全文获取类型
收费全文 | 975篇 |
免费 | 50篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 87篇 |
妇产科学 | 7篇 |
基础医学 | 71篇 |
口腔科学 | 11篇 |
临床医学 | 76篇 |
内科学 | 309篇 |
皮肤病学 | 5篇 |
神经病学 | 60篇 |
特种医学 | 166篇 |
外科学 | 89篇 |
综合类 | 15篇 |
一般理论 | 3篇 |
预防医学 | 49篇 |
眼科学 | 9篇 |
药学 | 44篇 |
中国医学 | 1篇 |
肿瘤学 | 28篇 |
出版年
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 6篇 |
2018年 | 18篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 14篇 |
2014年 | 12篇 |
2013年 | 22篇 |
2012年 | 34篇 |
2011年 | 39篇 |
2010年 | 27篇 |
2009年 | 22篇 |
2008年 | 30篇 |
2007年 | 34篇 |
2006年 | 40篇 |
2005年 | 27篇 |
2004年 | 22篇 |
2003年 | 27篇 |
2002年 | 36篇 |
2001年 | 40篇 |
2000年 | 25篇 |
1999年 | 35篇 |
1998年 | 42篇 |
1997年 | 29篇 |
1996年 | 31篇 |
1995年 | 28篇 |
1994年 | 22篇 |
1993年 | 20篇 |
1992年 | 13篇 |
1991年 | 13篇 |
1990年 | 21篇 |
1989年 | 25篇 |
1988年 | 27篇 |
1987年 | 20篇 |
1986年 | 23篇 |
1985年 | 25篇 |
1984年 | 14篇 |
1983年 | 16篇 |
1982年 | 24篇 |
1981年 | 10篇 |
1980年 | 16篇 |
1979年 | 6篇 |
1978年 | 11篇 |
1977年 | 14篇 |
1976年 | 13篇 |
1975年 | 8篇 |
1972年 | 3篇 |
1970年 | 3篇 |
1969年 | 3篇 |
排序方式: 共有1033条查询结果,搜索用时 15 毫秒
1.
B Gerdts AFPM Vloemans RW Kreis 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):781-788
BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe and potentially fatal drug reaction characterized by an extensive skin rash with blisters and exfoliation, frequently accompanied by mucositis. The wounds caused by TEN are similar to second-degree burns and severe cases may involve large areas of skin loss. OBJECTIVES: Analysis of our results in patients with TEN and evaluation of the variety of therapeutic interventions that has been studied and suggested in TEN. PATIENTS/METHODS: Retrospective analysis of 19 consecutive patients with TEN treated in our burns centre between 1989 and 2004. RESULTS: Immediate withdrawal of any potentially fatal drug, maximum supportive care, and a restricted and tailored antibiotic, medical and surgical treatment regimen confined mortality to 21%, whereas prognosis scores like APACHE II and SCORTEN predicted mortality of 22 and 30%, respectively. A positive contribution of selective digestive decontamination is suggested but has yet to be established. CONCLUSIONS: Because of a potentially fatal outcome, fast referral of a patient suspected of TEN to a specialized centre (mostly a burns unit or specialized dermatology centre) for expert wound management and tailored comprehensive care is strongly advised and contributes to survival. 相似文献
2.
3.
Characterization of a benzyladenine binding-site peptide isolated from a wheat cytokinin-binding protein: sequence analysis and identification of a single affinity-labeled histidine residue by mass spectrometry 总被引:3,自引:1,他引:2
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A C Brinegar G Cooper A Stevens C R Hauer J Shabanowitz D F Hunt J E Fox 《Proceedings of the National Academy of Sciences of the United States of America》1988,85(16):5927-5931
A wheat embryo cytokinin-binding protein was covalently modified with the radiolabeled photoaffinity ligand 2-azido-N6-[14C]benzyladenine. A single labeled peptide was obtained after proteolytic digestion and isolation by reversed-phase and anion-exchange HPLC. Sequencing by classical Edman degradation identified 11 of the 12 residues but failed to identify the labeled amino acid. Analysis by laser photodissociation Fourier-transform mass spectrometry of 10 pmol of the peptide independently confirmed the Edman data and also demonstrated that the histidine residue nearest the C terminus (underlined) was modified by the reagent in the sequence Ala-Phe-Leu-Gln-Pro-Ser-His-His-Asp-Ala-Asp-Glu. 相似文献
4.
M. Uhl K. H. Allmann C. Ihling M. P. Hauer W. Conca M. Langer 《Skeletal radiology》1998,27(12):677-682
Purpose. To assess the accuracy of different MR sequences for the detection of articular cartilage abnormalities in rheumatoid arthritis.
Design and patients. Ten metacarpophalangeal joints and 10 metatarsophalangeal joints (specimens from arthritis patients undergoing ablative joint
surgery) were examined with a fat-suppressed (FS) 3D FLASH, a FS 3D FISP, a FS 2D fast spin-echo T2-weighted, and a 2D FS
spin-echo T1-weighted sequence. Each cartilage lesion and each cortical lesion was graded from 0 to 4 (modified Outerbridge
staging system). Subsequently, the results of each sequence were compared with the macroscopic findings and statistically
tested against each other. Results. The study shows that 3D gradient-echo sequences with fat suppression were best for imaging and grading of cartilage lesions
in arthritis of the small joints of the hands and feet. Using 3D techniques, all grade 2, grade 3, and grade 4 lesions of
cartilage or cortical bone were detected. Conclusion. FS 3D gradient-echo techniques were best for the detection and grading of hyaline cartilage and subchondral bone lesions
in rheumatoid arthritis. MRI has a great potential as an objective method of evaluating cartilage damage and bone erosions
in rheumatoid arthritis. 相似文献
5.
6.
Beatrijs J. A. Hauer I. Wessel H. Merckelbach 《Clinical psychology & psychotherapy》2006,13(4):264-268
Previous studies have shown a positive relationship between intrusions, effortful avoidance and overgeneral memory in people suffering from (mild) depression or PTSD. The purpose of the present study was to investigate these relationships in a non‐clinical sample. As part of a mass testing session, a written version of the Autobiographical Memory Test was administered to 175 first‐year psychology students. Furthermore, intrusion and avoidance symptoms were measured with the Impact of Event Scale (Horowitz, Wilner, & Alvarez, 1979), and depressive symptoms with the Beck Depression Inventory (Beck, Ward, Mendelson, Mock, & Erbaugh, 1961). The data demonstrated a significant correlation between avoidance symptoms and categoric memory to negative cue words. This relationship remained significant after controlling for depressive symptoms. These results concur with other findings that overgeneral memory tends to be related to symptoms of effortful avoidance. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
7.
8.
9.
10.