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排序方式: 共有220条查询结果,搜索用时 15 毫秒
1.
N. SHINTANI T. NAKAJIMA M. SUGIURA K. MURAKAMI N. NAKAMURA Y. KAGITANI & T. MAYUMI 《Scandinavian journal of immunology》1997,46(6):581-586
The authors have previously reported that homologous immunoglobulin (Ig)G reduces the occurrence of dextran sulfate sodium (DSS)-induced colitis, mainly by suppressing recruitment of immunocompetent cells into colitis lesions. However, the mechanisms of cell recruitment and of its suppression by IgG remain unclear. In addressing these questions, this study focused on the activation of T cells in the presence of macrophages. The authors found that [3 H]-thymidine uptake of T cells from DSS-induced colitis mice, but not from normal mice, was significantly enhanced when cultured with DSS-pulsed macrophages. From the profile of cytokine production, it was suggested that T helper 1 (Th1)-type cells become predominant during stimulation. Addition of homologous IgG significantly suppressed T cell proliferation in a dose-dependent manner, while no suppressive effect was observed with heterologous IgG. Mouse IgG F(ab')2 , but not Fc, fragments partially mimicked the suppressive effect of whole IgG. These findings provide evidence that Th1-type cells may play an important role in the development of DSS-induced colitis and that homologous IgG exerts its protective action at least in part through the F(ab')2 portion. 相似文献
2.
J. FURMANIAK S. DAVENPORT Y. NAKAJIMA U. KAISER H.W. MULLER-GARTNER F. W. BUCKMANN C. PEGG B. REES SMITH 《Clinical endocrinology》1988,28(6):589-600
Affinity labelling with a 125I-labelled photoactive derivative of TSH (HSAB-TSH) was used to analyse TSH receptor size in the following specimens of human thyroid tissue: (1) cold nodules; (2) autonomous nodules; (3) papillary carcinoma; (4) medullary carcinoma; (5) metastasis of papillary carcinoma to lymph node; (6) anaplastic carcinoma, and (7) Graves' thyroid. In addition, a sample of histologically normal thyroid tissue surrounding specimens 1-4 was analysed in each case. Thyroid microsomes were also prepared from the tissue samples, solubilized using 1% deoxycholate and labelled with 125I. The preparations were immunoprecipitated using microsomal autoantibodies and protein A and analysed by SDS-PAGE and autoradiography. These studies indicated that no differences in the characteristics of the TSH receptor or of microsomal antigen were observed in the tissue samples 1-3 and 7. Neither protein was detected in tissue specimens 4-6. 相似文献
3.
Changes in Cell Characteristics Due to Culture Conditions in Cell Lines From Human Small Cell Lung Cancer 总被引:8,自引:0,他引:8
TERASAKI TAKEO; SHISMOSATO YUKIO; NAKAJIMA TAKASHI; TSUMURAYA MASARU; MORINAGA SHOJIROH; HIROHASHI SETSUO; YAMAGUCHI KEN; KATO KANEFUSA; ICHINOSR HIROSHI; NAGATSU TOSHIHARU 《Japanese journal of clinical oncology》1986,16(3):203-212
Eight cultured cell lines were established from human smallcell lung cancers. Every cell line showed the morphologicaland biochemical characteristics of small cell cancer. Changesin cell characteristics were observed in many of these celllines when culture conditions were changed: "oat cell type"changed to "intermediate cell type" and vice versa when serum-freemedium was changed to serum-supplemented medium; a deficiencyof vitamin A in the medium caused a change to squamous cellsand vice versa; and a tumor promoter (teleocidin B) enhancedthe adherence of these cells to the surface of plastic culturedishes. These findings provide evidence that many small celllung cancer cell lines can change their morphology with changesin the environment of the cells. 相似文献
4.
5.
HISAKI MAKIMOTO M.D. Ph.D. IKUTARO NAKAJIMA M.D. KOJI MIYAMOTO M.D. YUKO YAMADA M.D. HIDEO OKAMURA M.D. TAKASHI NODA M.D. Ph.D. TAKESHI AIBA M.D. Ph.D. SHIRO KAMAKURA M.D. Ph.D. KENGO KUSANO M.D. Ph.D. WATARU SHIMIZU M.D. Ph.D. KAZUHIRO SATOMI M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2015,38(5):630-640
6.
Hiroyuki NAKAJIMA Manabu NEMOTO Tetsuya TORIO Ririko TAKEDA Hidetoshi OOIGAWA Ryuichiro ARAKI Hiroki KURITA 《Neurologia medico-chirurgica》2014,54(5):379-386
Blunt cerebrovascular injury (BCVI) is known to be a potentially fatal complication of cervical spine injury (CSI). Methods for screening the appropriate population remain to be elucidated, especially in Japan. This retrospective study was conducted to predict the risk factors relevant to BCVIs. Among 92 patients with CSI transferred to our institution from April 2007 to March 2012, 40 patients (35 men, 5 women) with neurological deficits and/or significant cervical spine fracture including fracture of transversarium, facet, body, lamina, and spinous process, underwent multi-detector computed tomography angiography (MDCTA) and magnetic resonance angiography (MRA), which identified 10 patients with BCVI [2 carotid artery injuries (BCAIs) and 9 vertebral artery injuries (BVAIs); 1 patient suffered both]. Univariate analyses exploring associations between individual risk factors and BCVI and BVAI were performed using Fisher''s exact test and Chi-square test for dichotomous variables and the unpaired t-test for continuous variables. Multiple logistic regression analyses for BCVI and BVAI were carried out using stepwise methods. On univariate and multivariate analysis, hyperextension injury was significantly associated with BVAI (p = 0.01 and p = 0.02), and subluxation (dislocation of vertebral body > 5 mm) was a significant predictor of BCVI (p = 0.04 and p = 0.03) and BVAI (p = 0.01 and p = 0.01). Prompt evaluation for BCVIs is recommended in CSI patients with hyperextension injury and dislocation of the vertebral body. 相似文献
7.
Signet-ring cell carcinoma of the prostate effectively treated with maximal androgen blockade 总被引:3,自引:0,他引:3
KEIGO AKAGASHI HITOSHI TANDA SHUJI KATO SHIGEKI OHNISHI HISAO NAKAJIMA AKIHITO NANBU TOSHIKAZU NITTA MIKIO KOROKU 《International journal of urology》2003,10(8):456-458
Primary signet-ring cell carcinoma (SRCC) of the prostate is very rare and has a poor prognosis, even when treated with aggressive therapy. We report herein a case of a 72-year-old man with prostatic SRCC. The patient had a tumor that extended directly to the rectum. Maximal androgen blockade was started and 20 months later, the patient was alive without evidence of recurrence. The present case of prostatic SRCC responded well to medical therapy, however, tumors can recur after a long period of time. Therefore, adjuvant therapy is recommended. 相似文献
8.
EMI SAITOH KENICHI SUGITA HIDEMITSU KUROSAWA MOTOYUKI KUROSAKI MITSUOKI EGUCHI TOSHIHARU FURUKAWA CHIKAKO NAKAJIMA YASUAKI KOBAYASHI 《Pediatrics international》1995,37(6):710-712
We report on a 3 year old girl with acute promyelocytic leukemia (APL) with cerebral infarction due to disseminated intravascular coagulation (DIC) at initial presentation. She was hospitalized because of unconsciousness and petechiae on the chest wall and extremities. Cerebral ischemia and infarction were found on computed tomography scan and magnetic resonance imaging. Peripheral bood content was hemoglobin 7.3 g/dL, white blood cells 1.0 × 103cells/μL (31% blasts) and platelet count was 12 × 103cells/μL. Fragmented erythrocytes were frequently observed on May-Giemsa stained blood smears. Bone marrow aspirates showed normal cellularity, with 60.4% blasts, containing faggot cells. The blasts were positive for peroxidase. Therapy was begun; however, the patient died 1 week after admission. 相似文献
9.
Y. SUGITA T. NAGATANI Z. IKEZAWA K. NOMURA Y. WATANABE J. UITTO H. NAKAJIMA 《The British journal of dermatology》1992,126(5):468-473
Bullous pemphigoid (BP) is characterized by the production of autoantibodies against BP antigens. gamma-interferon (gamma-IFN), a T-cell lymphokine, is known to enhance the expression of several cell-surface proteins. In this study, keratinocytes were cultured in the presence of gamma-IFN, the expression of BP antigen protein was examined by flow cytometry and BP antigen messenger RNA (mRNA) (encoding 230-kDa protein) was quantified by slot-blot hybridization. The results indicated that BP antigen gene expression by keratinocytes was upregulated by gamma-IFN. This enhancement of gene expression was detected at both the protein and mRNA level, suggesting pretranslational regulation. These results imply the involvement of not only humoral immunity but also cell-mediated immunity in the development of BP. 相似文献
10.
H. MIYAMOTO T. NAGATANI S. MOHRI H. NAKAJIMA 《Clinical and experimental dermatology》1988,13(6):411-415
Intravascular papillary endothelial hyperplasia (IPEH) was first described by Masson.1 It is characterized by the development of endothelial-lined papillary projections in a vascular lumen. In Japan the disease was first reported by Tanimura et al.2 in 1976, and since then over 30 cases have been described. In this reort we describe a case of IPEH together with the review of these Japanese cases. 相似文献