全文获取类型
收费全文 | 224篇 |
免费 | 13篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 9篇 |
妇产科学 | 9篇 |
基础医学 | 22篇 |
口腔科学 | 3篇 |
临床医学 | 9篇 |
内科学 | 43篇 |
皮肤病学 | 2篇 |
神经病学 | 40篇 |
特种医学 | 18篇 |
外科学 | 29篇 |
综合类 | 10篇 |
预防医学 | 9篇 |
眼科学 | 2篇 |
药学 | 15篇 |
肿瘤学 | 18篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 6篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 6篇 |
2017年 | 3篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 7篇 |
2013年 | 5篇 |
2012年 | 8篇 |
2011年 | 7篇 |
2010年 | 7篇 |
2009年 | 2篇 |
2008年 | 1篇 |
2007年 | 12篇 |
2006年 | 4篇 |
2005年 | 13篇 |
2004年 | 12篇 |
2003年 | 8篇 |
2002年 | 10篇 |
2001年 | 8篇 |
2000年 | 18篇 |
1999年 | 12篇 |
1998年 | 4篇 |
1997年 | 11篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 8篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有238条查询结果,搜索用时 15 毫秒
1.
A general overview of the literature concerning the development of diabetic neuropathic arthropathy is discussed. A case report is presented dealing with spontaneous fractures of the lesser metatarsal in a patient with an amputated hallux and peripheral neuropathy secondary to diabetes mellitus. 相似文献
2.
3.
K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung. 总被引:2,自引:0,他引:2
Giuseppe Pelosi Aldo Scarpa Michela Manzotti Giulia Veronesi Lorenzo Spaggiari Filippo Fraggetta Oscar Nappi Elvira Benini Felice Pasini Davide Antonello Antonio Iannucci Patrick Maisonneuve Giuseppe Viale 《Modern pathology》2004,17(5):538-546
We investigated 27 pleomorphic carcinomas of the lung for exon 1 K-ras gene mutations using polymerase chain reaction-single-strand conformation polymophism analysis and direct sequencing. All pleomorphic carcinomas were biphasic, that is, composed of an adeno-, squamous- or large-cell-carcinomatous component associated with a spindle- and/or giant-cell component. Of 27 cases, six (22%) showed K-ras codon 12 mutations, which is a figure higher than that previously reported on in pure sarcoma-like pleomorphic carcinomas. Five tumors displayed the same mutation in both the epithelial and the sarcomatoid components, whereas in one tumor the mutation was restricted to the epithelial component. All mutations occurred in smokers, and were transversions, including GGT (glycine) to TGT (cysteine) change in two cases, to GCT (alanine) in two and to GTT (valine) in two. No significant relationships were found between the occurrence and type of mutations and patients' survival or any other clinicopathological variable, suggesting that K-ras mutations are early events in the development of these tumors. Our results indicate that most, though not all, biphasic pleomorphic carcinomas of the lung are monoclonal in origin, and that cigarette smoking may have a causative role in the development of K-ras alterations in these tumors, as all mutations are transversions. 相似文献
4.
5.
Immunohistochemical analysis of thymoma. Evidence for medullary origin of epithelial cells 总被引:7,自引:0,他引:7
M Chilosi A M Iannucci G Pizzolo F Menestrina L Fiore-Donati G Janossy 《The American journal of surgical pathology》1984,8(4):309-318
The histologic organization of lymphoid and nonlymphoid (epithelial and interdigitating) cells in a thymoma has been compared to that of the normal thymus. Enzyme and immunohistochemical methods were applied, using both conventional antisera (to cytokeratin) and monoclonal antibodies (to epithelial cells, HLA-DR and lymphoid subsets). Throughout the tumor, the epithelial cells shared phenotypical similarities with the epithelial cells of thymic medulla (RFD-4 positive, cytokeratin strongly positive, and HLA-DR essentially negative). On the other hand, the lymphoid cells were heterogeneous in phenotype and distribution, and "mimicked" the distribution seen in the normal infant thymus. Immature thymocytes of cortical type (TdT+, OKT6+, OKT3-) were predominant in the areas with moderate lymphocytic infiltration (ML). Mature T-lymphocytes (TdT-, OKT6-, OKT3+) were found mainly in areas with scanty lymphocytes (SL) together with an additional population of HLA-DR positive interdigitating and HLA-DR+, OKT6+ Langerhans'-type cells. These findings indicate that in thymoma tissue, the lymphoid elements of cortical type are apparently surrounded by an inappropriate (medullary) epithelium. 相似文献
6.
Maria Rosaria Melis Salvatora Succu Umberto Iannucci A. Argiolas 《Naunyn-Schmiedeberg's archives of pharmacology》1997,355(5):595-600
The possible involvement of nitric oxide in the prevention by morphine of apomorphine- and oxytocin-induced penile erection
and yawning was investigated by measuring the concentration of NO2- and NO3- in the dialysate obtained with a vertical microdialysis probe implanted in the paraventricular nucleus of the hypothalamus
of male rats. Either apomorphine (80 μg/kgs.c.) or oxytocin (30 ng i.c.v.) increased significantly basal NO2- and NO3- concentration in the paraventricular dialysate, penile erection and yawning. Morphine (1, 5 and 10mg/kg i.p.) prevented
dose-dependently either apomorphine or oxytocin responses when given 15min before apomorphine or oxytocin. Prevention by morphine
of apomorphine and oxytocin responses was abolished by naloxone (3mg/kg i.p.) given 15min before morphine. Morphine prevented
apomorphine and oxytocin responses also when given in the lateral ventricles or directly in the paraventricular nucleus. In
contrast, the selective agonist of the kappa opioid receptor subtype U-69,593 was found to be ineffective. The present results
confirm previous findings showing that morphine acts through μ receptors in the paraventricular nucleus to prevent apomorphine
and oxytocin-induced penile erection and yawning and suggest that this morphine effect is mediated by a decreased activity
of nitric oxide in the paraventricular nucleus of the hypothalamus.
Received: 30 September 1996 / Accepted: 24 January 1997 相似文献
7.
Bozzali M Rocca MA Iannucci G Pereira C Comi G Filippi M 《AJNR. American journal of neuroradiology》1999,20(10):1803-1808
BACKGROUND AND PURPOSE: Previous studies have failed to show significant correlations between the number and extent of T2 spinal cord lesions and the clinical status of multiple sclerosis (MS) patients. We evaluated 1) whether it is feasible to create magnetization transfer-ratio (MTR) histograms of the cervical cord in patients with MS by using two different acquisition schemes, and 2) whether cervical cord MTR histogram metrics were different from those of healthy control subjects and between MS patients with and without locomotor disability. METHODS: We obtained two sets of gradient-echo sequences with and without a saturation pulse from 90 MS patients and 20 sex- and age-matched healthy control subjects. One set consisted of 20 axial, contiguous slices with a thickness equal to 5 mm. The other set consisted of 17 sagittal slices with a thickness equal to 3 mm and an interslice gap equal to 0.3 mm. After image coregistration and removal of tissues around the cervical cord, MTR histograms were created. The average MTR, the peak height, and the peak position of the histograms were measured. All of these measurements were from the whole of the cervical cord, thus including both MS lesions and normal-appearing tissue. RESULTS: When comparing the MTR histograms obtained using axial, contiguous, 5-mm-thick slices, MS patients had significantly lower average cervical cord MTR and peak height than did control subjects. When comparing the MTR histograms obtained using sagittal, 3-mm-thick slices, MS patients also had significantly lower average cervical cord MTR and peak location than did control subjects. Patients with locomotor disability had significantly lower average cord MTR and peak location than those without. CONCLUSION: This study shows that it is feasible to obtain MTR histograms of the cervical cord from MS patients by using different acquisition schemes. Our results also suggest that the assessment of MS cervical cord damage, achieved using MTR histograms, may lead to a better understanding of the clinical manifestations of the disease. 相似文献
8.
Background
Purified water for pharmaceutical purposes must be free of microbial contamination and pyrogens. Even with the additional sanitary and disinfecting treatments applied to the system (sequential operational stages), Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas alcaligenes, Pseudomonas picketti, Flavobacterium aureum, Acinetobacter lowffi and Pseudomonas diminuta were isolated and identified from a thirteen-stage purification system. To evaluate the efficacy of the chemical agents used in the disinfecting process along with those used to adjust chemical characteristics of the system, over the identified bacteria, the kinetic parameter of killing time (D-value) necessary to inactivate 90% of the initial bioburden (decimal reduction time) was experimentally determined. 相似文献9.
Piccirillo G Vetta F Ronzoni S Rizzo V Fimognari FL Bucca C Santagada E Monteforte G Durante M Palleschi L Viola E Valdivia JL Tarantini S Cacciafesta M Villani M Iannucci G Marigliano V 《Archives of gerontology and geriatrics》1998,26(1):85-96
In order to assess high-pressure barocepture sensitivity and parasympathetic function in elderly patients with silent myocardial ischemia, we selected 45 inpatients in our geriatric unit for a prospective cohort study of patients with coronary heart disease. All patients were over 65 years of age (37 men and 8 women) and had coronary heart disease, documented by an angiographic study and electrocardiographic evidence of myocardial ischemia during exercise stress testing, performed according to the Bruce protocol. The subjects were divided in three subgroups: group 1 (22 patients) with electrocardiographic and echocardiographic history of myocardial infarction but no angina chest pain during exercise testing; group 2 (13 patients) with no exercise induced chest pain; and group 3 (10 patients) with exercise-induced chest pain. Baroceptor sensitivity was assessed in all subjects, by evaluating heart rate changes expressed in RR interval on the basis of changes in the mean arterial pressure during intravenous infusion of stepwise doses (50-100 and 150 mug) of phenylephrine hydrochloride. Heart rate changes were also evaluated during overshoot of the Valsalva maneuver (Valsalva max.), providing an index of parasympathetic activity. Our results showed that group two patients (only silent ischemia) had significantly (P>0.001) greater baroceptor sensitivity than the other two groups (group 2; 15.2+/-1.9 ms/mmHg; group 1: 10.0+/-1.7 ms/mmHg; and group 3: 9.8+/-1.7 ms/mmHg). Group two also showed a significant positive correlation (r=0.58; P<0.05) between baroceptor sensitivity and end-diastolic pressure and a significant inverse correlation (r=-0.672; P<0.05) between baroceptor sensitivity and the ejection fraction. Group 2 patients had a significantly longer RR interval than group 1 (P<0.05) and group 3 (P<0.05); a significant positive correlation (r=0.620; P<0.05) between Valsalva max. and end-diastolic pressure; and a significant inverse correlation (r=0.694; P<0.05) between Valsalva max. and the ejection fraction. Valsalva max. and baroceptor sensitivity correlated significantly in all three groups (group 1, r=0.707; P<0.001; group 2, r=0.94; P<0.001; and group 3; r=0.833; P<0.05). In conclusion our data suggest that elderly patients with silent ischemia appear to have an increased capacity for evoking parasympathetic reflexes that could inhibit pain perception. 相似文献
10.
Liver Involvement in Obese Children (Ultrasonography and Liver Enzyme Levels at Diagnosis and During Follow-up in an Italian Population) 总被引:26,自引:0,他引:26
Maria Carmela Saviano Francesco Brunetti Armido Rubino Adriana Franzese Pietro Vajro Alessandro Argenziano Alessandro Puzziello Maria Pina Iannucci 《Digestive diseases and sciences》1997,42(7):1428-1432
Our aim was to evaluate incidence and riskfactors of liver involvement in obese Italian childrenas assessed by both ultrasonographic and biochemicalparameters. In seventy-five consecutive obese children (age 9.5 ± 2.9 years, males/females41/34), serum levels of enzymes and ultrasonography ofthe liver were evaluated. Tests were repeated one,three, and six months after starting a moderatehypocaloric diet and an exercise program. Three obese childrenwho were found to have chronic viral hepatitis wereexcluded from the study. Thirty-eight of 72 (53%) obesechildren had an ultrasonographic image of bright liver consistent with liver steatosis. Thelatter was severe in nine children, moderate in 16, andmild in 13. Eighteen obese children (25%) had elevatedtransaminase levels. Bright liver andhypertransaminasemia were not due to any of the most common causesof liver disease. Both were rapidly responsive to lossof weight, confirming that liver involvement wassecondary to obesity and that steatosis orsteatohepatitis rather than fibrosis were involved. Obesityduration not more than three years (odds ratio = 4.77),a higher degree of obesity (odds ratio = 2.09), andhypertransaminasemia (odds ratio = 2.15) appeared asimportant predictive factors of liver involvement atultrasonography. Incidence of liver involvement assessedby means of ultrasonography is significantly higher thanthat revealed by measurement of serum liver enzymes. A short duration of obesity emerged as apotentially new risk factor of liver involvement in thepediatric obese population and needs to be confirmed infuture studies. 相似文献