全文获取类型
收费全文 | 5683篇 |
免费 | 320篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 94篇 |
儿科学 | 50篇 |
妇产科学 | 76篇 |
基础医学 | 788篇 |
口腔科学 | 269篇 |
临床医学 | 375篇 |
内科学 | 1753篇 |
皮肤病学 | 176篇 |
神经病学 | 272篇 |
特种医学 | 144篇 |
外科学 | 835篇 |
综合类 | 24篇 |
预防医学 | 162篇 |
眼科学 | 81篇 |
药学 | 307篇 |
中国医学 | 5篇 |
肿瘤学 | 628篇 |
出版年
2023年 | 52篇 |
2022年 | 95篇 |
2021年 | 158篇 |
2020年 | 74篇 |
2019年 | 90篇 |
2018年 | 121篇 |
2017年 | 97篇 |
2016年 | 112篇 |
2015年 | 119篇 |
2014年 | 131篇 |
2013年 | 199篇 |
2012年 | 374篇 |
2011年 | 370篇 |
2010年 | 206篇 |
2009年 | 181篇 |
2008年 | 310篇 |
2007年 | 319篇 |
2006年 | 315篇 |
2005年 | 347篇 |
2004年 | 332篇 |
2003年 | 278篇 |
2002年 | 308篇 |
2001年 | 117篇 |
2000年 | 106篇 |
1999年 | 114篇 |
1998年 | 74篇 |
1997年 | 69篇 |
1996年 | 47篇 |
1995年 | 43篇 |
1994年 | 25篇 |
1993年 | 27篇 |
1992年 | 68篇 |
1991年 | 62篇 |
1990年 | 51篇 |
1989年 | 67篇 |
1988年 | 67篇 |
1987年 | 51篇 |
1986年 | 65篇 |
1985年 | 53篇 |
1984年 | 50篇 |
1983年 | 41篇 |
1982年 | 17篇 |
1979年 | 26篇 |
1978年 | 15篇 |
1977年 | 15篇 |
1974年 | 15篇 |
1972年 | 20篇 |
1970年 | 18篇 |
1969年 | 20篇 |
1968年 | 17篇 |
排序方式: 共有6039条查询结果,搜索用时 468 毫秒
1.
2.
Kentaro Yamasaki Takafumi Ishida Tatsuya Kishino Norio Niikawa 《American journal of medical genetics. Part A》2002,111(3):301-306
We report on a Thai family with dominantly inherited malformation syndrome with upper limb anomalies, short stature, quadricuspid aortic valve, and minor craniofacial anomalies. The affected individuals comprised a mildly affected mother, a moderately affected daughter, and a most severely affected son. The daughter and son had short stature. The craniofacial abnormalities comprised frontal bossing, hypoplastic nasal bones, depressed nasal bridge, and broad nasal alae. The upper limb defects varies among the patients, ranging from radial ray defects in the mother through radial and ulnar ray defects with unilateral humeral hypoplasia in the daughter to radial ray defects with severe oligodactyly and bilateral humeral hypoplasia in the son. All patients in this family had hypoplasia of the shoulder girdle and resembled what is observed in many families with Holt‐Oram syndrome. Moreover, the son showed quadricuspid aortic valve with mild aortic regurgitation. However, the present family did not show any mutation of the TBX5 gene, a disease‐causing gene of Holt‐Oram syndrome. The present family deserves further investigation on other genes that play a role in the development of the upper limbs, particularly of radial rays. © 2002 Wiley‐Liss, Inc. 相似文献
3.
4.
5.
Shigeru Onodera Koji Saito Takafumi Saito Hitoshi Togashi Sumio Kawata Katsuaki Ukai Haruhide Shinzawa 《Nihon Shokakibyo Gakkai zasshi》2007,104(2):213-218
It is well known that long-term infection with Clonorchis sinensis often causes bile duct cancer, usually. It occurs in the intrahepatic bile duct. We encountered a rare case of clonorchiasis complicated with duodenal papillary cancer. The patient was a woman from China. Although clonorchiasis is rarely found in Japan, the promotion of international exchange may increase the number of visitors from endemic areas. Thus we must pay sufficient attention to this disease. Also, we reported that the microplate ELISA technique was useful in the diagnosis of clonorchiasis with high accuracy in this case. 相似文献
6.
Design of a Centrifugal Blood Pump with Magnetic Suspension 总被引:1,自引:0,他引:1
Takashi Yamane Tadashige Ikeda Toyoki Orita Tatsuo Tsutsui Tomoaki Jikuya 《Artificial organs》1995,19(7):625-630
Abstract: A new concept blood pump, whose impeller is suspended by permanent magnets and a mechanical pivot without seals or ball bearings, is presented in this paper. The primary aim of the blood pump is an application to implantable artificial hearts. The prototype model is of a centrifugal type with a four-vaned semiopen impeller 50 mm in diameter. Since this mechanism has no seals or ball bearings, flow stagnation or heat generation that might cause blood cell denaturation is expected to be small. The results of performance testing for the prototype model 2 were satisfactory regarding pump head and efficiency. The radial-suspension magnets and the magnetic coupling were stable. As a result, the present mechanism has been verified to be a candidate applicable to implantable artificial hearts. 相似文献
7.
S Sohen P L Romain D M Rothstein T Yamane S Tanaka P Anderson S F Schlossman C Morimoto 《The Journal of rheumatology》1991,18(11):1649-1654
We analyzed the cell surface phenotype of CD8+ cells in both peripheral blood and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Utilizing the monoclonal antibodies anti-CD45RA, anti-CD29 and anti-S6F1-, one can define both suppressor effector (CD45RA+CD29-S6F1-) and killer effector (CD45RA-CD29+S6F1+) cells within the CD8 population. In patients with OA, normal proportions of CD8+CD45RA+, CD8+CD29+ and CD8+S6F1+ cells were found in both peripheral blood and SF. The peripheral blood of patients with RA, in contrast, showed a decreased percentage of CD8+CD45RA+ cells (13.4 +/- 2.6) (p less than 0.05), but a normal percentage of CD8+CD29+ and CD8+S6F1+ cells. In the SF of patients with RA, we observed a more dramatic decrease in CD8+CD45RA+ suppressor effector cells (6.4 +/- 5.0) (p less than 0.001), a significant increase in killer effector cells as measured by both CD8 + CD29+ (35.5 +/- 9.9) (p less than 0.001) and CD8 + S6F1+ cells (28.2 +/- 11.4) (p less than 0.01). These changes may contribute to the immunologic abnormalities previously noted in this disease and may provide some insight into the pathophysiologic mechanisms of RA. 相似文献
8.
K Yamane G P Shome T Akama H Suzuki Y Matsui H Kashiwagi 《Scandinavian journal of rheumatology》1991,20(6):397-405
Clinical features of 16 patients with mild systemic lupus erythematosus (SLE) were compared with those of 21 control patients with moderate or severe disease. Age at the time of diagnosis of SLE was higher in mild disease group. The incidence of the coexistence of Sj?gren's syndrome (SS) at the time of diagnosis of SLE was higher in patients who later developed mild disease. Anti-Sm antibody and decreased levels of C3, C4, and CH50 occurred less frequently in patients with mild disease. SLE patients with the coexistence of SS at the time of diagnosis of SLE may represent a subset with a benign prognosis. 相似文献
9.
Yukata Okita M.D. Shigehito Miki M.D. Yuichi Ueda M.D. Takafumi Tahata M.D. Tetsuro Sakai M.D. Katsuhiko Matsuyama M.D. Masahiko Matsumura M.D. 《Journal of cardiac surgery》1994,9(4):433-439
A 6-year-old boy was successfully operated on for double outlet ventricle, common atrioventricular canal with severe valvular regurgitation, right atrial Isomerism, L-loop ventricles, total anomalous pulmonary venous connection, and pulmonary stenosis with hypoplastic left pulmonary artery. The Interventricular rerouting from the left ventricle to the ascending aorta was performed with a spiral patch, the lnteratrlal switching was performed by a Mustard patch, the common atrioventricular orifice was partitioned and valve repair was performed, and an 18-mm valved conduit was inserted between the right ventricle and the pulmonary artery. Although the patient had a small residual ventricular septal defect and pulmonary stenosls, the patient Is alive and well. 相似文献
10.
A focal cerebral ischemic model was produced by occlusion of the intracranial main cerebral artery with a silicone cylinder in normotensive (NTR) and spontaneously hypertensive rats (SHR). Main cerebral artery could be successfully occluded in approximately 90%. The most frequent embolized site was the distal part of the internal cerebral artery (ICb) and less frequently the horizontal segment of the anterior cerebral artery (Al). Mortality rate of NTR with ICb occlusion (NTR-ICb) was 43% at 72 hours after embolization and that of SHR with ICb occlusion (SHR-ICb) was 67% at 24 hours after embolization. NTR-ICb showed neurological signs (i.e. circling movement, hemiparesis, poor response to pain stimuli) and histologically, showed infarction in the deep cerebral structures (i.e. thalamus, hypothalamus, hippocampus, and internal capsule) accompanied with mild disruption of blood-brain barrier (BBB). SHR-ICb showed more serious neurological signs and more severe cerebral infarction in the deep cerebral structures with severe disruption of BBB. In SHR-ICb, ischemic cerebral edema was more prominent which may deteriorate symptoms and pathological findings compared to NTR-ICb. This embolization model is proposed to be useful for studying the pathophysiology of focal cerebral ischemia, especially, early ischemic edema. 相似文献