that exposure to bisphenol-A induced the potentiation of dopamine receptor functions in the mouse limbic area, resulting in supersensitivity to methamphetamine-induced pharmacological actions. The present study was undertaken to investigate whether prenatal exposure to bisphenol-A could produce morphological change in dopaminergic neuron and the pattern of expression of genes regulating the dopaminergic neuron development. Here we found that prenatal and neonatal exposures to bisphenol-A increased the tyrosine hydroxylase- and dopamine transporter-like immunoreactivities in the adult mouse limbic area. The present molecular biological study shows that chronic bisphenol-A treatment produced a significant decrease in the dopaminergic neuron development factors, sonic hedgehog and glial cell line-derived neurotrophic factor, which were also decreased by prenatal exposure to bisphenol-A. These results suggest that chronic exposure to bisphenol-A could disrupt the dopaminergic neurotransmission in the process of dopaminergic neuron development.     

Functional results of the surgery of esophageal opening hernia]

The article presents an original method of laparoscopic anti-reflux surgery, immediate and long-term results of the treatment of 132 patients with esophageal opening hernia. It also describes the analysis of the life quality of patients with the gastroesophageal reflux disease before and after the surgery.     

Study by nontraditional analytic methods of features of cortical potentials,taking high-frequency components into account,in dogs during instrumental learning

A new method has been developed for the coding of EEG tracings which is an alternative to the classical spectral correlation analysis. This method has made it possible to compensate to a considerable degree for limitations which are unavoidable with the Fourier transform, and to obtain additional information regarding the form of the tracing, which reflects the fluctuations of brain potentials. The new system that has been presented for coding the EEG is, in our view, the most adequate (of the methods known to us) for identifying the individual features of the EEG, in terms of evaluating both their regional differences and similarities. The data obtained convince us once again of the real existence of high-frequency low-power components of the EEG, and their enhancement during instrumental learning in dogs (motor alimentary conditioned reflexes). In addition, data have been obtained pointing to the intensification in some regions of a slow-wave constituent; this has not been observed previously in carrying out a Fourier transform. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow. Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 44, No. 2, pp. 244–253, March–April, 1994.     

Organ-sparing operations in pyloroduodenal stenosis caused by peptic ulcer

An experience with the treatment of 106 patients with pyloroduodenal stenosis of ulcerous etiology by vagotomy with draining operations has shown high efficiency of these measures resulting in lower rate of postoperative lethality. Selective proximal and stem vagotomy does not aggravate gastric atony in patients with stenosis. Electro-stimulation was found to be an effective method of treatment of this complication in the postoperative period of patients with gastric atony.     

Atherogenic properties of beta adrenergic blockaders evident on vascular wall cells

In cultured human cells, beta-adrenoblockers such as propranolol, alprenolol, metoprolol, atenolol, pindolol, and thymolol, as well as sera from patients with coronary heart disease were examined for atherogenic activity following a single administration of propranolol (80 mg) and pindolol (10 mg). Addition of the beta-adrenoblockers to the cell culture was demonstrated to enhance cellular total cholesterol levels and to stimulation their proliferation. Propranolol and pindolol given in a single dose was found to result in the appearance of atherogenic properties of the patients' sera.     

Suppressive effect of immature erythroid cells on the B-cell proliferation

Immature erythroid cells suppress the proliferative response of preactivated B lymphocytes to lipopolysaccharide. The same effect is observed when recombinant human interleukin-2 or culture medium conditioned by preactivated T or B cells is added to cultured cells. Suppressive nucleate erythroid cells are resistant to leucine methyl ester. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 1, pp. 66–70, January, 1997