全文获取类型
收费全文 | 1012篇 |
免费 | 51篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 46篇 |
妇产科学 | 33篇 |
基础医学 | 89篇 |
口腔科学 | 30篇 |
临床医学 | 124篇 |
内科学 | 241篇 |
皮肤病学 | 43篇 |
神经病学 | 69篇 |
特种医学 | 110篇 |
外科学 | 69篇 |
综合类 | 72篇 |
预防医学 | 46篇 |
眼科学 | 38篇 |
药学 | 35篇 |
中国医学 | 1篇 |
肿瘤学 | 33篇 |
出版年
2022年 | 6篇 |
2021年 | 13篇 |
2020年 | 7篇 |
2018年 | 13篇 |
2017年 | 7篇 |
2016年 | 20篇 |
2015年 | 21篇 |
2014年 | 23篇 |
2013年 | 76篇 |
2012年 | 25篇 |
2011年 | 32篇 |
2010年 | 44篇 |
2009年 | 36篇 |
2008年 | 26篇 |
2007年 | 47篇 |
2006年 | 22篇 |
2005年 | 21篇 |
2004年 | 28篇 |
2003年 | 21篇 |
2002年 | 15篇 |
2001年 | 14篇 |
2000年 | 11篇 |
1999年 | 15篇 |
1998年 | 51篇 |
1997年 | 47篇 |
1996年 | 37篇 |
1995年 | 26篇 |
1994年 | 31篇 |
1993年 | 35篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 14篇 |
1989年 | 35篇 |
1988年 | 20篇 |
1987年 | 23篇 |
1986年 | 15篇 |
1985年 | 8篇 |
1984年 | 9篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 12篇 |
1980年 | 10篇 |
1977年 | 5篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1965年 | 5篇 |
1963年 | 6篇 |
1962年 | 5篇 |
1960年 | 5篇 |
1941年 | 11篇 |
排序方式: 共有1088条查询结果,搜索用时 0 毫秒
1.
HUGH F. MOLLOY F.A.C.D. ERIC LAMONT-GREGORY M.SC. CHRIS IDZIKOWSKI PH.D. F.B.PS.S. TERENCE J. RYAN D.M. F.R.C.P. 《International journal of dermatology》1993,32(9):668-672
Background. Extensive questioning of patients with a wide variety of skin disorders led to the impression that nocturnal overheating was probably an important factor in the initiation and the perpetuation of many skin disorders. Methods. In order to test the hypothesis, 12 “clean-skinned” subjects (6M/6F) aged 18 to 45 years were monitored electronically every 30 seconds during an 8 hour sleep period (2300 to 0700 hours), sleeping under a standard 10 tog duvet. Results. All the subjects were too hot by 3 to 4°C. All showed changes in their EEG patterns with reduced REM sleep, increased awakenings, and all showed changes in their sleep stage patterns. In addition, they all showed evidence of increased sweating in the “heat-sink” area. Conclusions. The mechanisms where by such changes could be implicated in the precipitation and perpetuation of skin disease are discussed. “Lifestyle” modification as a very effective, noninvasive, therapeutic regime is recommended. Further research along these lines would probably be very valuable and instructive. 相似文献
2.
3.
Sezen Ozoktay Robert Sarreck Leslie L. Alexander 《Journal of the National Medical Association》1981,73(2):161-163
Primary osteomyelitis of the pubic bone has not been recorded previously. The authors present a case of this unusual entity. 相似文献
4.
5.
Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for μ receptors, and the S antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of δ-, and possibly μ-, opioid receptors in the dorsal vagal complex. 相似文献
6.
Anderson RA; Evans LW; Irvine DS; McIntyre MA; Groome NP; Riley SC 《Human reproduction (Oxford, England)》1998,13(12):3319-3325
Follistatin is a binding protein for the activin and inhibin family of
hormones, regulating their biological activity. In the male reproductive
tract, the interaction of these factors is likely to be involved in the
regulation of the proliferation of several cell types. We have investigated
the presence of follistatin and activin A in seminal plasma using specific
immunoassays and have localized follistatin and activin/inhibin subunits in
the adult human testis, prostate and seminal vesicle to establish their
likely sources. High concentrations of immunoreactive follistatin were
present in seminal plasma in normal men (mean 97.9 ng/ml; 1.43 ng/ml in
peripheral plasma) and were similar in men with oligo/azoospermia and
following vasectomy. Follistatin immunoreactivity was localized to both
Leydig and Sertoli cells of the testis, and to epithelial cells of the
prostate gland and seminal vesicle, which are likely to be the predominant
sources of the hormone in seminal plasma. Activin A was also present in
seminal plasma in normal men but was undetectable following vasectomy, thus
deriving from the testis. Consistent with this finding, the betaA-subunit
was immunolocalized in Sertoli and Leydig cells but was not present in
seminal vesicle or prostate gland. The functional significance of the high
concentrations of follistatin secreted into seminal plasma by the prostate
gland and/or seminal vesicle is uncertain, but they may regulate the
biological activity of testis-derived activin A and inhibin B.
相似文献
7.
8.
9.
Y chromosome microdeletions, in azoospermic or near-azoospermic subjects, are located in the AZFc (DAZ) subregion 总被引:9,自引:2,他引:9
Submicroscopic deletions of the Y chromosome and polymorphisms of the
androgen receptor (AR) gene in the X chromosome have been observed in men
with defective spermatogenesis. To further define the subregions/genes in
the Y chromosome causing male infertility and its relationship to
polymorphisms of the AR polyglutamine tract, we screened the genomic DNA of
202 subfertile males and 101 healthy fertile controls of predominantly
Chinese ethnic origin. Y microdeletions were examined with 16
sequence-tagged site (STS) probes, including the RBM and DAZ genes,
spanning the AZFb and AZFc subregions of Yq11, and related to the size of
trinucleotide repeat encoding the AR polyglutamine tract. Y microdeletions
were detected and confirmed in three out of 44 (6.8%) of azoospermic and
three out of 86 (3.5%) severely oligozoospermic patients. No deletions were
detected in any of the patients with sperm counts of >0.5 x 10(6)/ml,
nor in any of the 101 fertile controls. All six affected patients had
almost contiguous Y microdeletions spanning the entire AZFc region
including the DAZ gene. The AZFb region, containing the RBM1 gene, was
intact in five of the six subjects. Y deletions were not found in those
with long AR polyglutamine tracts. Our study, the first in a Chinese
population, suggest a cause and effect relationship between Y
microdeletions in the AZFc region (possibly DAZ), and azoospermia or
near-azoospermia. Y microdeletions and long AR polyglutamine tracts appear
to be independent contributors to male infertility.
相似文献
10.