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1.
目的评估十二指肠-空肠导管(Endoluminal Duodeno-Jejunal Tube,EDJT)在活体猪实验动物模型中减缓体重增加的可行性,及其在中短期生存中的安全性。方法本项研究共用8只45kg重的Yorkshire猪,其中3只置入180emEDJT,1只置入360cm EDJT,另4只猪作为对照组。切开十二指肠,将EDJT导管缝合固定在十二指肠近Vater壶腹起始处。结果评估全部猪的不适反应和体重,每日一次,共7周,未发现严重并发症发生。术后7周3组动物的平均体重变化百分率:对照组、180cm组和360cm组分别是22.5%,6%和-2.8%。EDJT组(180cm组、360cm组)体重增加明显减慢,与对照组相比,有统计学意义(P=0.05)。结论EDJT可以安全使用,无肠梗阻、肠套叠或胰腺炎等并发症发生。EDJT可明显减缓体重增加。 相似文献
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Hirofumi Tomiyama Jiko Yamada Yutaka Koji Minoru Yambe Kohki Motobe Kazuki Shiina Yoshio Yamamoto Akira Yamashina 《Hypertension research》2007,30(5):417-426
This observational study of Japanese men without metabolic syndrome (MetS) (age: 41+/-8 years) was conducted to clarify whether or not heart rate elevation precedes the development of full-blown MetS. MetS was defined based on two modifications of the criteria of the Japanese Expert Committee on the Diagnosis and Classification of Metabolic Syndrome. Premetabolic syndrome subjects were defined as those having one component of MetS with increased body mass index (BMI). Among the subjects without MetS (n=1,859 when the BMI criterion was >or=25 and n=2,020 when the BMI criterion was >or=27.5), the incidence of progression to full-blown MetS by the time of the second examination at the end of the 3-year study period was higher in the subjects with premetabolic syndrome than in those without it. The receiver-operator characteristic curve analysis and binary logistic regression analysis revealed that the odds ratio (OR) of a heart rate >or=69 beats/min at the first examination for progression to full-blown MetS by the time of the second examination was significant in subjects with premetabolic syndrome (BMI>or=25: OR=3.64 [1.22-10.88]; BMI>or=27.5: OR=3.67 [1.28-10.55]; p<0.05). Thus, heart rate elevation appears to precede the development of full-blown MetS in subjects with premetabolic syndrome. Heart rate seems to be a simple and useful marker for predicting the progression to full-blown MetS of middle-aged Japanese men with premetabolic syndrome. 相似文献
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Kazuki Hotta 《Ophthalmic surgery, lasers & imaging》2007,38(4):336-338
To determine postoperative refractive errors of secondary intraocular lens (IOL) implantation, this study was performed in 42 eyes of 42 patients following secondary IOL implantation fixed in the sulcus after simultaneous vitrectomy and phacoemulsification and aspiration. Controls were 138 eyes of 124 patients with cataract who underwent phacoemulsification and aspiration and IOL implantation. The spread between expected and actual refraction (actual - expected) was -0.81 +/- 0.86 diopters (average +/- standard deviation) in the study group and 0.01 +/- 0.91 diopters in the control group (statistically significant, P < .001, Student's t test). The actual refractive errors in the study subjects were shifted toward myopia compared with the controls. 相似文献
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Kazuki Tamura Tadayuki Oka Kazutaka Ohsawa Takehiko Koji Yoji Watanabe Shigeru Katamine Hiroshi Sato Hiroyoshi Ayabe 《The Journal of heart and lung transplantation》2003,22(4):452-459
BACKGROUND: Cytomegalovirus (CMV) diseases commonly occur in allograft recipients in the early post-transplant period. However, factors responsible for the high incidence of CMV diseases during this period are not yet fully defined. METHODS: Wistar-Furth (WF; RT-1(u)) rats were inoculated with 10(4) plaque-forming units (PFU) of rat CMV (RCMV) intraperitoneally, and then transplanted with allogeneic lungs from Dark Agouti (DA; RT-1avl) rats or stimulated with 10(7) mitomycin C-treated spleen cells from DA rats by daily sub-cutaneous injections for 2 weeks. No immunosuppressive agent was used. Naive WF rats and WF rats grafted with syngeneic lungs or cells were used as controls. The level of RCMV replication in rats was assessed by infectious virus titers in tissues. RESULTS: The virus titers in salivary glands of allogeneic and syngeneic lung graft recipients were significantly higher than in naive WF rats. The level of RCMV replication in rats stimulated with allogeneic spleen cells was significantly higher than in the syngeneic recipient rats: virus titers in the salivary gland of allogeneic and syngeneic recipients reached 4.61 +/- 0.33 and 4.00 +/- 0.37 log(10) PFU/g tissue, respectively, at 14 days post-infection (p = 0.015). The augmented viral replication in allogeneic recipients was confirmed by an increase in the number of RCMV antigen-positive macrophages present in tissue sections of the salivary gland. CONCLUSIONS: Acute lung allograft rejection and allogeneic spleen cell stimulation enhance CMV replication in the salivary gland of rats. Various responses to allogeneic antigens occurring in the process of acute allograft rejection could be risk factors for post-transplant CMV replication and infection. 相似文献
7.
Twenty-two patients with recurring attacks of tinnitus, hearing loss and dizziness were treated with transtympanally injected lidocaine. The tinnitus improved in 19, and the pure tone and speech audiometric thresholds decreased in 15 cases. The dizziness and latent spontaneous nystagmus disappeared in all subjects where these symptoms were manifest before treatment. 相似文献
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