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The relationship between cyclic AMP production and the response of isolated canine parietal cells to histamine has been examined. Histamine increased cyclic AMP generation, and this effect correlated with histamine stimulation of oxygen consumption and aminopyrine accumulation. Metiamide inhibited histamine-stimulated cyclic AMP generation and oxygen consumption in a parallel fashion. At concentrations below 100 microM, isobutyl AMP production and oxygen consumption in a similar fashion. However, with IMX above 100 microM, histamine caused no further increases in oxygen consumption, despite markedly enhanced cyclic AMP generation. Neither carbachol nor gastrin increased cyclic AMP production beyond that produced by IMX alone, and the combinations of histamine and carbachol and of histamine and gastrin produced no greater cyclic AMP generation than produced by histamine. These findings support a close relationship between cyclic AMP production and the action of histamine but not of carbachol or gastrin on isolated parietal cells. The mechanisms underlying the potentiating interactions between histamine, carbachol, and gastrin involve step(s) beyond stimulation of cyclic AMP generation. 相似文献
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James E. Mitchell Harold C. Seim Debbie Glotter Elizabeth A. Soll Richard L. Pyle 《The International journal of eating disorders》1991,10(2):209-214
Bulimia nervosa is a common medical problem among young women of childbearing potential. Although many bulimic women improve their eating while pregnant, some do not and continue to binge eat, vomit, and/or use laxatives. This study is a retrospective comparison of the outcome of 38 pregnancies in 20 actively bulimic women and 50 pregnancies in 31 control women. The results indicate that the risk of fetal loss, primarily through miscarriages, was approximately twice as high in first bulimic pregnancies. However, this difference was not statistically significant. 相似文献
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Cristine S. Velazco Brenna S. Fullerton Charles R. Hong Kate A. Morrow Erika M. Edwards Roger F. Soll Tom Jaksic Jeffrey D. Horbar Biren P. Modi 《Journal of pediatric surgery》2018,53(1):108-112
Background
Necrotizing enterocolitis (NEC) is classically a disease of prematurity, with less reported regarding morbidity and mortality of this disease among other infants.Methods
Data were prospectively collected from 2009 to 2015 at 252 Vermont Oxford Network member centers on neonates with birth weight > 2500 g admitted to a participating NICU within 28 days of birth.Results
Of 1629 neonates with NEC, gestational age was 37 (36, 39) weeks, and 45% had major congenital anomalies, most commonly gastrointestinal defects (20%), congenital heart defects (18%), and chromosomal anomalies (7%). For the 23% of infants who had surgery for NEC, mortality and length of stay were 23% and 63 (36, 94) days versus 8% and 34 (22, 61) days in medical NEC. Independent predictors of mortality were congenital heart defects (p < 0.0001), chromosomal abnormalities (p < 0.05), other congenital malformations (p < 0.001), surgical NEC (p < 0.0001), and sepsis (p < 0.05). All of these in addition to gastrointestinal defects were independent predictors of increased length of stay. Nutritional morbidity at discharge included 6% receiving no enteral feeds and 27% who were < 10th percentile weight-for-age.Conclusions
Major congenital anomalies are present in nearly half of > 2500 g birth weight infants diagnosed with necrotizing enterocolitis. Morbidity and mortality increase with sepsis, surgical disease, and congenital anomalies.Type of study
Prognosis Study.Level of evidence
Level II. 相似文献10.
Genetic similarity of Candida albicans strains from vaginitis patients and their partners. 总被引:3,自引:11,他引:3 下载免费PDF全文
The moderately repetitive sequence Ca3 was used to fingerprint strains of Candida albicans isolated from vulvovaginal infections of 10 women and strains isolated from their male partners. The Dendron software package was then used to compare the DNA fingerprints of these strains with those of vaginal commensals from women from the same geographical locale, vaginal commensals from women from a different geographical locale, and commensals from male partners of asymptomatic women from the same geographical locale. The results demonstrate that, in the majority of cases (8 of 10), strains from symptomatic patients and their partners are either identical or more similar to each other than to other strains, infecting strains do not represent a group genetically distinguishable from vaginal commensal isolates from women from the same geographical locale, and both infecting strains and commensals from individuals in the test locale can be distinguished from commensals obtained in another geographical locale. The results also suggest that women with vaginal infections are responsible for strain replacement in their male partners. 相似文献