全文获取类型
收费全文 | 865篇 |
免费 | 55篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 14篇 |
妇产科学 | 22篇 |
基础医学 | 55篇 |
口腔科学 | 40篇 |
临床医学 | 57篇 |
内科学 | 327篇 |
皮肤病学 | 17篇 |
神经病学 | 47篇 |
特种医学 | 42篇 |
外科学 | 151篇 |
综合类 | 3篇 |
预防医学 | 26篇 |
眼科学 | 33篇 |
药学 | 36篇 |
肿瘤学 | 58篇 |
出版年
2024年 | 1篇 |
2023年 | 25篇 |
2022年 | 19篇 |
2021年 | 33篇 |
2020年 | 20篇 |
2019年 | 24篇 |
2018年 | 26篇 |
2017年 | 35篇 |
2016年 | 22篇 |
2015年 | 24篇 |
2014年 | 48篇 |
2013年 | 61篇 |
2012年 | 76篇 |
2011年 | 85篇 |
2010年 | 42篇 |
2009年 | 35篇 |
2008年 | 59篇 |
2007年 | 60篇 |
2006年 | 61篇 |
2005年 | 38篇 |
2004年 | 34篇 |
2003年 | 19篇 |
2002年 | 28篇 |
2001年 | 8篇 |
2000年 | 8篇 |
1999年 | 9篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 7篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1983年 | 1篇 |
1979年 | 2篇 |
排序方式: 共有930条查询结果,搜索用时 0 毫秒
1.
Serafim N. Nanas John N. Nanas Christos E. Charitos Alexandros Gougoulakis Konstantinos Makaritsis John Chatzigeorgiou Kiriaki Moussoutzani Maria I. Anastasiou-Nana Spyridon D. Moulopoulos 《World journal of surgery》1997,21(3):318-322
p
< 0.001), the tension time index (712 ± 381 versus 1333 ± 694,
p
< 0.01), and the double product (5629 ± 2574 versus 7440 ± 3294,
p
< 0.01) were significantly lower during assistance with the PACD than with the CBP. It was concluded that PACD is at least
as effective as CBP for restoring hemodynamic status during acute experimental cardiogenic shock. Moreover, the PACD unloads
the left ventricle more effectively than CBP, making it suitable for left ventricular mechanical support in cases with reversible
myocardial damage. 相似文献
2.
Spyridon Tsirigkakis George Mastorakos Yiannis Koutedakis Vassilis Mougios Alan M. Nevill Zoe Pafili Gregory C. Bogdanis 《Nutrients》2021,13(4)
The effects of two high-intensity interval training (HIIT) protocols on regional body composition and fat oxidation in men with obesity were compared using a parallel randomized design. Sixteen inactive males (age, 38.9 ± 7.3 years; body fat, 31.8 ± 3.9%; peak oxygen uptake, VO2peak, 30.9 ± 4.1 mL/kg/min; all mean ± SD) were randomly assigned to either HIIT10 (48 × 10 s bouts at 100% of peak power [Wpeak] with 15 s of recovery) or HIIT60 group (8 × 60 s bouts at 100% Wpeak with 90 s of recovery), and subsequently completed eight weeks of training, while maintaining the same diet. Analyses of variance (ANOVA) showed only a main effect of time (p < 0.01) and no group or interaction effects (p > 0.05) in the examined parameters. Total and trunk fat mass decreased by 1.81 kg (90%CI: −2.63 to −0.99 kg; p = 0.002) and 1.45 kg (90%CI: −1.95 to −0.94 kg; p < 0.001), respectively, while leg lean mass increased by 0.86 kg (90%CI: 0.63 to 1.08 kg; p < 0.001), following both HIIT protocols. HIIT increased peak fat oxidation (PFO) (from 0.20 ± 0.05 to 0.33 ± 0.08 g/min, p = 0.001), as well as fat oxidation over a wide range of submaximal exercise intensities, and shifted PFO to higher intensity (from 33.6 ± 4.6 to 37.6 ± 6.7% VO2peak, p = 0.039). HIIT, irrespective of protocol, improved VO2peak by 20.0 ± 7.2% (p < 0.001), while blood lactate at various submaximal intensities decreased by 20.6% (p = 0.001). In conclusion, both HIIT protocols were equally effective in improving regional body composition and fat oxidation during exercise in obese men. 相似文献
3.
Neurosurgical Review - Hydrocephalus in children with primary intradural spinal cord tumors is exceedingly rare. Herewith, we performed a systematic literature review to address epidemiology,... 相似文献
4.
Spyridon N. Karras Theocharis Koufakis Lilian Adamidou Vasiliki Antonopoulou Paraskevi Karalazou Katerina Thisiadou 《International journal of food sciences and nutrition》2021,72(1):82-92
AbstractFor seven weeks, 37 overweight adults followed a hypocaloric diet based on Orthodox Fasting (OF). A hypocaloric, time restricted eating (TRE) plan (eating between 08:00 to 16:00?h, water fasting from 16:00 to 08:00?h) was followed by 23 Body Mass Index (BMI)-matched participants. Anthropometric, glycaemic and inflammation markers and serum lipids were assessed before and after the diets. Both OF and TRE groups demonstrated reductions in BMI (28.54?±?5.45 vs 27.20?±?5.10?kg/m2, p?<?0.001 and 26.40?±?4.11 vs 25.81?±?3.78?kg/m2 p?=?0.001, respectively). Following the intervention, the OF group presented lower concentrations of total and low-density lipoprotein-cholesterol, compared with the pre-fasting values (178.40?±?34.14 vs 197.17?±?34.30?mg/dl, p?<?0.001 and 105.89?±?28.08 vs 122.37?±?29.70?mg/dl, p?<?0.001, respectively). Neither group manifested significant differences in glycaemic and inflammatory parameters. Our findings suggest that OF has superior lipid lowering effects than the TRE pattern. 相似文献
5.
Usefulness of thoracoscopic surgery in the diagnosis and management of thoracic diseases 总被引:5,自引:0,他引:5
Petrakis I Katsamouris A Drossitis I Bouros D Chalkiadakis G 《The Journal of cardiovascular surgery》2000,41(5):767-771
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) has been recently utilised in the diagnosis and management of thoracic diseases. In this article we report our series of patients with established indications for VATS treatment. METHODS: Over the past 6 years we performed 104 VATS procedures for diagnostic and therapeutic purposes in 95 men and 39 women. The specific indications for VATS were: lung biopsy for undiagnosed diffuse lung disease, mediastinal biopsy and cysts, pleural effusion, empyema, pneumothorax and bullous lung disease, pericardial effusion and cyst, parvertebral abscess and solitary pulmonary nodules. RESULTS: There was no operative mortality. Postoperative non-fatal complications were seen in 7 cases. The overall median duration of chest tube drainage was 2.5 days and the mean postoperative stay 3 days. In diffuse lung disease a tissue diagnosis was obtained in all cases. Definitive diagnosis in the patients with undiagnosed pleural effusion was obtained in 90% of cases and the overall diagnostic rate was 98.5%. The success rate of the empyema (stage II) treatment and the therapeutic procedures is 100% after a mean follow-up of 12 months (range 6-30). Conversion to thoracotomy was needed in 6 cases. In all patients the postoperative pain was controlled with intake of non-narcotic analgesics with satisfactory results. CONCLUSIONS: VATS is worth considering and has been established as procedure of choice, with exceptional results in various chest diseases such as undiagnosed pleural effusions, recurrent, post-traumatic or complicated spontaneous pneumothorax, stage II empyema, accurate staging for lung cancer in the resection of peripheral solitary pulmonary nodule less than 3 cm, and lung biopsy for pulmonary diffuse disease. 相似文献
6.
Stefan Pilz Verena Theiler-Schwetz Pawel Pludowski Sieglinde Zelzer Andreas Meinitzer Spyridon N. Karras Waldemar Misiorowski Armin Zittermann Winfried Mrz Christian Trummer 《Nutrients》2022,14(12)
Pathogenic mutations of CYP24A1 lead to an impaired catabolism of vitamin D metabolites and should be considered in the differential diagnosis of hypercalcemia with low parathyroid hormone concentrations. Diagnosis is based on a reduced 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D ratio and confirmed by genetic analyses. Pregnancy is associated with an upregulation of the active vitamin D hormone calcitriol and may thus particularly trigger hypercalcemia in affected patients. We present a case report and a narrative review of pregnant women with CYP24A1 mutations (13 women with 29 pregnancies) outlining the laboratory and clinical characteristics during pregnancy and postpartum and the applied treatment approaches. In general, pregnancy triggered hypercalcemia in the affected women and obstetric complications were frequently reported. Conclusions on drugs to treat hypercalcemia during pregnancy are extremely limited and do not show clear evidence of efficacy. Strictly avoiding vitamin D supplementation seems to be effective in preventing or reducing the degree of hypercalcemia. Our case of a 24-year-old woman who presented with hypercalcemia in the 24th gestational week delivered a healthy baby and hypercalcemia resolved while breastfeeding. Pathogenic mutations of CYP24A1 mutations are rare but should be considered in the context of vitamin D supplementation during pregnancy. 相似文献
7.
Andriana I. Papaioannou Evangelia Fouka Despina Papakosta Spyridon Papiris Stelios Loukides 《Clinical and experimental allergy》2021,51(2):221-227
During the last decades, new treatments targeting disease mechanisms referred as biologics have been introduced in the therapy of asthma and currently, five monoclonal antibodies have been approved. Although these therapeutic agents have been formulated to target specific asthma endotypes, it is often difficult for the treating physician to identify which patient is the best candidate for each one of these specific treatments especially in the clinical scenario of a patient in whom clinical characteristics overlap between different endotypes, allowing the selection of more than one biologic agent. As no head-to-head comparisons between these biologics have been attempted, there is no evidence on the superiority of one biologic agent over the other. Furthermore, a physician's first therapeutic decision, no matter how carefully has been made, may often result in suboptimal clinical response and drug discontinuation, indicating the need for switching to a different biologic. In this short review, we discuss the available evidence regarding the switching between biologics in patients with severe asthma and we propose a simple algorithm on switching possibilities in case that the physicians’ initial choice is proven not to be the best. 相似文献
8.
9.
Jiolanda Zika Sotirios Giannopoulos Ioannis Kastanioudakis Athanasios P. Kyritsis Spyridon Voulgaris 《The journal of spinal cord medicine》2020,43(2):206-210
Context/Objective: To investigate prospectively preoperative parameters that might be related to the outcome of surgically treated patients for cervical spondylotic myelopathy (CSM).Design: Prospective study.Setting: Single Center in Ioannina, Greece.Participants: Thirty-six patients were included in the study. There were 21 males and 15 females, mean age 50.8 years, range 39–70 years. The mean BMI was 27.3.Outcome measures: From each patient, we recorded age, sex, BMI, symptoms, duration of symptoms, comorbidities, lifestyle, myelopathy grade based on MRI and levels of compression. All patients completed the modified JOA (mJOA) and NPE questionnaires preoperatively and at 1, 3, 12 months and 5-years postoperatively.Results: The mean mJOA score significant improved from 10.8?±?1.9 points preoperatively to 16.6?±?2.2 points at 12 months postoperatively. The mean mJOA score at 5-years postoperatively was 15.5?±?3 points. The difference was still highly significant. The mean NPE score significant improved from 59.8?±?12.2 points preoperatively to 28.2?±?8.5 points at 1 month, to 35.8?±?8.1 points at 3 month and to 28.2?±?8.8 points at 12 months postoperatively. Younger patients had significant higher baseline mJOA scores and significant higher mJOA scores 5-year postoperatively. No correlation was found between sex, BMI, symptom duration, baseline mJOA or myelopathy grade and outcome at 12 months or 5-year postoperatively.Conclusion: Age was highly predictive factor of outcome for patients undergoing surgical treatment of CSM. 相似文献
10.