收费全文 | 489篇 |
免费 | 11篇 |
国内免费 | 2篇 |
耳鼻咽喉 | 25篇 |
儿科学 | 44篇 |
妇产科学 | 27篇 |
基础医学 | 31篇 |
口腔科学 | 9篇 |
临床医学 | 39篇 |
内科学 | 71篇 |
皮肤病学 | 5篇 |
神经病学 | 33篇 |
特种医学 | 27篇 |
外科学 | 83篇 |
综合类 | 9篇 |
预防医学 | 9篇 |
眼科学 | 53篇 |
药学 | 14篇 |
肿瘤学 | 23篇 |
2022年 | 6篇 |
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 14篇 |
2015年 | 18篇 |
2014年 | 23篇 |
2013年 | 27篇 |
2012年 | 45篇 |
2011年 | 38篇 |
2010年 | 21篇 |
2009年 | 9篇 |
2008年 | 17篇 |
2007年 | 37篇 |
2006年 | 28篇 |
2005年 | 45篇 |
2004年 | 47篇 |
2003年 | 47篇 |
2002年 | 28篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1986年 | 1篇 |
Background
Decreased posterior cerebral circulation has been observed in patients with vertebrobasilar insufficiency (VBI). Reduced cerebral perfusion may have an impact on mental performance as measured by the Benton Facial Recognition Test (BFRT). We evaluated the usefulness of BFRT in identifying cognitive decline in patients with VBI by correlating test performance with total blood flow in the vertebrobasilar system and other variables such as educational level and gender.Materials and methods
Thirty-three participants without dementia (mini-mental state examination; MMSE >27) and cranial magnetic resonance imaging abnormality, but with atherosclerotic risk factors were involved in the study. Nineteen subjects had a total vertebrobasilar flow volume less than 200 ml/min (Group I), and 14 subjects had a flow volume more than 200 ml/min (Group II).Results
The groups were similar in regard to gender, age, and educational level. BFRT results were 19.53 ± 3.12 and 22.36 ± 2.73 for Groups I and II, respectively (p = 0.01). The educational level was the main factor affecting the BFRT score in Group I (p = 0.04).Discussion
BFRT is clearly impaired in VBI as measured by Doppler ultrasound examination. We concluded that the test appears to adequately distinguish cognitive levels between VBI and other patients. Additionally, our results suggest that education is associated with BFRT results, and for normative purposes, gender consideration is unnecessary. Further studies are needed to investigate the association between VBI and memory dysfunction in early dementia. 相似文献Objectives
Prolidase is a member of the matrix metalloproteinase family. It plays a major role in collagen turnover, matrix remodeling and cell growth. Nitric oxide (NO) regulates many processes such as collagen synthesis and matrix remodeling. Thus, NO may augment angiogenesis, tumor invasion, and metastasis. The aim of this study was to investigate total antioxidant status (TAS), malondialdehyde (MDA) and NO levels in patients with bladder cancer and to determine their relationship with prolidase activity.Design and methods
Thirty-five patients with bladder cancer and 32 controls were enrolled. Serum TAS, MDA, prolidase activity and NO levels were determined.Results
Serum prolidase activity, NO levels and MDA levels were significantly higher in bladder cancer than controls (all, P < 0.05), while TAS levels were significantly lower (P < 0.05).Conclusions
Our results show that increased prolidase seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in bladder cancer.Iris claw intraocular lenses (IOLs) were successfully used for the management of aphakia in patients that lack capsular support. The aim of this study was to compare the clinical outcome of prepupillary and retropupillary implantation of these IOLs.
MethodsThe files of the 26 patients that had an iris claw IOL implantation between 2010 and 2020 were retrospectively reviewed. Detailed ophthalmological examination findings including corrected distance visual acuity (CDVA), intraocular pressure, endothelial cell counts, slit lamp and dilated fundus examination findings were specifically tabulated. Intraoperative and postoperative complications were also specifically recorded.
ResultsThere were 18 patients in the prepupillary implantation group and eight patients in the retropupillary implantation group. Age and gender distribution were similar between the groups. CDVA significantly increased in prepupillary and retropupillary implantation groups (p?=?0.001 and p?=?0.012, respectively). Median endothelial cell loss was 6.7% in prepupillary group and 7.2% in retropupillary group. The only intraoperative complication was iridodialysis (n?=?1). Postoperative complications included retinal detachment (n?=?1), cystoid macular edema (n?=?2) and IOL tilt (n?=?1). All of these complications occurred in the prepupillary implantation group.
ConclusionPrepupillary and retropupillary implantation of iris claw IOLs resulted with similar visual gain and endothelial loss rates in a follow-up time of 6 months. There was an insignificant trend toward a reduced complication rate following retropupillary implantation.
相似文献