全文获取类型
收费全文 | 14029篇 |
免费 | 953篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 88篇 |
儿科学 | 553篇 |
妇产科学 | 381篇 |
基础医学 | 1691篇 |
口腔科学 | 184篇 |
临床医学 | 2355篇 |
内科学 | 2315篇 |
皮肤病学 | 187篇 |
神经病学 | 1236篇 |
特种医学 | 737篇 |
外科学 | 1282篇 |
综合类 | 249篇 |
一般理论 | 24篇 |
预防医学 | 1538篇 |
眼科学 | 296篇 |
药学 | 868篇 |
2篇 | |
中国医学 | 10篇 |
肿瘤学 | 1030篇 |
出版年
2023年 | 56篇 |
2022年 | 131篇 |
2021年 | 220篇 |
2020年 | 147篇 |
2019年 | 230篇 |
2018年 | 272篇 |
2017年 | 215篇 |
2016年 | 223篇 |
2015年 | 258篇 |
2014年 | 342篇 |
2013年 | 629篇 |
2012年 | 789篇 |
2011年 | 905篇 |
2010年 | 538篇 |
2009年 | 507篇 |
2008年 | 833篇 |
2007年 | 830篇 |
2006年 | 901篇 |
2005年 | 869篇 |
2004年 | 915篇 |
2003年 | 856篇 |
2002年 | 771篇 |
2001年 | 177篇 |
2000年 | 128篇 |
1999年 | 160篇 |
1998年 | 287篇 |
1997年 | 248篇 |
1996年 | 220篇 |
1995年 | 194篇 |
1994年 | 148篇 |
1993年 | 159篇 |
1992年 | 122篇 |
1991年 | 90篇 |
1990年 | 91篇 |
1989年 | 124篇 |
1988年 | 103篇 |
1987年 | 111篇 |
1986年 | 122篇 |
1985年 | 108篇 |
1984年 | 88篇 |
1983年 | 98篇 |
1982年 | 88篇 |
1981年 | 83篇 |
1980年 | 105篇 |
1979年 | 53篇 |
1978年 | 57篇 |
1977年 | 53篇 |
1976年 | 53篇 |
1975年 | 56篇 |
1973年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Thomas J Birk Rodger D MacArthur Lynn M Lipton Sheldon D Levine 《The Journal of the Association of Nurses in AIDS Care》2002,13(6):20-24
The purpose of this study was to determine whether blood lipid and lipoprotein concentrations varied in 5 men with advanced HIV-1 infection after 12 months of aerobic exercise training. Prior to exercise, the mean baseline cholesterol and high-density lipoprotein cholesterol (HDL-C) serum concentration were each lower, and mean baseline triglyceride concentration was higher compared to a healthy population norm. Consistent exercise training for 12 months failed to significantly (p > .05) alter cholesterol or HDL-C. Triglyceride concentration was significantly (p < .05) elevated above baseline (63 mg/dL) regardless of exercise compliance. The results suggest that long-term exercise training cannot correct lipid profile abnormality, particularly hypertriglyceridemia, common to individuals with advanced HIV-1 infection. 相似文献
2.
M. Laurin Council Jennifer M. Gardner Cynthia Helms Ying Liu Lynn A. Cornelius Anne M. Bowcock 《Experimental dermatology》2009,18(5):485-487
Abstract: The risks of developing malignant melanoma (MM) include ultraviolet irradiation and genetic factors. To examine the contribution of rare and common variation within known MM genes in sporadic US MM patients, coding regions of known MM susceptibility genes [cyclin-dependent kinase inhibitor 2A ( CDKN2A ), cyclin-dependent kinase 4, melanocortin 1 receptor ( MC1R ) and tyrosinase ( TYR )] were resequenced in 109–135 MM cases. The significance of variants was examined by comparing their frequencies in 390 cancer-free controls. Potential deleterious mutations in CDKN2A were found in two patients and two others had variants of unknown significance. Cases were more likely than controls to harbour the MC1R 'R' variants known or predicted to alter its function ( P = 0.002), particularly the R160W variant ( P = 0.0035). The associated TYR R402Q variant (rs1126809*A) was found in 29% of cases, similar to what has been described previously. One MM patient with a family history of MM, who had developed other skin cancers, was homozygous for a novel TYR variant (P406L) of unknown significance. Hence, rare variants in TYR may be important risk factors for skin cancer. 相似文献
3.
4.
D J Lynn 《American journal of psychotherapy》1989,43(1):108-117
A peculiarly effective intervention by the author's psychoanalyst is explored and discussed in terms of its implicitly expressive properties. It is placed in the context of the classical concept of opacity and more flexible Sullivanian ideas, as expanded and clarified by Havens. 相似文献
5.
6.
7.
8.
9.
J F Newton K M Straub R H Dewey C D Perchonock M E McCarthy J G Gleason R K Lynn 《Drug metabolism and disposition》1992,20(4):479-484
A primary route of inactivation of leukotrienes and their receptor antagonists (LTRA) is metabolism by omega oxidation. SK&F 102922 [5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid] is a LTRA that was designed to be resistant to omega oxidation. Therefore, these experiments were designed to characterize the metabolic fate of [14C]SK&F 102922. Following iv administration of SK&F 102922 (5 mg/kg), 80% of injected radioactivity was excreted in bile in 1 hr. At least five metabolites and parent (18% of administered dose) were present in bile. One metabolite (M1), which accounted for less than 10% of the excreted radioactivity, was monohydroxylated. Three metabolites (M2, M3A, and M3B), which together accounted for greater than 50% of excreted radioactivity, had mass spectra consistent with acyl glucuronides. All three metabolites were alkali labile, whereas only one metabolite (M2) was susceptible to beta-glucuronidase hydrolysis. These data indicate that M3a and M3b are nonglycosidic isomers of M2 that were formed by a nonenzymic reaction involving migration of the aglycone (SK&F 102922) from C-1 to C-2, C-3, or C-4 of glucuronic acid. The 1-O-acyl-beta-glucuronide of SK&F 102922 (M2) exhibits pH dependent rearrangement, with half-lives ranging from 1 to greater than 1000 hr. Therefore, acyl glucuronidation can account for much of the metabolic fate of SK&F 102922 and, potentially, other structurally related LTRAs or endogenous leukotrienes themselves. 相似文献
10.